Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei

Kieft, Rudo; Stephens, Natalie; Capewell, Paul; MacLeod, Annette; Hajduk, Stephen L.

doi:10.1016/j.molbiopara.2011.12.004

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…Similar results were found in T. b. brucei , genetically very close to T. evansi , after 9 months of in vivo selection with NHS [153]. It was suggested that the reduction of ApoL-1 uptake might be associated with the low level of haptoglobin-hemoglobin receptor expression [154]. Whether T. evansi could develop any of the above strategies or others to resist ApoL-1 lysis remains uncertain.…”

Section: Zoonotic Aspectsmentioning

confidence: 53%

Trypanosoma evansiand Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects

Desquesnes

Dargantes

Lai

et al. 2013

BioMed Research International

231

261

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This paper reviews the transmission modes of Trypanosoma evansi. Its worldwide distribution is attributed to mechanical transmission. While the role of tabanids is clear, we raise questions on the relative role of Haematobia sp. and the possible role of Stomoxys sp. in delayed transmission. A review of the available trypanocidal drugs and their efficacy in various host species is useful for understanding how they interact in disease epidemiology, which is complex. Although there are similarities with other mechanically transmitted trypanosomes, T. evansi has a more complex epidemiology due to the diversity of its hosts and vectors. The impact of clinical and subclinical disease is difficult to establish. A model was developed for buffaloes in the Philippines, which could be transferred to other places and livestock systems. Since Trypanosoma evansi was reported in humans, further research is required to investigate its zoonotic potential. Surra remains a potentially emerging disease that is a threat to Australia, Spain, and France. A number of questions about the disease have yet to be resolved. This brief review of the basic knowledge of T. evansi suggests that there is renewed interest in the parasite, which is spreading and has a major economic impact.

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Section: Zoonotic Aspectsmentioning

confidence: 53%

Trypanosoma evansiand Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects

Desquesnes

Dargantes

Lai

et al. 2013

BioMed Research International

231

261

View full text Add to dashboard Cite

show abstract

“…Tbg has evolved independent mechanism(s) from Tbr for evading trypanolysis, one of which involves the haptoglobin-receptor, HbHpr [67,68]. Based on a survey of a small number of strains from the three subspecies for genetic variation in HbHpr , five fixed, non-synonymous amino acid substitutions were identified and hypothesized to be involved in evading the immunological response [69]. A genetic screen of HbHpr on a geographically more comprehensive sampling than the previous study, however, confirmed only one of these substitutions as fixed [70].…”

Section: Genetics Of Tsetse Populations Transmitting Tbr and Tbg Paramentioning

confidence: 99%

Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda

Aksoy

Caccone

Galvani

et al. 2013

Trends in Parasitology

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Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south. The recent spread of rhodesiense into central Uganda has raised concerns given the different control strategies the two diseases require. We present knowledge on the population genetics of the major vector species Glossina fuscipes fuscipes in Uganda with a focus on population structure, measures of gene flow between populations, and the occurrence of polyandry. The microbiome composition and diversity is discussed, focusing on their potential role on trypanosome infection outcomes. We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda and potential future genetic applications.

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Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

Kennedy

2013

The Lancet Neurology

393

382

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Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei

Cited by 4 publications

References 24 publications

Trypanosoma evansiand Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects

Trypanosoma evansiand Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects

Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

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