Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo

Abstract

Fibroblasts may be persistently activated by UV exposure to release melanogenic growth factors; this inducible cytokine network acts both directly and indirectly through keratinocytes and may contribute to the hyperpigmentation of SL.

Hyperpigmentation in human solar lentigo is promoted by heparanase-induced loss of heparan sulfate chains at the dermal–epidermal junction

“…including endothelin-1, endothelin receptor B, stem cell factor (SCF), SCF receptor (c-KIT), melanocyte-stimulating hormone (MSH), MSH receptor [8], keratinocyte growth factor (KGF), KGF receptor [9,10] and hepatocyte growth factor (HGF) [11], are increased in solar lentigine lesions. Interestingly, two recent geneprofiling studies identified several inflammatory molecules that are up-regulated in solar lentigine lesions [8,12].…”

“…KGF, SCF and HGF are produced by dermal fibroblasts and act on epidermal keratinocytes and melanocytes [11,[21][22][23]. VEGF-A is synthesized in the epidermis and promotes vascular endothelial cell growth in the dermis [24].…”

Use of Redness Assessment in Melasma Lesions in Skin Whitening Evaluation

“…In this study, we considered solar lentigo. The pathogenesis of solar lentigo is commonly known to relate to UV light exposure [15,16]. According to the previous studies, pathogenesis of melasma is more varied and complex than pathogenesis of solar lentigo.…”

Vitiligo: characterization of melanocytes in repigmented skin after punch grafting

“…In fact, the pro-melanogenic factors HGF, bFGF together with keratinocyte growth factor (KGF) are all induced in the course of the healing process. [30][31][32] Matrix metalloproteinases (MMPs) such as MMP-2 are known to be up-modulated during wound healing and these proteins are important contributors in melanoblast migration. 33 In the course of the healing process, it has been also recently demonstrated that follicular melanocyte stem cells migrate to the epidermis through the involvement of the melanocortin 1 receptor (Mc1R) signalling and differentiate into functional melanocytes.…”