Role of gene polymorphism of the renin-angiotensin system components in development of cardiovascular diseases, excess body weight and obesity in inhabitants of the Adyghea Republic

Muzhenya, Dmitriy Vitalevich; Tuguz, A. R.; Lysenkov, S. P.; Takushinov, Rustem A.; Ozheva, Raziet Sh.

doi:10.21638/11701/spbu11.2018.402

“…Многие исследования показывают существенные различия в распределении полиморфизма гена ACE D/I между разными этническими группами и даже внутри одной этнической группы. В то же время необходимо также учитывать возможность генных взаимодействий и роль эпигенетической изменчиво-сти, в том числе в условиях влияния факторов среды обитания, в формировании наследственной предрасположенности [3,7,[21][22][23][24][25].…”

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ACE I/D genetic polymorphism as a risk factor of essential hypertension

Starkova¹,

Dolgikh²,

Kazakova³

et al. 2022

Health Risk Analysis

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Examining genetic mechanisms of essential hypertension as a cardiovascular risk factor will make it possible to provide monitoring of public health using a personified approach to early diagnostics of cardiovascular pathologies. This will raise effectiveness of preventive activities aimed at reducing population mortality. Our research goal was to examine features of ACE (the angiotensin-converting enzyme) I/D gene polymorphism (rs4646994) as a risk factor of essential hypertension. Our test group included 35 people with diagnosed essential hypertension; the reference group was made of 34 relatively healthy people. Lipid spectrum indicators were estimated with an automated or semi-automated analyzer or by calculation. Insulin and cytokines were determined by using the enzyme immunoassay. Genotyping was performed by using the polymerase chain reaction in real time mode. The research results revealed that the examined patients with essential hypertension had authentic differences from the reference group regarding BMI, lipid spectrum indicators with very low density lipoproteins and triglycerides contents being by 1.3 times higher; insulin contents, by 1.9 times higher; IL-6 contents, by 2.2 times higher; and VEGF, by 1.4 times higher. Genetic analysis revealed 1.3-time higher prevalence of the D-allele of the ACE I/D gene in the patients with essential hypertension (we showed that the dominant inheritance was adequate, P = 0.041). The carriage of this allele was associated with the analyzed disease (OR = 3.16; 95 % CI = 1.08–9.20). We showed an association between insertion-deletion polymorphisms of the ACE (the angiotensin-converting enzyme) I/D gene and developing essential hypertension in the examined test group (the relative risk was RR = 1.87; 95 % CI =1.07–3.61). This polymorphism can be considered a potential marker of sensitivity to developing essential hypertension.

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“…Many studies have established significant differences in distribution of ACE D/I gene polymorphism between various ethnic groups and even within the same ethnic group. At the same time, it is necessary to consider possible genetic interactions and a role played by epigenetic changeability, including that occurring under influence of environmental factors, in formation of hereditary predisposition [3,7,[21][22][23][24][25].…”

mentioning

confidence: 99%

ACE I/D genetic polymorphism as a risk factor of essential hypertension

Starkova¹,

Dolgikh²,

Kazakova³

et al. 2022

Health Risk Analysis

2

0

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Examining genetic mechanisms of essential hypertension as a cardiovascular risk factor will make it possible to provide monitoring of public health using a personified approach to early diagnostics of cardiovascular pathologies. This will raise effectiveness of preventive activities aimed at reducing population mortality. Our research goal was to examine features of ACE (the angiotensin-converting enzyme) I/D gene polymorphism (rs4646994) as a risk factor of essential hypertension. Our test group included 35 people with diagnosed essential hypertension; the reference group was made of 34 relatively healthy people. Lipid spectrum indicators were estimated with an automated or semi-automated analyzer or by calculation. Insulin and cytokines were determined by using the enzyme immunoassay. Genotyping was performed by using the polymerase chain reaction in real time mode. The research results revealed that the examined patients with essential hypertension had authentic differences from the reference group regarding BMI, lipid spectrum indicators with very low density lipoproteins and triglycerides contents being by 1.3 times higher; insulin contents, by 1.9 times higher; IL-6 contents, by 2.2 times higher; and VEGF, by 1.4 times higher. Genetic analysis revealed 1.3-time higher prevalence of the D-allele of the ACE I/D gene in the patients with essential hypertension (we showed that the dominant inheritance was adequate, P = 0.041). The carriage of this allele was associated with the analyzed disease (OR = 3.16; 95 % CI = 1.08–9.20). We showed an association between insertion-deletion polymorphisms of the ACE (the angiotensin-converting enzyme) I/D gene and developing essential hypertension in the examined test group (the relative risk was RR = 1.87; 95 % CI =1.07–3.61). This polymorphism can be considered a potential marker of sensitivity to developing essential hypertension.

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Association of gene polymorphisms of angiotensin metabolism with left ventricular diastolic dysfunction in hypertensive patients

Kalinkina

¹

,

Lareva

²

,

Chistyakova

³

et al. 2023

Tihookeanskij medicinskij žurnal

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Aim. To investigate the relationship of SNP ACE ((AluIns/DelI>D), rs 4646994), SNP of angiotensinogen 1 gene AGT :521 C>T ((Thr 174 Met), rs 4762), SNP of angiotensinogen 2 gene AGT:704 T>C ((Met 235 Thr), rs699), SNP of angiotensin-2 type 1 receptor gene AGTR1: A1166C; A>C (rs5186) with left ventricular diastolic dysfunction in hypertensive patients.Methods and materials. 74 patients (26 women and 48 men) with stage 1-2 hypertension were examined. The analysis of genetic polymorphisms was carried out by means of polymerase chain reaction method with the analysis of DNA RFLP (restriction fragment length polymorphism).Results. CC polymorphisms of genotype AGT:704 T>C (Met 235 Thr), (χ2 = 8.18; p = 0.017) were detected in the group of patients with left ventricular diastolic dysfunction, which nearly triples the probability of impaired myocardial relaxation (OR 2.85) and CC polymorphisms of genotype of angiotensinogen type 1 receptor gene (AGTR1: A1166C), (χ2 = 1.77; p = 0.041), which doubles the probability of left ventricular diastolic dysfunction (OR 2.39).Conclusion. CC genotype AGT:704 T>C (Met 235 Thr) and CC genotype of the angiotensinogen type 1 receptor gene (AGTR1: A1166C) are associated with the development of left ventricular diastolic dysfunction in patients with hypertension.

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Role of gene polymorphism of the renin-angiotensin system components in development of cardiovascular diseases, excess body weight and obesity in inhabitants of the Adyghea Republic

Cited by 4 publications

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ACE I/D genetic polymorphism as a risk factor of essential hypertension

ACE I/D genetic polymorphism as a risk factor of essential hypertension

ACE I/D genetic polymorphism as a risk factor of essential hypertension

Association of gene polymorphisms of angiotensin metabolism with left ventricular diastolic dysfunction in hypertensive patients

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