Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

Borrelli, Antonella; Bonelli, Patrizia; Tuccillo, Franca Maria; Goldfine, Ira D.; Evans, Joseph L; Buonaguro, Franco M.; Mancini, Aldo

doi:10.1016/j.redox.2018.01.009

Cited by 220 publications

(195 citation statements)

References 183 publications

(207 reference statements)

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…Circulating levels of reduced glutathione, a major antioxidant (42,43), was 3-fold higher (P = 3 3 10 24 ) in RS-fed mice compared with NS-fed mice ( Table 1). Plasma glycine, which is necessary for glutathione synthesis, was significantly decreased in RS-fed mice by 0.37-fold (P = 1.6 3 10 22 ).…”

Section: Resultsmentioning

confidence: 97%

Ingestion of resistant starch by mice markedly increases microbiome‐derived metabolites

et al. 2019

View full text Add to dashboard Cite

Recent research has shown significant health benefits deriving from high‐dietary fiber or microbiome‐accessible carbohydrate consumption. Compared with native starch (NS), dietary resistant starch (RS) is a high microbiome‐accessible carbohydrate that significantly alters the gut microbiome. The aim of this study was to determine the systemic metabolic effects of high microbiome‐accessible carbohydrate. Male C57BL/6 mice were divided into 2 groups and fed either NS or RS for 18 wk (n = 20/group). Metabolomic analyses revealed that plasma levels of numerous metabolites were significantly different between the RS‐fed and NS‐fed mice, many of which are microbiome‐derived. Most strikingly, we observed a 22‐fold increase in gut microbiome‐derived tryptophan metabolite indole‐3‐propionate (IPA), which was positively correlated with several gut microbiota, including Allobaculum, Bifidobacterium, and Lachnospiraceae, with Allobaculum having the most consistently increased abundance of all the IPA‐associated taxa across all RS‐fed mice. In addition, major changes were observed for metabolites solely or primarily metabolized in the gut (e.g., trimethylamine‐N‐oxide), metabolites that have a significant entero‐hepatic circulation (i.e., bile acids), lipid metabolites (e.g., cholesterol sulfate), metabolites indicating increased energy turnover (e.g., tricarboxylic acid cycle intermediates and ketone bodies), and increased antioxidants such as reduced glutathione. Our findings reveal potentially novel mediators of high microbiome‐accessible carbohydrate‐derived health benefits.—Koay,Y. C., Wali. J. A., Luk, A. W. S., Macia, L., Cogger, V. C., Pulpitel, T. J., Wahl, D., Solon‐Biet, S. M., Holmes, A., Simpson, S. J., O'Sullivan, J. F. Ingestion of resistant starch by mice markedly increases microbiome‐derived metabolites. FASEB J. 33, 8033–8042 (2019). http://www.fasebj.org

show abstract

Section: Resultsmentioning

confidence: 97%

Ingestion of resistant starch by mice markedly increases microbiome‐derived metabolites

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Second, we assessed liver oxidative stress by analyzing antioxidant indices and lipid peroxidation biomarkers, including SOD, CAT, GSH-Px, GSH, and MDA. SOD, a critical antioxidant, can convert superoxide radical anions (O 2 − , incompletely reduced forms of oxygen) into hydrogen peroxide (H 2 O 2 ), which in turn is catalyzed into water by CAT and GSH-Px (Turrens, 2003;Borrelli et al, 2018). GSH as a non-enzymatic antioxidant can directly scavenge reactive oxygen species (ROS) by binding with them (Anu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Liu

et al. 2020

Front. Microbiol.

123

View full text Add to dashboard Cite

The global prevalence of obesity is rising year by year, which has become a public health problem worldwide. In recent years, animal studies and clinical studies have shown that some lactic acid bacteria possess an anti-obesity effect. In our previous study, mixed lactobacilli (Lactobacillus plantarum KLDS1.0344 and Lactobacillus plantarum KLDS1.0386) exhibited anti-obesity effects in vivo by significantly reducing body weight gain, Lee's index and body fat rate; however, its underlying mechanisms of action remain unclear. Therefore, the present study aims to explore the possible mechanisms for the inhibitory effect of mixed lactobacilli on obesity. C57BL/6J mice were randomly divided into three groups including control group (Control), high fat diet group (HFD) and mixed lactobacilli group (MX), and fed daily for eight consecutive weeks. The results showed that mixed lactobacilli supplementation significantly improved blood lipid levels and liver function, and alleviated liver oxidative stress. Moreover, the mixed lactobacilli supplementation significantly inhibited lipid accumulation in the liver and regulated lipid metabolism in epididymal fat pads. Notably, the mixed lactobacilli treatment modulated the gut microbiota, resulting in a significant increase in acetic acid and butyric acid. Additionally, Spearman's correlation analysis found that several specific genera were significantly correlated with obesity-related indicators. These results indicated that the mixed lactobacilli supplementation could manipulate the gut microbiota and its metabolites (acetic acid and butyric acid), resulting in reduced liver lipid accumulation and improved lipid metabolism of adipose tissue, which inhibited obesity.

show abstract

“…Further research is underway to better elucidate the role of gut microbiota on the pathogenesis of NAFLD. 97,98 Journal of Clinical and Translational Hepatology 2019 vol. 7 | 362-370 99 A plethora of studies report an association between NAFLD and these markers of preclinical atherosclerosis, with multiple systematic reviews and meta-analyses highlighting the association between NAFLD and carotid-artery intimamedia-thickness, coronary artery calcification and endothelial dysfunction, independent of traditional risk factors.…”

Section: Gut Microbiotamentioning

confidence: 99%

Pathogenesis of Insulin Resistance and Atherogenic Dyslipidemia in Nonalcoholic Fatty Liver Disease

Akhtar¹,

Iqbal²,

Vazquez‐Montesino³

et al. 2019

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the developed world, with a global prevalence of around 25%. NAFLD is considered to be the hepatic manifestation of metabolic syndrome and is strongly associated with obesity, insulin resistance and dyslipidemia. Insulin resistance plays a pivotal role in the development of NAFLD-related dyslipidemia, which ultimately increases the risk of premature cardiovascular diseases, a leading cause of morbidity and mortality in patients with NAFLD. Insulin affects hepatic glucose and lipid metabolism by hepatic or extrahepatic pathways. Aside from insulin resistance, several other factors also contribute to the pathogenesis of atherogenic dyslipidemia in patients with NAFLD. These include diet composition, gut microbiota and genetic factors, to name a few. The identification of potentially modifiable risk factors of NAFLD is of importance, so as to target those who may benefit from lifestyle changes and to help develop targeted therapies that decrease the risk of cardiovascular diseases in patients with NAFLD. Citation of this article: Akhtar DH, Iqbal U, Vazquez-Montesino LM, Dennis BB, Ahmed A. Pathogenesis of insulin resistance and atherogenic dyslipidemia in nonalcoholic fatty liver disease.Abbreviations: DNL, de novo lipogenesis; NAFLD, nonalcoholic fatty liver disease; SIBO, small intestinal bacterial overgrowth.

show abstract

Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches

Cited by 220 publications

References 183 publications

Ingestion of resistant starch by mice markedly increases microbiome‐derived metabolites

Ingestion of resistant starch by mice markedly increases microbiome‐derived metabolites

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Pathogenesis of Insulin Resistance and Atherogenic Dyslipidemia in Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About