Role of impaired gastric accommodation to a meal in functional dyspepsia

Tack, Jan; Piessevaux, Hubert; Coulie, Bernard; Caenepeel, Philip; Janssens, Jozef

doi:10.1016/s0016-5085(98)70012-5

Cited by 972 publications

(1,198 citation statements)

References 19 publications

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“…Scintigraphic and ultrasonographic studies have demonstrated an abnormal intragastric distribution of food in patients with functional dyspepsia, with preferential accumulation in the distal stomach, [29][30][31] and gastric barostat studies have confirmed reduced proximal gastric relaxation in response to a meal in patients with functional dyspepsia. 11,32 A relationship between impaired gastric accommodation and early satiety and weight loss has been reported by some 11,33,34 but has not been confirmed in other studies. 35 The prevalence of impaired accommodation is particularly high in patients with acute-onset dyspepsia, and this has been attributed to a defect at the level of gastric intrinsic nitrergic neurons.…”

Section: Impaired Gastric Accommodationmentioning

confidence: 87%

“…79 We have shown that administration of sumatriptan, a 5-HT 1 receptor agonist, also relaxes the proximal stomach in healthy subjects 80 and, in acute studies, is able to restore the meal-induced relaxation in patients with impaired gastric accommodation and to increase the amount of calories ingested at maximum satiety in patients with early satiety. 11 Because of its pharmacologic properties, its cost, and its mode of administration, sumatriptan is not suitable for chronic treatment of functional q 2005 Lippincott Williams & Wilkins dyspepsia. Buspirone is a nonselective 5-HT 1 receptor agonist, used in the treatment of panic attacks.…”

Section: Fundus-relaxing Drugsmentioning

confidence: 99%

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Pathophysiology and treatment of functional dyspepsia

2004

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Section: Impaired Gastric Accommodationmentioning

confidence: 87%

Section: Fundus-relaxing Drugsmentioning

confidence: 99%

Pathophysiology and treatment of functional dyspepsia

2004

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“…Traditionally, functional dyspepsia, in particular PDS, has been associated with disturbances in gastric motor function 47,48 . However, a study showed that gastric physiological disturbances did not correlate with symptoms 49 , and delayed gastric emptying presented to a similar extent in PDS, EPS and overlapping groups.…”

Section: Mechanisms/pathophysiologymentioning

confidence: 99%

“…The most widely used generic measure, the Short Form 36-Item Health Survey (SF-36) 222 , assesses eight dimensions of health: physical functioning, social functioning, Nature Reviews | Disease Primers Fatty foods , milk and dairy Alcohol , coffee Red meat Carbonated drinks Vegetables Spicy foods Carbohydrates and wheat (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) Citrus (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) Figure 5 | Foods and food groups frequently associated with symptom induction or exacerbation in functional dyspepsia. Offending foods reported by patients with functional dyspepsia include fatty food (for example, fried food [179][180][181]187,191 ), alcohol 179,180 , dairy products 179,181 , coffee [179]…”

Section: Quality Of Lifementioning

confidence: 99%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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“…The accommodation reflex consists of two components: receptive relaxation that occurs within seconds after the onset of gastric filling and adaptive relaxation, a process whereby stomach volume increases to twice the volume of a meal. Gastric accommodation has primarily been studied with the barostat (3,4).…”

mentioning

confidence: 99%

Gastric volume changes in response to a meal: Validation of magnetic resonance imaging versus the barostat

Haans

Zwart

Eilers

et al. 2011

Magnetic Resonance Imaging

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Purpose: To determine the accuracy of magnetic resonance imaging (MRI) volume scans: 1) to measure known meal volumes in vitro, and 2) to compare volume changes in response to a meal measured with the barostat with those measured with MRI in vivo.Materials and Methods: Polyethylene bags were filled with known volumes and MRI volume scans were performed to determine the accuracy of the volume measurements. Barostat measurements and MRI volume scans were performed simultaneously in 14 healthy subjects before and up to 90 minutes after ingestion of a liquid meal.Results: In vitro MRI-determined volumes showed an excellent linear relationship (r ¼ 0.995, P < 0.001) with actual meal volumes. Although fasting gastric volume, postprandial gastric volume, and relaxation volume measured with MRI were significantly larger compared to volumes measured with the barostat, volumes determined with both techniques showed excellent correlation.

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Role of impaired gastric accommodation to a meal in functional dyspepsia

Cited by 972 publications

References 19 publications

Pathophysiology and treatment of functional dyspepsia

Pathophysiology and treatment of functional dyspepsia

Functional dyspepsia

Gastric volume changes in response to a meal: Validation of magnetic resonance imaging versus the barostat

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