Role of individual structural features of rabbit kidneys in the predisposition to gentamicin nephrotoxicity

Бушма, К. М.; Kizyukevich, L. S.; Bushma, M. I.; Нечипоренко, Нина Александровна

doi:10.1007/s10517-005-0076-x

Cited by 2 publications

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“…However, their clinical use is limited by their side effects, and especially their high nephrotoxicity by reactive oxygen species and oxidative stress (1). Gentamicin nephrotoxicity has been reproduced in various experimental animal models (mice, rat and rabbit) (13)(14)(15), and numerous agents (1,16,17) have been studied in order to investigate their ability to reduce this nephrotoxicity. As reported by Badreldin HA et al, medicinal plants extracts, compounds from aged garlic, withania somnifera, sesame oil (sesamum indicum, antioxidant vitamins C and E), nitric oxide, and dihydropyridine calcium channel blockers are some of the agents that have been studied (18).…”

Section: Discussionmentioning

confidence: 99%

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods: Twenty four healthy male Wistar rats, weighing between 220 -260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group (Group I, n = 8), gentamicin injection with garlic supplementation group (Group II, n = 8), and control group (Group III, n = 8). Urine from the rats was collected and the volume (mLand pH values were measured. Then urea (mg/dL), creatinine (mg/dL), total protein (g/dL) and cystatin (mg/L) values were measured for the blood samples obtained from tail veins. Results:The median NAG value for the control group (52.050 U/L) was similar to value for Group II (56.400 U/L), which received gentamicin and the garlic diet. However, the median NAG value for Group I (77.030 U/L), which received gentamicin without garlic supplementation, was determined to be statistically significantly higher (p = 0.010) than the value for the control group. In addition, the mean cystatin value for Group II (1.360 U/L) was found to be statistically significantly lower than the value for the Group I (2.240 U/L) (p = 0.015).Conclusions: In this study we showed the effect of 4% pulverized garlic supplemented diet for preventing nephrotoxicity induced by gentamicin in rats by using as parameters NAG in urine samples and cystatin C in serum samples.

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Section: Discussionmentioning

confidence: 99%

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

et al. 2014

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“…It has been estimated that up to 30% of patients treated with GM for more than 7 days show some signs of renal impairment [3]. GM nephrotoxicity has been investigated in several experimental models in rabbits, mice and rats [4–6], and several strategies and agents have been used, with various degrees of success, in an attempt to protect or reverse renal GM damage [3,7,8]. This would be expected to have important clinical implications in increasing the safety of the drug.…”

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Experimental Gentamicin Nephrotoxicity and Agents that Modify it: A Mini-Review of Recent Research

Ali

Za’abi

Blunden

et al. 2011

Basic &Amp; Clinical Pharmacology &Amp; Toxicology

124

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Abstract:The aminoglycoside antibiotic gentamicin (GM) is still widely used against infections by Gram-positive and Gram-negative aerobic bacteria. Its therapeutic efficacy, however, is limited by renal impairment that occurs in up to 30% of treated patients. The drug may accumulate in epithelial tubular cells causing a range of effects starting with loss of the brush border in epithelial cells and ending in overt tubular necrosis, activation of apoptosis and massive proteolysis. GM also causes cell death by generation of free radicals, phospholipidosis, extracellular calcium-sensing receptor stimulation and energetic catastrophe, reduced renal blood flow and inflammation. Many drugs have been shown to either ameliorate or potentiate GM nephrotoxicity. This article aims at updating the literature that has been published in the past decade on the effects of agents that either ameliorate or augment the nephrotoxicity of this aminoglycoside. Notable among the new ameliorating procedures are gene therapy, such as intravenous cell therapy with serum amyloid A protein-programmed cells, and the use of some novel antioxidant agents and oils of natural origin. These include, for example, green tea, garlic saffron, grape seed extracts as well as sesame and oleanolic oils. Agents that may augment GM nephrotoxicity include indomethacin, cyclosporin, uric acid and the Ca ++ -channel blocker verapamil. Most of the nephroprotective agents mentioned here have not been tested in large controlled clinical trials. Because of their relative safety and effectiveness, antioxidant agents seem to be good candidates for testing in humans.The aminoglycoside antibiotics are used, either alone or in combination with cell wall-active agents, for the treatment of severe ⁄ life-threatening infections caused by Gram-positive and Gram-negative aerobes [1]. Gentamicin (GM) is probably the most commonly used and studied of all the aminoglycosides [2]. One serious limitation to the use of this antibiotic is that it can cause ototoxicity and nephrotoxicity, and, in some situations, these side effects are so severe that the use of the drug must be discontinued. It has been estimated that up to 30% of patients treated with GM for more than 7 days show some signs of renal impairment [3]. GM nephrotoxicity has been investigated in several experimental models in rabbits, mice and rats [4][5][6], and several strategies and agents have been used, with various degrees of success, in an attempt to protect or reverse renal GM damage [3,7,8]. This would be expected to have important clinical implications in increasing the safety of the drug. Because the pharmaceutical industry, in general, is not investing adequately in the development of new antibiotics, and antimicrobial resistance is on the increase, revival of older antibiotics for use might be a viable option. Some reviews have been published recently on specific aspects of GM nephrotoxicity. For example, Zorov [9] wrote about the role of renal mitochondria on protection against GM nephrotoxicity. Koyner...

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Role of individual structural features of rabbit kidneys in the predisposition to gentamicin nephrotoxicity

Abstract: A relationship between congenital features in the structure of rabbit kidneys and sensitivity to gentamicin nephrotoxicity was revealed. Gentamicin nephrotoxicity is more pronounced in rabbits with lower diameter of nephron convoluted tubules and with smaller cells lining their lumen.

Cited by 2 publications

References 1 publication

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats

Experimental Gentamicin Nephrotoxicity and Agents that Modify it: A Mini-Review of Recent Research

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