Role of leptin and adiponectin in gestational diabetes mellitus: a study in a North Indian tertiary care hospital

Saini, Vandana; Kataria, Megha; Yadav, Amita; Jain, Anju

doi:10.4314/ijmu.v10i1.3

Cited by 10 publications

(11 citation statements)

References 25 publications

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“…In our study, the levels of serum adiponectin were obviously lower in GDM subjects than healthy pregnant women and related adversely to blood glucose level. Saini et al [ 21 ] showed that adiponectin concentration was lower in pregnant women with GDM and found an inverse relationship between adiponectin level and fasting blood sugar. Also, we examined the effects of adiponectin concentration and Pre-pregnancy BMI and found that the risk of GDM was an independent factor of BMI.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study

Mohammadi

Paknahad

2017

Clin Nutr Res

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Gestational diabetes mellitus (GDM) is an impaired fasting glucose condition during pregnancy. Adiponectin is a polypeptide hormone that is extensively released by adipocytes which regulates energy homeostasis and carbohydrate and lipid metabolism. In addition, adiponectin has antidiabetic and anti-inflammatory properties. The aim of our research was to study about the relationship of adiponectin levels to GDM and glucose intolerance. We selected 25 GDM women and 35 healthy pregnant subjects (18–46 years) who were screened between 24 and 28 weeks of gestation based on the result of oral glucose tolerance test (OGTT). We designed a case-control study and measured the concentrations of serum adiponectin and compared the concentrations between the groups. Serum adiponectin concentration was measured using enzyme-linked immunosorbent assay (ELISA). Sociodemographic data were collected by personal interview. Serum adiponectin concentrations were significantly lower in the subjects with GDM (5.10 ± 2.15 ng/mL vs. 7.86 ± 3.52 ng/mL, p = 0.001) than in healthy pregnant subjects. The mean concentration of fasting blood glucose was considerably lower in control subjects (86.9 ± 9.0 mg/dL vs. 175.9 ± 20.1 mg/dL, p < 0.001) in comparison to GDM subjects. Our findings showed that serum concentrations of adiponectin were significantly lower in gestational diabetic women and this may help to predict the risk of GDM.

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Section: Discussionmentioning

confidence: 99%

Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study

Mohammadi

Paknahad

2017

Clin Nutr Res

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“…studied 30 GDM and 60 euglycemic pregnant women at 28 weeks of gestation and found significantly lower serum adiponectin levels in GDM. [5] We did not find any study from our country which has studied first trimester adiponectin levels.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Also, while there are a few studies from India which have reported lower adiponectin levels in diagnosed GDM women, there is none that has evaluated first trimester adiponectin levels as a biomarker to predict GDM. [45] This study attempts to assess the prediction of GDM by the first trimester serum adiponectin levels in a population of Indian women living in Delhi and adjoining areas.…”

Section: Introductionmentioning

confidence: 99%

Prediction of gestational diabetes from first trimester serum adiponectin levels in Indian Women

Madhu

Bhardwaj

Jhamb

et al. 2019

Indian J Endocr Metab

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Introduction:The prediction of gestational diabetes mellitus (GDM) by serum adiponectin levels has shown promise in Western literature. This study looks at the first trimester serum adiponectin levels as a predictor of gestational diabetes in Indian women.Material and Methods:A total of 450 pregnant women were screened at 11-- 13 weeks of gestation and serum samples were stored. All the women underwent an oral glucose tolerance test to diagnose GDM by International Association of Diabetes and Pregnancy study Group criteria at 24-- 28 weeks of gestation. Amongst these, 45 women who had developed GDM were compared with 45 controls. The first trimester serum adiponectin levels were compared between the two groups.Results:Mean first trimester adiponectin in GDM and non-GDM group was 7.21 ± 2.49 μg/ml and 12.20 ± 2.91 μg/ml, respectively (P < 0.001). Logistic regression revealed that low adiponectin was the strongest independent risk factor followed by body mass index and HbA1c. Receiver operating characteristic curve revealed that a cut-off value of adiponectin of 9.10 μg/ml in the first trimester was associated with a sensitivity of 100% and specificity of 95.6% in predicting GDM.Conclusions:This is the first study from India which has studied the prediction of GDM by first trimester adiponectin levels. First trimester serum adiponectin may be a strong predictor of GDM in Asian Indian women.

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“…[141516] A study from India has also shown lower adiponectin concentrations in women with gestational diabetes mellitus, compared to those having a normal pregnancy. [17] Previous studies have reported negative correlation between adiponectin level and BMI in both GDM and normoglycemic pregnant women. [101819] In our study, similar correlation could not be seen between the two groups possibly due to small sample size.…”

Section: Discussionmentioning

confidence: 99%

Serum adiponectin levels in gestational diabetes mellitus

Bhograj

Suryanarayana

Nayak

et al. 2016

Indian J Endocr Metab

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Introduction:Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.[1] Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24–28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women.Subjects and Methods:A total of 47 pregnant women in the age group of 18–40 years were included in this cross-sectional study, of which 13 were GDM cases and 34 were normoglycemic controls. Serum adiponectin level was analyzed by enzyme-linked immunosorbent assay.Results:The mean adiponectin level was 16.92 ng/ml (standard deviation [SD] = 2.78) and 19.38 ng/ml (SD = 2.71) in case and control groups, respectively, and the difference was found to be statistically significant (P = 0.008).Conclusion:Our study demonstrated decreased serum adiponectin levels in women with GDM when compared with age- and body mass index-matched euglycemic pregnant women.

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Role of leptin and adiponectin in gestational diabetes mellitus: a study in a North Indian tertiary care hospital

Cited by 10 publications

References 25 publications

Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study

Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study

Prediction of gestational diabetes from first trimester serum adiponectin levels in Indian Women

Serum adiponectin levels in gestational diabetes mellitus

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