Role of long non-coding RNAs in glucose metabolism in cancer

Fan, Chongxi; Tang, Yue; Wang, Jinpeng; Xiong, Fang; Guo, Can; Wang, Yumin; Zhang, Shanshan; Gong, Zhaojian; Fang, Wei; Yang, Liting; He, Yi; Zhou, Ming; Li, Xiaoling; Li, Guiyuan; Xiong, Wei; Zeng, Zhaoyang

doi:10.1186/s12943-017-0699-3

Cited by 161 publications

(140 citation statements)

References 116 publications

(102 reference statements)

Supporting

Mentioning

137

Contrasting

Order By: Relevance

“…This is concordant with recent evidence showing that MALAT1 has a direct oxygen-dependent regulation and could be a useful biomarker of tumor hypoxia [17, 18]. In solid tumors, upregulation of MALAT1 increases anaerobic glycolysis by potentiating the actions of HIF-1α through decreased HIF-1α ubiquitination [19]. In HeLa cells, it has been shown to control the HIF-1α axis under hypoxic conditions in a positive feedback loop [20].…”

Section: Discussionsupporting

confidence: 86%

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

et al. 2018

View full text Add to dashboard Cite

Background: Variable responses to hypothermic neuroprotection are related to the clinical heterogeneity of encephalopathic babies; hence better disease stratification may facilitate the development of individualized neuroprotective therapies. Objectives: We examined if whole blood gene expression analysis can identify specific transcriptome profiles in neonatal encephalopathy. Material and Methods: We performed next-generation sequencing on whole blood RNA from 12 babies with neonatal encephalopathy and 6 time-matched healthy term babies. Genes significantly differentially expressed between encephalopathic and control babies were identified. This set of genes was then compared to the host RNA response in septic neonates and subjected to pathway analysis. Results: We identified 950 statistically significant genes discriminating perfectly between healthy controls and neonatal encephalopathy. The major pathways in neonatal encephalopathy were axonal guidance signaling (p = 0.0009), granulocyte adhesion and diapedesis (p = 0.003), IL-12 signaling and production in macrophages (p = 0.003), and hypoxia-inducible factor 1α signaling (p = 0.004). There were only 137 genes in common between neonatal encephalopathy and bacterial sepsis sets. Conclusion: Babies with neonatal encephalopathy have striking differences in gene expression profiles compared with healthy control and septic babies. Gene expression profiles may be useful for disease stratification and for developing personalized neuroprotective therapies.

show abstract

Section: Discussionsupporting

confidence: 86%

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Moreover, the malignant progression and high mortality rates associated with these tumors are related to their insidious onset, frequent metastasis and recurrence, and poor prognosis . Treatment on the basis of early diagnosis is still the main approach for achieving long‐term cancer‐free survival . Although many biomarkers of malignant tumors are currently used in the clinical setting, all of these biomarkers have limitations.…”

Section: Discussionmentioning

confidence: 99%

“…[29][30][31] Treatment on the basis of early diagnosis is still the main approach for achieving long-term cancer-free survival. [32][33][34][35][36] Although many biomarkers of malignant tumors are currently used in the clinical setting, all of these biomarkers have limitations. Therefore, many studies have focused on identifying more effective biomarkers to improve the early diagnosis of ma- 55 Moreover, hsa_circ_0033155 could serve as a biomarker or therapeutic target in non-small-cell lung cancer.…”

Section: Discussionmentioning

confidence: 99%

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

et al. 2019

Self Cite

View full text Add to dashboard Cite

Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real‐time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ2 tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.

show abstract

“…6,7 An increasing number of studies have showed that lncRNAs function as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miR-NAs) to participate in the occurrence and development of multiple types of human tumors. 6,7 An increasing number of studies have showed that lncRNAs function as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miR-NAs) to participate in the occurrence and development of multiple types of human tumors.…”

Section: Introductionmentioning

confidence: 99%

LINC00461 promotes cell migration and invasion in breast cancer through miR‐30a‐5p/integrin β3 axis

Dong

Qian

Chen

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Mounting evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated and implicated in the occurrence and development of a wide range of human malignancies. LINC00461, a novel cancer‐related lncRNA, has been reported to be highly expressed and serve as oncogene in glioma; however, its biological role in breast cancer (BC) remains obscure. This study aimed to explore the role of LINC00461 in BC and elucidate the potential molecular mechanisms involved. In the current study, LINC00461 was found to be significantly upregulated in both BC tissues and cell lines. Besides, we found that high LINC00461 expression was associated with TNM stage and differentiation. Furthermore, functional studies demonstrated that LINC00461 expedited BC cell migration and invasion. Notably, LINC00461 was observed to enhance the expression of vimentin and zinc‐finger E‐box binding homeobox factor 1, suppress the expression of E‐cadherin, and promote the activation of extracellular signal‐regulated kinase and AKT signaling pathways. Mechanical investigations revealed that LINC00461 positively modulated integrin β3 (ITGB3) expression as miR‐30a‐5p sponge in BC cells. Taken together, LINC00461 exerts an oncogenic role in BC through miR‐30a‐5p/ITGB3 axis. Our data indicate that LINC00461 may be used to be a novel candidate therapeutic target and a valuable diagnostic biomarker for BC.

show abstract

Role of long non-coding RNAs in glucose metabolism in cancer

Cited by 161 publications

References 116 publications

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

circMAN1A2 could serve as a novel serum biomarker for malignant tumors

LINC00461 promotes cell migration and invasion in breast cancer through miR‐30a‐5p/integrin β3 axis

Contact Info

Product

Resources

About