Role of long noncoding RNA UCA1 as a common molecular marker for lymph node metastasis and prognosis in various cancers: a meta-analysis

He, Anbang; Hu, Rong; Chen, Zhicong; Liao, Xin; Li, Jianfa; Wang, Dailian; Lv, Zhaojie; Liu, Yuchen; Wang, Feng; Mei, Hongbing

doi:10.18632/oncotarget.12463

Cited by 32 publications

(28 citation statements)

References 14 publications

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“…Consistently, other lncRNAs such as HOTAIR , H19 and UCA1 were also found to predict the shorter OS in cancer patients [9, 26, 27]. In the future study, analysis of more than one lncRNAs may represent a better solution for predicting OS in cancer patients.…”

Section: Discussionmentioning

confidence: 69%

Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis

et al. 2017

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Recent studies have emphasized the important role of long non-coding RNAs (lncRNAs) in cancer development. The present study performed a meta-analysis to investigate whether lncRNA, SPRY4 Intronic Transcript 1(SPRY4-IT1) can be served as a potential biomarker for prognosis in human cancers. The eligible studies were collected by searching multiple online databases (Pubmed, EMBASE, CNKI, Web of Science and Google Scholar) and meta-analysis was performed to explore the association between the expression levels of SPRY4-IT1 and overall survival (OS), disease-free survival (DFS) and clinicopathological parameters. A total of 1329 patients from 13 studies were included for meta-analysis. The meta-analysis results showed that high expression level of SPRY4-IT1 was significantly associated with shorter OS in cancer patients (HR = 3.20, 95% CI: 2.59-3.90, P<0.001) except in the patients with non-small cell lung cancer (NSCLC). Increased SPRY4-IT1 expression level was correlated with shorter DFS in patients with gastric cancer and ovarian cancer. SPRY4-IT1 expression level was not correlated with the clinicopathological parameters including age (P = 0.37), gender (P = 0.87), tumor size (P = 0.47) and invasion depth (P = 0.52), and increased SPRY4-IT1 expression level was significantly associated with distant metastasis (odds ratio (OR) = 1.96, 95% CI: 1.24-3.08, P = 0.004), lymph node metastasis (OR = 3.96, 95% CI: 1.48-5.54, P<0.001), advanced tumor/node/metastasis stage (OR = 3.72, 95% CI = 2.91-4.76, P<0.001) and poor tumor differentiation (OR = 1.86, 95% CI = 1.35-2.58, P<0.001) in cancer patients except in patients with NSCLC. In summary, the meta-analysis results suggested that increased expression level of SPRY4-IT1 was positively associated with unfavorable prognosis and advanced features of cancers in cancer patients but not in patients with NSCLC.

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Section: Discussionmentioning

confidence: 69%

Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis

et al. 2017

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“…Owing to their various functions in the pathogenesis of diseases, lncRNAs have been widely studied in different types of tumors . Among the diverse kinds of lncRNAs, antisense lncRNAs attract more and more investigations.…”

Section: Discussionmentioning

confidence: 99%

“…In the past 25 years, owing to combination therapy of surgical therapy and chemotherapy, the five‐year tumor‐free survival rate of OS has been raised up to 60%‐75% . However, those who with metastasis and local recurrence still have a poor clinical prognosis . Thus, it is exigent for clinical surgeons to find out effective strategies for early diagnosis, treatment, and prognosis of OS.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA DNAJC3‐AS1 promotes osteosarcoma progression via its sense‐cognate gene DNAJC3

et al. 2019

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Long noncoding RNAs have been proved to play essential roles in tumor development and progression. In this study, we focused on DNAJC3‐AS1 and investigated its biological function and clinical significance in osteosarcoma. We detected the expression of DNAJC3‐AS1 in 30 pairs of matched osteosarcoma and adjacent nontumorous specimens and osteosarcoma cell lines and analyzed association between DNAJC3‐AS1 levels and clinicopathological factors. We found that DNAJC3‐AS1 expression was up‐regulated in osteosarcoma. High level of DNAJC3‐AS1 was correlated with high differentiated degree (P = 0.018) and advanced Enneking stage (P = 0.016). Mechanistically, DNAJC3‐AS1 enhanced cell proliferation, migration, and invasion in vitro and in vivo and reduced sensitivity of osteosarcoma to cisplatin. These effects of DNAJC3‐AS1 were reversed by down‐regulation of its sense‐cognate gene DNAJC3. Thus, DNAJC3‐AS1 promotes osteosarcoma development and progression by regulating DNAJC3 and might be a biomarker and therapeutic target for osteosarcoma.

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“…18,19 As an important member of lncRNAs, UCA1 has been widely reported in various cancers and has received considerable attention from scholars. 20 Evidence from Han et al 21 pathway via regulating TIMP2 expression. SUN-216 cells were transfected with sh-UCA1#2 and si-TIMP2, and the key factors of the NF-κB signal pathway were detected by Western blot analysis.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Knockdown of long noncoding RNA urothelial carcinoma–associated 1 inhibits cell viability, migration, and invasion by regulating microRNA‐182 in gastric carcinoma

Qin

Jia

Xie

et al. 2018

J of Cellular Biochemistry

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Role of long noncoding RNA UCA1 as a common molecular marker for lymph node metastasis and prognosis in various cancers: a meta-analysis

Abstract: ABSTRACT

Cited by 32 publications

References 14 publications

Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis

Prognostic role of the long non-coding RNA, SPRY4 Intronic Transcript 1, in patients with cancer: a meta-analysis

Long noncoding RNA DNAJC3‐AS1 promotes osteosarcoma progression via its sense‐cognate gene DNAJC3

Retracted: Knockdown of long noncoding RNA urothelial carcinoma–associated 1 inhibits cell viability, migration, and invasion by regulating microRNA‐182 in gastric carcinoma

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