Role of Machine Learning in Wrist Pulse Analysis

Kumar, Sachin; Pooja, .; Kumar, Suresh; Veer, Karan

doi:10.1002/9781119861850.ch15

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…β-Cyclodextrin-based NSs were synthesized using a previously reported melting method. 45 Three β-CD NSs were prepared using different β-CD/DPC molar ratios (1:2, 1:4, and 1:8). DPC was melted and further mixed with β-CD, following magnetic stirring at 90 °C for 5 h. The obtained NSs were washed thoroughly with deionized water and ethanol to remove the unreacted precursors.…”

Section: Preparation Of Mnps and Nssmentioning

confidence: 99%

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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A β-cyclodextrin (β-CD) nanosponge (NS) was synthesized using diphenyl carbonate (DPC) as a cross-linker to encapsulate the antitumor drug cyclophosphamide (CYC), thus obtaining the NSs-CYC system. The formulation was then associated with magnetite nanoparticles (MNPs) to develop the MNPs-NSs-CYC ternary system. The formulations mentioned above were characterized to confirm the deposition of the MNPs onto the organic matrix and that the superparamagnetic nature of the MNPs was preserved upon association. The association of the MNPs with the NSs-drug complex was confirmed through field emission scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, dynamic light scattering, ζ-potential, atomic absorption spectroscopy, X-ray powder diffraction, selected area electron diffraction, and vibrating-sample magnetometer. The superparamagnetic properties of the ternary system allowed the release of CYC by utilizing magnetic hyperthermia upon the exposure of an alternating magnetic field (AMF). The drug release experiments were carried out at different frequencies and intensities of the magnetic field, complying with the "Atkinson−Brezovich criterion". The assays in AMF showed the feasibility of release by controlling hyperthermia of the drug, finding that the most efficient conditions were F = 280 kHz, H = 15 mT, and a concentration of MNPs of 5 mg/mL. CYC release was temperature-dependent, facilitated by local heat generation through magnetic hyperthermia. This phenomenon was confirmed by DFT calculations. Furthermore, the ternary systems outperformed the formulations without MNPs regarding the amount of released drug. The MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assays demonstrated that including CYC within the magnetic NS cavities reduced the effects on mitochondrial activity compared to those observed with the free drug. Finally, the magnetic hyperthermia assays showed that the tertiary system allows the generation of apoptosis in HeLa cells, demonstrating that the MNPs embedded maintain their properties to generate hyperthermia. These results suggest that using NSs associated with MNPs could be a potential tool for a controlled drug delivery in tumor therapy since the materials are efficient and potentially nontoxic.

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Section: Preparation Of Mnps and Nssmentioning

confidence: 99%

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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“…To reduce skin irritation, the implementation of non-ionic and PEG-free surfactants has been shown to be effective in constructing SLN [191,192]. Furthermore, SLN have been used in topical applications and cosmetics to mitigate the toxic effects of bioactive compounds by reinforcing the lipid film of the stratum corneum and repairing damaged skin [193]. Considering the physicochemical properties of the constituents of SLN can help ensure the safe and effective use of this nanostructured material in cosmeceuticals.…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Functional Nanostructured Materials in the Cosmetics Industry: A Review

et al. 2023

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Cosmetics have always been in demand across the globe among people of all age groups. In the modern cosmetic world, nanostructured materials have proven hugely advantageous in producing cosmeceuticals or ‘nano-cosmeceuticals’ and various beauty products. The application of nanostructured materials in cosmetic products possesses some challenges in terms of short- and long-term safety and environmental issues, despite their growing popularity. The nanostructured particles in cosmeceuticals provide a targeted route of administration due to their high penetrability, site selectivity, high effectiveness, prolonged activity, and drug encapsulation potential. However, standard methods for toxicity evaluation may not be relevant for cosmeceuticals, leading to the need for an alternative methodology. This review article compiles detailed descriptions of all significant aspects of nanostructured materials in the cosmetics industry, which include the synthesis and characterization of relevant nanostructured materials for cosmeceuticals, state-of-the-art practices, mechanisms for the synthesis of advanced materials, toxicological concerns in terms of health risks in humans, and environmental concerns. Also, a proposal for new approaches in terms of regulatory measures to mitigate these problems has been suggested. The primary focus of this article is to provide a comprehensive outlook on this subject area and contribute to the exploration of new prospects and emerging roles of nanostructured materials in the cosmetics industry.

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“…Norfloxacin [291], kynurenic acid [292], tamoxifen [293], rilpivirine [294], acyclovir [295], camptothecin [296], telmisartan [297], babchi oil [298], chrysin [299], paclitaxel [277], sulfamethoxazole [300], ferulic acid [301], melatonin [44], D-limonene [302], azelaic acid [303], paliperidone [304], griseofulvin [305], flutamide [306], econazole nitrate [307], piperine [308], etc., are several other drugs loaded in carbonate CD-NSs. In all these findings it was observed an enhancement of the biocompatibility and aqueous solubility of the aforementioned drugs when they are loaded in NSs compare to CD-inclusion complexes or uncomplexed drugs.…”

Section: Cyclodextrin-based Carbonate Nanospongesmentioning

confidence: 99%

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Hoti

Pedrazzo

Cecone

et al. 2022

IJMS

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Nutraceuticals are bioactive or chemical compounds acclaimed for their valuable biological activities and health-promoting effects. The global community is faced with many health concerns such as cancers, cardiovascular and neurodegenerative diseases, diabetes, arthritis, osteoporosis, etc. The effect of nutraceuticals is similar to pharmaceuticals, even though the term nutraceutical has no regulatory definition. The usage of nutraceuticals, to prevent and treat the aforementioned diseases, is limited by several features such as poor water solubility, low bioavailability, low stability, low permeability, low efficacy, etc. These downsides can be overcome by the application of the field of nanotechnology manipulating the properties and structures of materials at the nanometer scale. In this review, the linear and cyclic dextrin, formed during the enzymatic degradation of starch, are highlighted as highly promising nanomaterials- based drug delivery systems. The modified cyclic dextrin, cyclodextrin (CD)-based nanosponges (NSs), are well-known delivery systems of several nutraceuticals such as quercetin, curcumin, resveratrol, thyme essential oil, melatonin, and appear as a more advanced drug delivery system than modified linear dextrin. CD-based NSs prolong and control the nutraceuticals release, and display higher biocompatibility, stability, and solubility of poorly water-soluble nutraceuticals than the CD-inclusion complexes, or uncomplexed nutraceuticals. In addition, the well-explored CD-based NSs pathways, as drug delivery systems, are described. Although important progress is made in drug delivery, all the findings will serve as a source for the use of CD-based nanosystems for nutraceutical delivery. To sum up, our review introduces the extensive literature about the nutraceutical concepts, synthesis, characterization, and applications of the CD-based nano delivery systems that will further contribute to the nutraceutical delivery with more potent nanosystems based on linear dextrins.

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Role of Machine Learning in Wrist Pulse Analysis

Cited by 4 publications

References 60 publications

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Functional Nanostructured Materials in the Cosmetics Industry: A Review

Nutraceutical Concepts and Dextrin-Based Delivery Systems

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