Role of margin status in recurrence after CO<sub>2</sub>laser endoscopic resection of early glottic cancer

Crespo, Agrício Nubiato; Chone, Carlos Takahiro; Gripp, Flávio M.; Spina, Ana L.; Altemani, Albina

doi:10.1080/00016480500316985

Cited by 76 publications

(12 citation statements)

References 33 publications

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“…Only 22 (40%) of the re-resection specimens were positive. Other authors have seen similar results in smaller studies [9], [10], [11], [12]. In our view a "wait and watch" policy should only be chosen, if the patient was fully informed about the pros and cons.…”

Section: Early Glottic Carcinomassupporting

confidence: 75%

Functional organ preservation in laryngeal and hypopharyngeal cancer

Ambrosch,

Fazel

2011

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 10:Doc02; ISSN 1865-1011

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Section: Early Glottic Carcinomassupporting

confidence: 75%

Functional organ preservation in laryngeal and hypopharyngeal cancer

Ambrosch,

Fazel

2011

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 10:Doc02; ISSN 1865-1011

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“…Frozen section has in the past been advocated; however, we feel it does not add to the intraoperative management. It may be helpful to send separate specimens from the edge of the resected area which is macroscopically clear of tumour [8]. Transoral laser microsurgery, therefore, relies heavily on the surgeon making a competent assessment of the resection.…”

Section: Discussionmentioning

confidence: 99%

Transoral Laser Microsurgery for Early Glottic Cancer

McClelland

Carr

Kamani

et al. 2011

ISRN Otolaryngology

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Objectives. To assess the outcome of transoral laser-assisted microsurgery (TLM) with regards to local and distant tumour control, quality of voice and swallowing. Design. Retrospective review of patients with five-year follow-up period. Setting. Royal Derby Hospital Head and Neck Department. Participants. All patients undergoing TLM with a diagnosis of Tis, T1, or T2 glottic tumour following endoscopic biopsy. Main Outcome Measures. Speech, swallowing, cancer-free survival, laryngectomy-free survival, and mortality rate. Results. 22 patients were treated for early glottic carcinoma with TLM. The 5-year local control rate for T1 tumours is 89% and 56% for T2 tumours. The laryngectomy rate was 4.5%. The mortality rate from local and distant disease was 4.5% with an overall mortality rate of 22% from all causes. 40% of patients had normal voices and a further 45% had only mild or moderate voice change. At their last followup, no patients assessed had any difficulty swallowing relating to their treatment for glottic cancer. Conclusion. Transoral Endoscopic CO2 laser microsurgery is a valid technique for treating early glottic tumours.

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“…Others preferred a wait and see attitude but performed several second-look procedures, on clinical indication [68–70] or using the site of the positive margins (deep versus superficial) to decide whether a patient should be re-excised or not [32]. Re-treatment with either TLM or radiotherapy was standard only for three authors [71–73], although not all patients were handled according to protocol, mainly because of patients’ preference. As a result, there were two studies in which positive/inadequate margins were handled with re-treatment in the majority of cases [69, 72].…”

Section: Factors Affecting Oncological Outcomes Of Tlmmentioning

confidence: 99%

Transoral Laser Microsurgery in Early Glottic Lesions

Sjögren

2017

Curr Otorhinolaryngol Rep

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Purpose of ReviewTo give an overview of the evolvement of transoral laser microsurgery (TLM) in the treatment of early glottic carcinoma and highlight the contribution of recent literature.Recent FindingsThe indications and limits of TLM have been well specified. Effects on swallowing have been well documented. Introduction of narrow-band imaging (NBI) and diffusion-weighted magnetic resonance has been shown of additional value for outcome. The first reports on transoral robotic surgery show that it may be of added value in the future.SummaryTLM for early glottic carcinoma (Tis–T2) has very good oncological outcomes with indications of higher larynx preservation in TLM than that in radiotherapy. The anterior commissure is a risk factor if involved in the cranio-caudal plane, and reduced vocal fold mobility is a risk factor when this is due to arytenoid involvement. The best voice results are achieved when the anterior commissure can be left intact along with part of the vocal fold muscle although even in larger resections, patient self-reported voice handicap is still limited.

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Role of margin status in recurrence after CO₂laser endoscopic resection of early glottic cancer

Cited by 76 publications

References 33 publications

Functional organ preservation in laryngeal and hypopharyngeal cancer

Functional organ preservation in laryngeal and hypopharyngeal cancer

Transoral Laser Microsurgery for Early Glottic Cancer

Transoral Laser Microsurgery in Early Glottic Lesions

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Role of margin status in recurrence after CO2laser endoscopic resection of early glottic cancer

Cited by 76 publications

References 33 publications

Functional organ preservation in laryngeal and hypopharyngeal cancer

Functional organ preservation in laryngeal and hypopharyngeal cancer

Transoral Laser Microsurgery for Early Glottic Cancer

Transoral Laser Microsurgery in Early Glottic Lesions

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Role of margin status in recurrence after CO₂laser endoscopic resection of early glottic cancer