Role of MaxiK channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery

Tanaka, Yoshio; Mochizuki, Yumi; Hirano, Haruko; Aida, Miwako; Tanaka, Hikaru; Toro, Ligia; Shigenobu, Koki

doi:10.1016/s0014-2999(99)00647-0

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…Pharmacological inhibition of BKCa also antagonizes the response to GPCR agonists (Table 4), cAMP mimetics (Armstead, 1997a;Barman, 1997;Paterno, et al, 1996;Taguchi, et al, 1995;Tanaka, et al, 1999), or FSK (Taguchi, et al, 1995), which shows that the cAMP-BKCa channel axis is an important contributing mechanism to vasodilatory response evoked by the cAMP pathway. This was not observed, however, in some reports (Khan, et al, 1993).…”

Section: Regulation Of Bkca Channels By Camp Pathwaysmentioning

confidence: 88%

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Manoury

Idres

Leblais

et al. 2020

Pharmacology & Therapeutics

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Numerous mediators and drugs regulate blood flow or arterial pressure by acting on vascular tone, involving cyclic nucleotide intracellular pathways. These signals lead to regulation of several cellular effectors, including ion channels that tune cell membrane potential, Ca 2+ influx and vascular tone. The characterization of these vasocontrictive or vasodilating mechanisms has grown in complexity due to i) the variety of ion channels that are expressed in both vascular endothelial and smooth muscle cells, ii) the heterogeneity of responses among the various vascular beds, and iii) the number of molecular mechanisms involved in cyclic nucleotide signalling in health and disease. This review synthesizes key data from literature that highlight ion channels as physiologically relevant effectors of cyclic nucleotide pathways in the vasculature, including the characterization of the molecular mechanisms involved. In smooth muscle cells, cation influx or chloride efflux through ion channels are associated with vasoconstriction, whereas K + efflux repolarizes the cell membrane potential and mediates vasodilatation. Both categories of ion currents are under the influence of cAMP and cGMP pathways. Evidence that some ion channels are influenced by CN signalling in endothelial cells will also be presented.Emphasis will also be put on recent data touching a variety of determinants such as phosphodiesterases, EPAC and kinase anchoring, that complicate or even challenge former paradigms.

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Section: Regulation Of Bkca Channels By Camp Pathwaysmentioning

confidence: 88%

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Manoury

Idres

Leblais

et al. 2020

Pharmacology & Therapeutics

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“…Dilation or relaxation induced by the adenylate cyclase activator, forskolin (90, 961, 1110, 1169, 1371); the cell-permeant cAMP analog, dibutyryl cAMP (1139, 1383); or receptor-mediated agonists such as adenosine (191, 201, 1139); di-adenosine poly phosphate (1354); CGRP (617); isoproterenol (961, 1254); iloprost (1270); prostacyclin (60); PGE 2 (60); vasoactive intestinal polypeptide (VIP) (1383); adenylate-cyclase-activating peptides (178); and 11,12-EET (642) are all inhibited by iberiotoxin, charybdotoxin and/or TEA (1 mmol/L).…”

Section: Bkca Channelsmentioning

confidence: 99%

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Tykocki

Boerman

Jackson

2017

Comprehensive Physiology

283

347

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Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body’s tissues and organs. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca2+ concentration, the primary determinant of SMC contractile activity and vascular tone. Ion channels provide the main source of activator Ca2+ that determines vascular tone, and strongly contribute to setting and regulating membrane potential, which, in turn, regulates the open-state-probability of voltage gated Ca2+ channels (VGCCs), the primary source of Ca2+ in resistance artery and arteriolar SMCs. Ion channel function is also modulated by vasoconstrictors and vasodilators, contributing to all aspects of the regulation of vascular tone. This review will focus on the physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ (BKCa) channels, strong-inward-rectifier K+ (KIR) channels, ATP-sensitive K+ (KATP) channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels that contribute to pressure-induced myogenic tone in resistance arteries and arterioles, the modulation of the function of these ion channels by vasoconstrictors and vasodilators, their role in the functional regulation of tissue blood flow and their dysfunction in diseases such as hypertension, obesity, and diabetes.

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“…The inhibitory actions of VIP and PACAP on contractions of some smooth muscles have been attributed, in part, to increased open probability (NP o ) of Ca 2ϩ -activated K ϩ (K Ca ) channels (6,19,39,42). In these studies, relaxation or hyperpolarization responses to VIP and PACAP were diminished by blocking K Ca channels with apamin and/or charybdotoxin.…”

Section: Discussionmentioning

confidence: 99%

VIP and PACAP regulate localized Ca²⁺ transients via cAMP-dependent mechanism

Hagen¹,

Bayguinov²,

Sanders³

2006

American Journal of Physiology-Cell Physiology

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Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have been suggested as participants in enteric inhibitory neural regulation of gastrointestinal motility. These peptides cause a variety of postjunctional responses including membrane hyperpolarization and inhibition of contraction. Neuropeptides released from enteric motor neurons can elicit responses by direct stimulation of smooth muscle cells as opposed to other transmitters that rely on synapses between motor nerve terminals and interstitial cells of Cajal. Therefore, we studied the responses of murine colonic smooth muscle cells to VIP and PACAP(1-38) with confocal microscopy and patch-clamp technique. Localized Ca2+ transients (Ca2+ puffs) were observed in colonic myocytes, and these events coupled to spontaneous transient outward currents (STOCs). VIP and PACAP increased Ca2+ transients and STOC frequency and amplitude. Application of dibutyryl cAMP had similar effects. The adenylyl cyclase blocker MDL-12,330A alone did not affect spontaneous Ca2+ puffs and STOCs but prevented responses to VIP. Disruption of A-kinase-anchoring protein (AKAP) associations by application of AKAP St-Ht31 inhibitory peptide had effects similar to those of MDL-12,330A. Inhibition of ryanodine receptor channels did not block spontaneous Ca2+ puffs and STOCs but prevented the effects of dibutyryl cAMP. These findings suggest that regulation of Ca2+ transients (which couple to activation of STOCs) may contribute to the inhibitory effects of VIP and PACAP. Regulation of Ca2+ transients by VIP and PACAP occurs via adenylyl cyclase, increased synthesis of cAMP, and PKA-dependent regulation of ryanodine receptor channels.

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Role of MaxiK channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery

Cited by 9 publications

References 21 publications

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

VIP and PACAP regulate localized Ca²⁺ transients via cAMP-dependent mechanism

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Role of MaxiK channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery

Cited by 9 publications

References 21 publications

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

VIP and PACAP regulate localized Ca2+ transients via cAMP-dependent mechanism

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Product

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VIP and PACAP regulate localized Ca²⁺ transients via cAMP-dependent mechanism