Role of non-coding RNAs in the progression and resistance of cutaneous malignancies and autoimmune diseases

Khan, Abdul Quaiyoom; Faried, Ahmad; Raza, Syed Shadab; Zarif, Lubna; Siveen, Kodappully Sivaraman; Sher, Gulab; Agha, Maha Victor; Rashid, Khalid; Kuliński, Michał; Buddenkotte, Joerg; Uddin, Shahab; Steinhoff, Martin

doi:10.1016/j.semcancer.2020.07.003

Cited by 25 publications

(25 citation statements)

References 266 publications

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“…miRNAs are epigenetic regulators~22 nucleotides in length and function as intracellular regulators of gene expression at the post-transcriptional level by inducing transcription degradation or retarding RNA transferase activity through binding to a 30-untranslated region (30-UTR) of target mRNA [12], modification of histone [12], or modulation of methylation in the DNA promoter regions [12,73]. A single miRNA can regulate and/or silence the expression of hundreds of genes, while multiple miRNAs can regulate the expression of a single gene [74,75]. circRNAs are a newly recognized group of ncRNAs characterized by distinctive profiles of conservation, stability, specificity, and complexity [54].…”

Section: Lncrnasmentioning

confidence: 99%

“…(ii) keratinocyte differentiation; (iii) melanocyte functions; as well as (iv) differentiation and activation of immune cells (Figure 2) [75,102].…”

Section: Lncrnas In Systemic Sclerosismentioning

confidence: 99%

“…Additionally, they may interact with proteins [ 79 ] or form pseudogenes by retrotranscribing and integrating them into the genome [ 54 , 80 ]. Increased levels of circRNAs in human body fluids can be used as biomarkers of various diseases, including cancer [ 75 , 81 ]. piRNAs are 26–32-nucleotides-long ncRNAs that play a crucial role in development, epigenetic regulation, and transposon silencing [ 75 , 82 ].…”

Section: Non-coding Rnasmentioning

confidence: 99%

“…Increased levels of circRNAs in human body fluids can be used as biomarkers of various diseases, including cancer [ 75 , 81 ]. piRNAs are 26–32-nucleotides-long ncRNAs that play a crucial role in development, epigenetic regulation, and transposon silencing [ 75 , 82 ]. piRNAs are regulators of gene expression primarily present in germ cells, and demonstrate a strong tendency for uridine (U) at the 5′ end [ 75 ].…”

Section: Non-coding Rnasmentioning

confidence: 99%

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Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine

Rusek

Krasowska

2021

Genes

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Epigenetic factors are heritable and ultimately play a role in modulating gene expression and, thus, in regulating cell functions. Non-coding RNAs have growing recognition as novel biomarkers and crucial regulators of pathological conditions in humans. Their characteristic feature is being transcribed in a tissue-specific pattern. Now, there is emerging evidence that lncRNAs have been identified to be involved in the differentiation of human skin, wound healing, fibrosis, inflammation, and immunological response. Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by fibrosis, vascular abnormalities, and immune system activation. The pathogenesis remains elusive, but clinical manifestations reveal autoimmunity with the presence of specific autoantibodies, activation of innate and adaptive immunity, vascular changes, and active deposition of extracellular matrix components leading to fibrosis. The use of multi-omics studies, including NGS, RNA-seq, or GWAS, has proposed that the non-coding genome may be a significant player in its pathogenesis. Moreover, it may unravel new therapeutic targets in the future. The aim of this review is to show the pathogenic role of long non-coding RNAs in systemic sclerosis. Investigation of these transcripts’ functions has the potential to elucidate the molecular pathology of SSc and provide new opportunities for drug-targeted therapy for this disorder.

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Section: Lncrnasmentioning

confidence: 99%

“…(ii) keratinocyte differentiation; (iii) melanocyte functions; as well as (iv) differentiation and activation of immune cells (Figure 2) [75,102].…”

Section: Lncrnas In Systemic Sclerosismentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

Section: Non-coding Rnasmentioning

confidence: 99%

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Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine

Rusek

Krasowska

2021

Genes

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“…An increasing number of studies have observed multiple functions of circRNAs, but the most noteworthy is the role of microRNA sponges: the competitive endogenous RNA (ceRNA) hypothesis proposes that circRNAs competitively bind to microRNA through microRNA response elements (MERs) to regulate downstream gene expression. It has been reported that circRNAs are involved in regulating the pathogenesis of various autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [7,8]. Nevertheless, the exploration of circRNAs in the pathogenesis of GD is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of CircRNA Expression and Associated ceRNA Network in Graves’ Disease

Jiang¹,

Huang²,

Chen³

et al. 2021

Preprint

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ObjectiveGraves’ disease (GD) is the most common subtype of autoimmune thyroid disease which have the involvement of circular RNAs (circRNAs) in the pathogenesis. However, it is largely unknown about the role of circRNAs in GD. In present study, we performed a comprehensive study of the circRNAs in GD by bioinformatics analyses.MethodsCircRNAs were detected in plasma of 3 newly diagnosed GD patients and 3 healthy controls. We selected 2 up-regulated and 1 down-regulated circRNAs with different expression in GD for validation by transcriptase-quantitative polymerase chain reaction in both GD and healthy control subjects. The GTRD base was used for predicting the transcript factors of the different expression of circRNAs. Then the competing endogenous RNAs(ceRNAs) network was assembled and the analysis of the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were performed to predict the functions of different expression of circRNAs.ResultsA total of 366 different expression of circRNAs were detected in GD. The exonic circRNA hsa_circ_0090364 was validated as an up-regulated molecule in GD. 82 transcript factors in promoter region for hsa_circ_0090364 were predicted. The ceRNAs network revealed that the miR-378 family members acted as the target microRNAs of hsa_circ_0090364 and its downstream genes, and also unveiled the involvement of hsa_circ_0090364 in pathogenesis of GD.ConclusionsHsa_circ_0090364 might play a role of ceRNA through sponging up miR-378 family members, which demonstrated that circRNAs had an effect on regulation in GD.

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Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review

Zamanian,

Shahbazi,

Kazmi

et al. 2024

Food Science & Nutrition

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Nonmelanoma skin cancer (NMSC) represents the most prevalent form of skin cancer globally, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being the most common types. The search for effective chemopreventive and therapeutic agents has led to the exploration of natural compounds, among which resveratrol (RES), a polyphenolic phytoalexin found in grapes, berries, peanuts, and red wine, has garnered significant attention. This comprehensive review aims to elucidate the effects of RES on NMSC, focusing on its mechanisms of action, efficacy in preclinical studies, and potential as a chemopreventive and therapeutic agent. RES exhibits promising chemopreventive and antineoplastic capabilities against NMSC through various mechanisms, including the induction of apoptosis, inhibition of cell proliferation, modulation of oxidative stress, and anti‐inflammatory activities. Studies have demonstrated that RES can significantly enhance the effectiveness of traditional chemotherapeutic agents, such as 5‐fluorouracil (5‐FU), by inhibiting cellular proliferation and inducing apoptosis in cancerous cells. Furthermore, resveratrol's antioxidant properties may mitigate the impact of reactive oxygen species (ROS) triggered by UV exposure, thus reducing DNA damage and mutations associated with skin cancer development. In vitro and in vivo experiments have shown that RES can effectively hinder the growth and spread of various tumor cell types, including human cutaneous SCC A431 cells, and induce apoptosis. The development of advanced delivery systems, such as nanostructured lipid carriers and liposomes, has been recognized for their potential to enhance the therapeutic effects of RES, particularly its anticancer properties. In conclusion, RES presents a viable candidate for the prevention and treatment of NMSC, owing to its multifaceted mechanisms of action, including its ability to regulate oxidative stress, trigger apoptosis, and inhibit proliferation. However, further clinical studies are required to fully understand its effectiveness and safety in humans, as well as to optimize delivery methods for improved bioavailability and therapeutic outcomes.

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Role of non-coding RNAs in the progression and resistance of cutaneous malignancies and autoimmune diseases

Cited by 25 publications

References 266 publications

Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine

Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine

Integrative Analysis of CircRNA Expression and Associated ceRNA Network in Graves’ Disease

Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review

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