Role of noncoding RNA in vascular remodelling

Lin, Dehui; Bradshaw, Angela C.; Baker, Andrew H.

doi:10.1097/mol.0000000000000336

Cited by 34 publications

(24 citation statements)

References 113 publications

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“…LncRNAs are emerging as regulators of vascular function in health and disease. It is increasingly important to rapidly identify LncRNAs that are implicated in vascular disease [7]. LncRNAs can also regulate redox state in vivo .…”

Section: Introductionmentioning

confidence: 99%

Impact of exudative diathesis induced by selenium deficiency on LncRNAs and their roles in the oxidative reduction process in broiler chick veins

et al. 2017

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Selenium deficiency may induce exudative diathesis (ED) in broiler chick, and this damage is closely related to oxidative damage. Long noncoding RNA (LncRNA) can regulate the redox state in vivo. The aim of the present study was to clarify the LncRNA expression profile in broiler veins and filter and verify the LncRNAs related to oxidative damage of ED. This study established an ED model induced by selenium deficiency and presented the expression and characterization of LncRNAs in normal and ED samples. A total of 15412 LncRNAs (including 8052 novel LncRNAs) were generated in six cDNA libraries using the Illumina Hi-Seq 4000 platform. 635 distinct changes in LncRNAs (up-regulated fold change > 1.5, down-regulated fold change < 0.67 and differentially expressed LncRNAs) were filtered. Gene ontology enrichment on LncRNAs target genes showed that the oxidative reduction process was important. This study also defined and verified 19 target mRNAs of 23 LncRNAs related to the oxidative reduction process. The in vivo and vitro experiments also demonstrated these 23 LncRNAs can participate in the oxidative reduction process. This study presents LncRNAs expression profile in broiler chick veins for the first time and confirmed 23 LncRNAs involving in the vein oxidative damage in ED.

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Section: Introductionmentioning

confidence: 99%

Impact of exudative diathesis induced by selenium deficiency on LncRNAs and their roles in the oxidative reduction process in broiler chick veins

et al. 2017

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“…It has been shown that aberrant lncRNAs expression can result in dysregulation of downstream effector molecules and consequently lead to the pathogenesis of CVD. Recent studies also showed that lncRNAs were pivotal regulators of VSMCs and ECs proliferation, migration, and cell motility . As atherosclerosis is mostly characterized by vascular dysfunction, it is plausible that lncRNAs are potential regulators of atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

LncRNA‐RP11‐714G18.1 suppresses vascular cell migration via directly targeting LRP2BP

Zhang

Zheng

et al. 2017

Immunol Cell Biol

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Atherosclerotic cardiovascular disease is considered as the leading cause of mortality and morbidity worldwide. Accumulating evidence supports an important role for long noncoding RNA (lncRNA) in the pathogenesis of atherosclerosis. Nevertheless, the role of lncRNA in atherosclerosis-associated vascular dysfunction and the underlying mechanism remain elusive. Here, using microarray analysis, we identified a novel lncRNA RP11-714G18.1 with significant reduced expression in human advanced atherosclerotic plaque tissues. We demonstrated in both human vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) that RP11-714G18.1 impaired cell migration, reduced the adhesion of ECs to monocytes, suppressed the neoangiogenesis, decreased apoptosis of VSMCs and promoted nitric oxide production. Mechanistically, RP11-714G18.1 could directly bind to its nearby gene LRP2BP and increased the expression of LRP2BP. Moreover, we showed that RP11-714G18.1 impaired cell migration through LRP2BP-mediated downregulation of matrix metalloproteinase (MMP)1 in both ECs and VSMCs. In atherosclerotic patients, the serum levels of LRP2BP were positively correlated with high-density lipoprotein cholesterol, but negatively correlated with cardiac troponin I. Our study suggests that RP11-714G18.1 may play an athero-protective role by inhibiting vascular cell migration via RP11-714G18.1/LRP2BP/MMP1 signaling pathway, and targeting the pathway may provide new therapeutic approaches for atherosclerosis.

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“…Noncoding RNAs (ncRNAs), including ribosomal RNAs, transfer RNAs, small nuclear RNAs, small nucleolar RNAs, P-element induced wimpy testis interacting RNAs, microRNAs, and long ncRNAs, do not encode proteins. Some ncRNAs play critical regulatory roles in vascular physiology (3)(4)(5). Among them, circular RNAs (circRNAs) have been studied more intensively in recent years.…”

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confidence: 99%

circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

Chang

Rong

et al. 2018

FASEB j.

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Intimal hyperplasia is a reaction to vascular injury, which is the primary reason for vascular restenosis caused by the diagnostic or therapeutic procedure for cardiovascular diseases. Circular RNAs (circRNAs) are known to be associated with several cardiovascular conditions, but the expression of circRNAs in the neointima has not been reported in detail. In this study, we established the balloon‐injured rat carotid artery model and detected the expression of circRNAs in the carotid arteries with a microarray. We found that the circRNA expression profile of the healthy carotid arteries and the injured arteries were significantly different. We investigated the role of rno‐circ_005717 (circDiaph3) in the differentiation of rat vascular smooth muscle cells (VSMCs). We found that knockdown of circDiaph3 up‐regulated the level of diaphanous‐related formin‐3 and promoted the differentiation of VSMCs to contractile type. In addition, circDiaph3 up‐regulated the transcription of Igf1r and supported the proliferation and migration of VSMCs. circDiaph3 could be a molecular target to combat intimal hyperplasia.—Xu, J.‐Y., Chang, N.‐B., Rong, Z.‐H., Li, T., Xiao, L., Yao, Q.‐P., Jiang, R., Jiang, J. circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration. FASEB J. 33, 2659–2668 (2019). http://www.fasebj.org

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Role of noncoding RNA in vascular remodelling

Cited by 34 publications

References 113 publications

Impact of exudative diathesis induced by selenium deficiency on LncRNAs and their roles in the oxidative reduction process in broiler chick veins

Impact of exudative diathesis induced by selenium deficiency on LncRNAs and their roles in the oxidative reduction process in broiler chick veins

LncRNA‐RP11‐714G18.1 suppresses vascular cell migration via directly targeting LRP2BP

circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

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