1974
DOI: 10.1021/jf60193a055
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Role of nonoxidative metabolism in organophosphorus resistance

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Cited by 61 publications
(14 citation statements)
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“…The expression of the known esterase B gene, CpipJ CPIJ013917, increased 16-fold in the resistant strain, while the esterase A gene, CpipJ CPIJ013918, did not show differential expression between the two strains. Three Epsilon GSTs had prominent involvement in resistance, as previously reported in DDT- and OP-resistant mosquitoes and houseflies [22,23]. Seven P450 genes with elevated expression in the resistant strain belonged to either the CYP9 or CYP6 groups, which are usually implicated in pyrethroid resistance in mosquitoes and other species [18].…”
Section: Resultsmentioning
confidence: 67%
“…The expression of the known esterase B gene, CpipJ CPIJ013917, increased 16-fold in the resistant strain, while the esterase A gene, CpipJ CPIJ013918, did not show differential expression between the two strains. Three Epsilon GSTs had prominent involvement in resistance, as previously reported in DDT- and OP-resistant mosquitoes and houseflies [22,23]. Seven P450 genes with elevated expression in the resistant strain belonged to either the CYP9 or CYP6 groups, which are usually implicated in pyrethroid resistance in mosquitoes and other species [18].…”
Section: Resultsmentioning
confidence: 67%
“…aegypti has identified two enzyme families as candidates for conferring insecticide resistance in this species. CYP9 P450s have been implicated in pyrethroid resistance in other species (Pittendrigh et al, 1997) and elevated expression of Epsilon GSTs have been shown to cause DDT and OP resistance in mosquitoes and houseflies (Motoyama and Dauterman, 1974;Ranson et al, 2001) although the role of GSTs in pyrethroid metabolism is less clear and clearly warrants further investigation. Further experiments with additional resistant populations will help refine this candidate gene list.…”
Section: Discussionmentioning
confidence: 99%
“…Motoyama and Dauterman (1974) reported that phosphatases can hydrolyse organophosphorus insecticides by clearing off the leaving groups and result in nontoxic dialkyl phosphorothioic acid or phosphoric acid. Ishaaya et al (1983) reported that the susceptibility of S. littoralis larvae to pyrethroids appeared to be limited by pyrethroid esterases in the gut.…”
Section: Discussionmentioning
confidence: 99%