Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study

Coradduzza, Donatella; Ghironi, Adriana; Azara, Emanuela; Culeddu, Nicola; Cruciani, Sara; Zinellu, Angelo; Maioli, Margherita; Miglio, Maria Rosaria De; Medici, Serenella; Fozza, Claudio; Carru, Ciriaco

doi:10.3390/diagnostics12092151

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…Among transcriptional target of p53 some are involved in polyamine catabolism, molecules known to be involved in tumorgenesis. Activation of the expression of spermidine/spermine N1-acetyltransferase 1 (SAT1), through lipid peroxidation is involved in sensitisation of cells to ferroptosis [ 64 , 65 , 66 , 67 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Ferroptosis and Senescence: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

IJMS

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Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decay in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essential role in the aging process and significantly contributes to the development of age-related complications. On the other hand, ferroptosis is a systemic cell death pathway characterized by excessive iron accumulation followed by the generation of reactive oxygen species (ROS). Oxidative stress is a common trigger of this condition and may be induced by various factors such as toxins, drugs, and inflammation. Ferroptosis is linked to numerous disorders, including cardiovascular disease, neurodegeneration, and cancer. Senescence is believed to contribute to the decay in tissue and organ functions occurring with aging. It has also been linked to the development of age-related pathologies, such as cardiovascular diseases, diabetes, and cancer. In particular, senescent cells have been shown to produce inflammatory cytokines and other pro-inflammatory molecules that can contribute to these conditions. In turn, ferroptosis has been linked to the development of various health disorders, including neurodegeneration, cardiovascular disease, and cancer. Ferroptosis is known to play a role in the development of these pathologies by promoting the death of damaged or diseased cells and contributing to the inflammation often associated. Both senescence and ferroptosis are complex pathways that are still not fully understood. Further research is needed to thoroughly investigate the role of these processes in aging and disease, and to identify potential interventions to target such processes in order to prevent or treat age-related conditions. This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, ferroptosis, aging, and disease, and whether they can be exploited to block or limit the decay of the physiological functions in elderly people for a healthy longevity.

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Section: Resultsmentioning

confidence: 99%

Ferroptosis and Senescence: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

IJMS

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“…However, an opposite trend was described by Jemimah et al in a similar meta-analysis, reporting an insignificant but moderate increase in the Firmicutes phylum and a moderate decrease in the Bacteroidetes phylum in individuals with Alzheimer’s disease or mild cognitive impairment [ 79 ]. Nevertheless, both Vogt et al and Jemimah et al described higher amounts of the genus Bilophila of the phylum Proteobacteria in individuals with Alzheimer’s disease [ 36 , 41 , 79 ]. Furthermore, at the genus level, Ruminococcus , Bilophila , Desulfovibrio , Barnesiella , Butyricimonas , Acidaminococcus , Pyramidobacter , and Oxalobacter were negatively associated with measures of cognition function [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

“…The gut microbiota plays a critical intrinsic role in the communication between an individual’s gut and brain, enabling it to influence the brain and trigger the production of neurotransmitters and neurotrophins [ 33 ]. As a result, the gut microbiome can modulate several inflammatory processes within the human body amongst other important mechanisms [ 34 , 35 , 36 , 37 ]. As depicted by Komanduri et al, “this close mutualistic relationship between the bacteria and the host indicates an important role of bacteria in biological and psychological features of the host” [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis

Coradduzza,

Sedda,

Cruciani

et al. 2023

IJMS

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Aging is a complex process influenced by genetics and the environment, leading to physiological decline and increased susceptibility to diseases. Cognitive decline is a prominent feature of aging, with implications for different neurodegenerative disorders. The gut microbiome has gained attention for its potential impact on health and disease, including cognitive function. This systematic review and meta-analysis aimed to investigate the relationship between the gut microbiome and cognitive function in the context of aging. Following PRISMA guidelines, a comprehensive search strategy was employed in PubMed, Scopus, and Web of Science databases. Studies exploring the role of the microbiome in cognition and neurodegenerative disorders, published between 2013 and 2023, were included. Data extraction and quality assessment were performed. Quantitative synthesis using statistical analyses was performed to examine microbial diversity and relative abundance in various cognitive conditions. Sixteen studies involving a total of 1303 participants were included in the analysis. The gut microbiota’s relative abundance was different in individuals with cognitive impairments such as Alzheimer’s disease, Parkinson’s disease, and dementia, compared to the healthy controls. The most prevalent phyla affected were Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria. Meta-analyses indicated substantial heterogeneity among studies focusing on Alzheimer’s disease. The overall quality of evidence related to microbial analysis was moderate. The gut microbiome’s role in cognitive decline and neurodegenerative disorders warrants investigation. Altered microbial abundance, particularly in specific phyla, is associated with cognitive impairments. However, variations in study findings and methodologies highlight the complexity of the relationship between the gut microbiome and cognitive function. Further studies are needed to better understand the mechanisms underlying this connection and its potential implications for aging and cognitive health.

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“…Many strategies, such as the study of ferroptosis [ 6 ], have evaluated suppression of ROS generation as a potential strategy against senescence. Among the molecules counteracting oxidative stress, polyamines, whose regulation is over-regulated by the ODC gene transcription, have also emerged and play multiple roles [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

Biology

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Background: Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. These conditions play an essential role in aging and significantly contribute to the development of age-related complications. Humanin is a mitochondrial-derived peptide (MDP), encoded by mitochondrial DNA, playing a cytoprotective role to preserve mitochondrial function and cell viability under stressful and senescence conditions. For these reasons, humanin can be exploited in strategies aiming to counteract several processes involved in aging, including cardiovascular disease, neurodegeneration, and cancer. Relevance of these conditions to aging and disease: Senescence appears to be involved in the decay in organ and tissue function, it has also been related to the development of age-related diseases, such as cardiovascular conditions, cancer, and diabetes. In particular, senescent cells produce inflammatory cytokines and other pro-inflammatory molecules that can participate to the development of such diseases. Humanin, on the other hand, seems to contrast the development of such conditions, and it is also known to play a role in these diseases by promoting the death of damaged or malfunctioning cells and contributing to the inflammation often associated with them. Both senescence and humanin-related mechanisms are complex processes that have not been fully clarified yet. Further research is needed to thoroughly understand the role of such processes in aging and disease and identify potential interventions to target them in order to prevent or treat age-related conditions. Objectives: This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, humanin, aging, and disease.

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Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study

Cited by 11 publications

References 38 publications

Ferroptosis and Senescence: A Systematic Review

Ferroptosis and Senescence: A Systematic Review

Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

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