Role of prophylactic use of tranexamic acid in reducing blood loss during caesarean section in a tertiary care hospital

Abstract

Postpartum Haemorrhage (PPH) is an important cause of maternal death and severe maternal morbidity. Compared to vaginal delivery, women undergoing caesarean delivery incur the highest risk of PPH and haemorrhage related morbidity. Furthermore, evidence suggests that PPH during caesarean delivery is occurring more frequently. To study the effect of low dose intravenous tranexamic acid in reducing blood loss during Caesarean section.: This randomized control trial among 50 antenatal women aged >18 years undergoing Lower segment caesarean section in tertiary care centre. They were divided into Study group and control group. Study group received 1gm iv tranexamic acid and the Control group did not receive tranexamic acid. Data was entered in Microsoft Excel data sheet (MS-Excel) and analysed using commercially available SPSS 23 software package. MS Excel and MS word was used to obtain various types of graphs such as bar diagram. : Among the study population who underwent Lower section caesarean section in our study, we found that the requirement of additional oxytocin was nil with tranexamic acid group (p value<0.02). There were no side effects observed with the group administered tranexamic acid (p value<0.01). The difference in mean of bleeding from placental delivery to end of Caesarean Section, End of Caesarean Section to 2 hrs Postpartum was statistically significant (p value <0.05). The fall in Hb% between the two groups was significant, thereby showing the benefits of Tranexamic acid.: Tranexamic acid significantly reduces the amount of blood loss during and after lower segment caesarean section. It was not associated with any significant side effects and complications. It can be used effectively in all women undergoing caesarean section to reduce the postpartum Haemorrhage thereby reducing the maternal morbidity and mortality.