Nowadays the problem of plaque-induced gingivitis, including in the different periods of childhood, is marked by a considerable long-term sociomedical impact on individual, group, population and community levels globally. The purpose of this investigation is to study, analyze and summarize various scientific sources on the role and significance of some salivary amino acids in the presence of periodontal diseases, including plaque-induced gingivitis. This manuscript is based on data obtained from research articles, randomized trials, and systemic reviews published in PubMed and Google Scholar. Different salivary markers are characterized by potential for earlier diagnosis of the progression of oral diseases. We can conclude that some salivary amino acids play a considerable role in the periodontal status, including in plaque-induced gingivitis.