Role of sebaceous glands in inflammatory dermatoses

Shi, Vivian Y.; Leo, Michael S; Hassoun, Lauren A.; Chahal, Dev S.; Maibach, Howard I.; Sivamani, Raja K

doi:10.1016/j.jaad.2015.08.015

Cited by 120 publications

(119 citation statements)

References 84 publications

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“…Sebaceous glands contribute to skin barrier function and their alteration may play a role in the pathogenesis of seborrheic dermatitis and other common skin diseases such as acne vulgaris, atopic dermatitis, psoriasis, and rosacea [30]. There is a significant increase in the levels of the biological markers cathepsin S, proteinase-activated receptor 2 and histamine patients with seborrheic dermatitis which correlate with clinical parameters [31].…”

Section: Pathogenesis Of Seborrheic Dermatitismentioning

confidence: 99%

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Argirov¹,

Bakardzhiev²

2017

CRDOA

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Seborrheic dermatitis represents a chronic, widespread skin disease that is considered a multifactorial disorder influenced, in part, by Malassezia spp.opportunistic activities as well as by various endogenous and exogenous factors. This review systematizes the recent scientific achievements in the field of insufficiently elucidated etiology and pathogenesis of seborrheic dermatitis. IntroductionSeborrheic dermatitis is initially described by P. G. Unna in 1887 and the association with Malassezia yeasts is accepted up to the middle of the 20th century, when the observed increased epidermal cell turnover gradually prompts researchers to characterize this condition as being intrinsic to the skin[1, 2].Seborrheic dermatitis is common dermatological problem that affects the seborrheic areas of the body. It is considered the same basic condition like dandruff sharing many features and responding to similar treatments, differing only in locality and severity. Current use of varying terms for seborrheic dermatitis such as sebopsoriasis, seborrheic eczema, dandruff, and pityriasis capitis reflects the complex nature of this common skin pathology [3]. Much controversy remains regarding the pathogenesis of seborrheic dermatitis and its classification in the spectrum of cutaneous diseases as a form of dermatitis, a fungal disease, or an inflammatory disease, closely related with psoriasis.The prevalence of seborrheic dermatitis peaks when sebaceous gland activity is high, during the first three months of life (infantile seborrheic dermatitis), during puberty and when sebum excretion is reduced after the age of 50 years [2]. Because of smaller sebum production, seborrheic dermatitis flares occur more often in spring than in summer. Disease flare could be associated with altered population dynamics affected not only by variations in sebaceous gland activity but also by modifications in other nutrients supplied by sweat, such as essential amino acids like glycine and tryptophan.Glycine stimulates the fast growth of M. furfur and after its exhaustion yeast cells employ tryptophan as a nitrogen source, increasing the production of indolic metabolites [4]. Such cycles of population growth, bioactive indole production, and subsequent deprivation of nutrients result in insufficiently masked antigens and ligands on the surface of the yeast cells leading to immune system activation.Seborrheic dermatitis occurs on the scalp as well as on face, retroauricular area, and the upper chest, causing flaking, scaling, inflammation, pruritus, and, sometimes, marked erythema [5]. Flaking is usually white-to-yellowish, and may be oily or dry. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors play a pathogenetic role in seborrheic dermatitis. Etiology of Seborrheic DermatitisThere are three principal factors that play a role in the etiology of seborrheic dermatitis [6]: sebaceous gland secretion, alteration in col...

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Section: Pathogenesis Of Seborrheic Dermatitismentioning

confidence: 99%

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Argirov¹,

Bakardzhiev²

2017

CRDOA

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“…A marked reduction of sebaceous lipids, but also a significant increase in keratinocyte lipids, have been demonstrated in pediatric and adult patients with atopic dermatitis correlated with a decrease of sebocyte proliferation and prolongation of the S-phase in SG [26]. Moreover, in acne patients the incidence of constitutional eczema is significant lower than that occurring in the general population [27].…”

Section: Introductionmentioning

confidence: 96%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

118

112

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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“…Acne develops as a result of an interplay of the following factors: follicular epidermal hyperproliferation with hyperkeratosis, excess sebum production, the presence and activity of the commensal bacteria Propionibacterium acnes (P.acnes), androgen excess states, and inflammation. [1,5,6] Previously, it was reported that the release of the cytokine IL-1α by keratinocytes of the sebaceous duct was pivotal in the life cycle of the comedone, mediating both its development and its spontaneous resolution.…”

Section: Introductionmentioning

confidence: 99%

Role of Cytokines in the Pathogenesis of Acne

Демина¹,

Kartelishev²,

Карпова³

et al. 2017

Int J Biomed

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The aim of this study was to investigate the role of cytokines in light of recently discovered aspects of acne immunopathogenesis. Materials and Methods:The study included 276 patients aged between 16 to 44 years with various forms of acne vulgaris. Severe manifestations of the disease were identified in 126/45.6% patients; disease lasted 1 to 5 years in 157/56.9% patients. The serum levels of cytokines were determined by ELISA using standard kits. The cells were characterized using flow cytometry.Results: The obtained data on an excessive secretion of pro-inflammatory cytokines (IL-1α, IL-2) and VEGF on the background of decreasing the content of anti-inflammatory cytokines (IL-4, IL-10) indicate an insufficient activity of antiinflammatory immune response. It was concluded that acne is a model of chronic immunodeficiency inflammatory dermatoses with the activation of innate immunity and the subsequent development of the adaptive T-cell immune response. (Int J Biomed. 2017;7(1):37-40.)

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Role of sebaceous glands in inflammatory dermatoses

Cited by 120 publications

References 84 publications

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

New Insights into the Etiopathogenesis of Seborrheic Dermatitis

Beyond acne: Current aspects of sebaceous gland biology and function

Role of Cytokines in the Pathogenesis of Acne

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