Role of superoxide dismutase in the fallopian tube function: Immunohistochemical assessment of superoxide dismutase in the fallopian tube.

Immunohistochemical localization of CuZn-superoxide dismutase in human uterine cervix and cervical cancer.

“…CuZn-SOD immunoreactivity was more intense in the ciliated epithelial cells of the uterine cervix than in the non-ciliated epithelial cells. This same immunoreactive-pattern has also been demonstrated in bronchiolar (45) and tubal epithelial cells (29). The intensive CuZn-SOD activity may be a general characteristic of ciliated cells (29).…”

“…This same immunoreactive-pattern has also been demonstrated in bronchiolar (45) and tubal epithelial cells (29). The intensive CuZn-SOD activity may be a general characteristic of ciliated cells (29). The mitochondria of ciliated cells appear larger in size (9) than those in nonciliated cells.…”

“…The immunoglobulin fraction was obtained from the antiserum by protein A Sepharose CL-4B (Pharmacia Fine Chemicals, Uppsala, Sweden) chromatography. Specificity of the immunoglobulin fraction was also confirmed by Ouchterlony's method, as we already reported (29). Human Cervical Specimens Surgically removed uterine cervix was obtained from 6 cyclic menstruating patients, aged 40 to 45 years old, with uterine myoma.…”

Immunohistochemical assessment of CuZn-superoxide dismutase in the human genital organs.

“…It has been reported that a low oxygen concentration (5%) was beneficial to embryo development in vitro in many species (44,50,52). Furthermore, SOD activity in the oviduct fluid was significantly higher than that in the serum by ESR assay (33). Intensive immunoreactivity of CuZn-SOD in epithelia of endometrium and Fallopian tube, and sub-and supranuclear vacuoles of endometrial epithelium, suggests that developing embryos in the uterus and oviduct may be protected from superoxide anion radicals in CuZn-SOD-rich environments.…”

“…Recently, using a polyclonal antibody produced against recombinant human CuZn-SOD (r-hSOD), we systematically examined the immunohistochemical distribution of CuZn-SOD in the human female (32,33,42) and male genital organs (34). In this review, we discuss the possible roles of CuZn-SOD in the reproductive organs.…”