Role of the B complex in the genetic control of the Rous sarcoma virus induced tumors in chickens

Abstract

INTRODUCTION REVIEW OF LITERATURE The B system and Histocompatibility The Structure of the MHC Genetics and Control of Lymphoid Leukosis Viruses Mechanisms of resistance Recognition of resistance Role of cell-mediated immunity 13 Inheritance of resistance 14 Selection MATERIALS AND METHODS Genetic Stock Inbred lines Outbred line Heavy breed line 20 Virus strains Wing web inoculation and tumor measurement Chorioallantoic membrane inoculation and observations Terminology 22 Statistical analysis 23 RESULTS AND DISCUSSION Multiple Alleles at a Single Locus Linked to the B Complex 26 Single Versus Multiple Loci Linked to the B Complex Role of B Complex Genotype in Cellular Resistance and Tumor Regression Mechanisms 40 Cellular resistance (tv) loci 40