Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine

Voorde, Johan Van de; Leusen, I

doi:10.1016/0014-2999(83)90056-0

Cited by 243 publications

(77 citation statements)

References 14 publications

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“…L'utilisation d'agonistes ou d'antagonistes des récepteurs H1 et H2 contribue de manière importante aux modifications des mécanismes de défense contre les agents pathogènes. La stimulation des cellules endothéliales vasculaires via les récepteurs H1 conduit à l'augmentation de la perméabilité vasculaire (en particulier dans les veinules postcapillaires) [9] et à la libération de NO (nitric oxide) [10]. Par ailleurs, le SYNTHÈSE REVUES TCTP présentant une forte homologie avec le HRF humain a été identifié chez Plasmodium falciparum [22].…”

Section: Propriétés Biologiques De L'histamine Et De Ses Récepteursunclassified

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

et al. 2009

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Section: Propriétés Biologiques De L'histamine Et De Ses Récepteursunclassified

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

et al. 2009

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“…Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10 …”

mentioning

confidence: 99%

“…It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10 …”

mentioning

confidence: 99%

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Obi¹,

Matsumoto

Nishio

1991

Jpn.J.Pharmacol

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ABSTRACT-Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10-5 M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA2 value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the Hi-receptors in the smooth muscle cells, and that H1-and H2-receptors in the endothelial cells of pigs and H2-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions. Remarkable species differences have been reported concerning the responsiveness of coronary vessels to histamine in vitro. Coronary arteries from monkeys and dogs respond to histamine with relaxations (1, 2), while human, pig and cattle coronary arteries respond with contractions (3-6).It has been postulated that the species difference might depend on the ability of histamine to activate H1-and H2-receptors in vascular smooth muscle and H1-receptors in endothelium, which possibly mediate the release of prostaglandin 12 (7, 8) or endothelium-derived relaxing factors (1,9,10

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“…Additionally, recent work has confirmed that the relaxation of arterial smooth muscle in response to histamine can be mediated through an endothelial cell factor which stimulates smooth muscle cell cGMP (12,16,20). This endothelium-dependent response to histamine appears to involve the H1 receptor (20,25).…”

mentioning

confidence: 90%

Histamine receptor-mediated changes in nuclear chromatin of cultured endothelial and smooth muscle cells.

Blank

Hollis

1986

Acta Histochem. Cytochem

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Role of the endothelium in the vasodilator response of rat thoracic aorta to histamine

Cited by 243 publications

References 14 publications

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

Vasomotor effect of histamine on pig and cattle coronary artery in vitro.

Histamine receptor-mediated changes in nuclear chromatin of cultured endothelial and smooth muscle cells.

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