Role of thyroid on testicular lipids in prepubertal, pubertal and adult rats. I. Hyperthyroidism

Aruldhas, M. M.; Valivullah, H. Mohammed; Govindarajulu, P.

doi:10.1016/0304-4165(86)90040-1

Cited by 14 publications

(8 citation statements)

References 41 publications

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Section: Discussionmentioning

confidence: 97%

“…From the present data, it can be revealed that induction of hyperthyroidism resulted in a significant decrease in LH, FSH and testosterone serum levels after 3 or 8 weeks. It was reported that both in human and experimental animals, hyperthyroidism has been associated with abnormal steroidogenesis and/or modification of hypothalamo-hypophyseal gonadal hormone axis (Aruldhas et al, 1986). Manna et al (2001) reported that long-term treatment with T3 suppressed steroidogenesis and that is most likely due to reduction of cholesterol supply to the mitochondrial inner membrane caused by inhibition of StAR (steroidogenic acute regulatory protein) synthesis.…”

Section: Discussionmentioning

confidence: 99%

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Experimentally induced hyperthyroidism influences oxidant and antioxidant status and impairs male gonadal functions in adult rats

2014

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The objective of the present experiment was to study the effect of hyperthyroidism on male gonadal functions and oxidant/antioxidant biomarkers in testis of adult rats. Induction of hyperthyroidism by L-thyroxine (L-T4, 300 μg kg(-1) body weight) treatment once daily for 3 or 8 weeks caused a decrease in body weight gain as well as in absolute genital sex organs weight. The epididymal sperm counts and their motility were significantly decreased in a time-dependent manner following L-T4 treatment. Significant decline in serum levels of luteinising hormone, follicle stimulating hormone and testosterone along with significant increase in serum estradiol level was observed in hyperthyroid rats compared with euthyroid ones. Significant increase in malondialdehyde and nitric oxide concentration associated with significant decrease in superoxide dismutase and catalase activity was also noticed following hyperthyroidism induction. Both reduced glutathione content and glutathione peroxidase activity were increased in hyperthyroid rats compared with control rats. Marked histopathological alterations were observed in testicular section of hyperthyroid rats. These results provide evidence that hypermetabolic state induced by excess level of thyroid hormones may be a causative factor for the impairment of testicular physiology as a consequence of oxidative stress.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Experimentally induced hyperthyroidism influences oxidant and antioxidant status and impairs male gonadal functions in adult rats

2014

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“…Direct effects of T 4 resulted in minimal oxygen consumption changes in testes when T 4 was present in testicular slice incubations (19). Administration of excess T 4 to mature male rats also resulted in a decrease in total lipids, cholesterol, and phospholipids in testes, and rats rendered thyrotoxic by T 4 administration were shown to synthesize increased amounts of testosterone (18,20). Finally, the effects of T 4 on spermatogenesis are conflicting, but it would appear that T 4 does not exert a direct effect on spermatogenesis in mature rats or rams (21).…”

Section: The Effects Of Thyrotoxicosis and Hypothyroidism On The Malementioning

confidence: 94%

Thyroid Function and Human Reproductive Health

Krassas¹,

2010

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Via its interaction in several pathways, normal thyroid function is important to maintain normal reproduction. In both genders, changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism and were already reported many years ago. Male reproduction is adversely affected by both thyrotoxicosis and hypothyroidism. Erectile abnormalities have been reported. Thyrotoxicosis induces abnormalities in sperm motility, whereas hypothyroidism is associated with abnormalities in sperm morphology; the latter normalize when euthyroidism is reached. In females, thyrotoxicosis and hypothyroidism can cause menstrual disturbances. Thyrotoxicosis is associated mainly with hypomenorrhea and polymenorrhea, whereas hypothyroidism is associated mainly with oligomenorrhea. Thyroid dysfunction has also been linked to reduced fertility. Controlled ovarian hyperstimulation leads to important increases in estradiol, which in turn may have an adverse effect on thyroid hormones and TSH. When autoimmune thyroid disease is present, the impact of controlled ovarian hyperstimulation may become more severe, depending on preexisting thyroid abnormalities. Autoimmune thyroid disease is present in 5-20% of unselected pregnant women. Isolated hypothyroxinemia has been described in approximately 2% of pregnancies, without serum TSH elevation and in the absence of thyroid autoantibodies. Overt hypothyroidism has been associated with increased rates of spontaneous abortion, premature delivery and/or low birth weight, fetal distress in labor, and perhaps gestation-induced hypertension and placental abruption. The links between such obstetrical complications and subclinical hypothyroidism are less evident. Thyrotoxicosis during pregnancy is due to Graves' disease and gestational transient thyrotoxicosis. All antithyroid drugs cross the placenta and may potentially affect fetal thyroid function.

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“…Thyroid hormones have emerged as important regulators of male and female reproduction along with hormones of the hypothalamohypophyseal-gonadal axis (10)(11)(12)(13)(14). Hypothyroidism in early childhood delays sexual maturation (15), whereas severe juvenile hypothyroidism causes a distinct form of isosexual precocity (16).…”

mentioning

confidence: 99%

Mechanism underlying transient gestational-onset hypothyroidism–induced impairment of posttesticular sperm maturation in adult rats

Jaganathan

Sashi

Ganapathy

et al. 2010

Fertility and Sterility

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Role of thyroid on testicular lipids in prepubertal, pubertal and adult rats. I. Hyperthyroidism

Cited by 14 publications

References 41 publications

Experimentally induced hyperthyroidism influences oxidant and antioxidant status and impairs male gonadal functions in adult rats

Experimentally induced hyperthyroidism influences oxidant and antioxidant status and impairs male gonadal functions in adult rats

Thyroid Function and Human Reproductive Health

Mechanism underlying transient gestational-onset hypothyroidism–induced impairment of posttesticular sperm maturation in adult rats

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