Role of topical use of insulin in healing of chronic ulcer

Goenka, Gaurav; Athavale, Virendra S; Nirhale, Dakshayani S; Deshpande, Nitin; Agrawal, Kunal; Calcuttawala, Murtuza

doi:10.4103/0975-2870.140400

Cited by 12 publications

(11 citation statements)

References 1 publication

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“…During angiogenesis it undertakes multiple actions including pericyte mobilization and proliferation, proliferation of smooth muscles, fibroblasts and epithelial cells [99]. Indeed, local injection of insulin into diabetic foot ulcer improved the growth of granulation tissue and topical insulin accelerated wound healing in chronic ulcers [100,101].…”

Section: Cell Growthmentioning

confidence: 99%

Molecular Physiology of Insulin Function

Ibrahim¹

2019

JED

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Insulin is a peptide hormone that is secreted by the pancreatic β-cells and it plays a pivotal role in a number of cellular metabolic processes. Structurally, it consists of two chains that are connected by disulphide bonds. It is secreted from the β-cells upon membrane depolarization and opening of potassium sensitive ATP channels. This process can be initiated by several stimuli especially glucose entry into the cell. Insulin signal transduction starts with binding of the receptor which belongs to the tyrosine kinase family and phosphorylation of Insulin Receptor Substrates. Consequently, two well defined pathways i.e. the phosphoinositide-3-kinase which is involved in carbohydrate, lipid and protein metabolism as well as the MAP-kinase pathway which mediates mitogenesis are established. Insulin enhances glycolysis and glycogenesis while inhibiting gluconeogenesis and glycogenolysis. It also promotes lipogenesis and inhibit lipolysis. These effects are possible because of its ability to activate and deactivate several enzymes and other substrates via phosphorylation. It is also involved in the induction of genes coding for important enzymes in these pathways. The effects of insulin extend to the regulation of vascular structure and function partly through its ability to stimulate nitric oxide production. The aim of this article is to summarize the molecular mechanisms behind the most important insulin functions.

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Section: Cell Growthmentioning

confidence: 99%

Molecular Physiology of Insulin Function

Ibrahim¹

2019

JED

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“…A review of the literature on the subject indicates that insulin affects the regeneration and the reconstruction of damaged skin [13][14][15][16][17]. Goenka et al [13] used an insulin preparation to treat patients with diabetic ulcers.…”

Section: Introductionmentioning

confidence: 99%

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

et al. 2021

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Insulin loaded to the polymer network of hydrogels may affect the speed and the quality of wound healing in diabetic patients. The aim of our research was to develop a formulation of insulin that could be applied to the skin. We chose hydrogels commonly used for pharmaceutical compounding, which can provide a form of therapy available to every patient. We prepared different gel formulations using Carbopol® UltrezTM 10, Carbopol® UltrezTM 30, methyl cellulose, and glycerin ointment. The hormone concentration was 1 mg/g of the hydrogel. We assessed the influence of model hydrogels on the pharmaceutical availability of insulin in vitro, and we examined the rheological and the texture parameters of the prepared formulations. Based on spectroscopic methods, we evaluated the influence of model hydrogels on secondary and tertiary structures of insulin. The analysis of rheograms showed that hydrogels are typical of shear-thinning non-Newtonian thixotropic fluids. Insulin release from the formulations occurs in a prolonged manner, providing a longer duration of action of the hormone. The stability of insulin in hydrogels was confirmed. The presence of model hydrogel carriers affects the secondary and the tertiary structures of insulin. The obtained results indicate that hydrogels are promising carriers in the treatment of diabetic foot ulcers. The most effective treatment can be achieved with a methyl cellulose-based insulin preparation.

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“…Tainted injuries will in general have weighty exudate that should be controlled to forestall maceration of encompassing tissue. There might be extensive scent related with disease that might be undesirable and troubling for the patient and family (Athavale et al, 2014). A dressing must be agreeable and satisfactory for the patient and should help mitigate or at any rate, not decline torment, partic-ularly at dressing changes.…”

Section: Introductionmentioning

confidence: 99%

A comparative study to assess the effectiveness of Topical Insulin Dressing vs Normal Saline Dressing on wound healing of Diabetic Foot Ulcer

David

Rajkumar

2020

ijrps

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Diabetic foot ulcer (diabetic foot ulcer) is an injury entering through the profound vascular and collagenous (dermis) layers of the skin in diabetic patients. Helpless information by walking care and helpless foot care rehearses were distinguish as significant danger factors for foot issues in diabetes. The principle target of the investigation was to survey the effectiveness of topical insulin dressing versus saline dressing and analyze the degree of diabetic injury healing. Quasi-experimental with comparative research design was embraced for the investigation. Convenience sampling technique was utilized to choose 60 examples. Structured interview was used to collect background variable and Wagner diabetic wound assessment scale for assessing diabetic wound. The diabetic wound was dressed with topical insulin dressing and normal saline dressing for 6 days. The calculated paired 't' test value of t = 15.703 was found to be statistically highly significant at p<0.001 level whereas the calculated paired 't' test value of t = 3.247 was found to be statistically highly significant at p<0.01 level. There was significant that the topical insulin dressing is the more effective and improving the level of wound healing than normal saline dressing.

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Role of topical use of insulin in healing of chronic ulcer

Cited by 12 publications

References 1 publication

Molecular Physiology of Insulin Function

Molecular Physiology of Insulin Function

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

A comparative study to assess the effectiveness of Topical Insulin Dressing vs Normal Saline Dressing on wound healing of Diabetic Foot Ulcer

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