Role of Trace Elements in Breast Cancer and Their Characterization Using X-Ray Fluorescence Techniques

Kainth, Harpreet Singh; Khandelwal, D. P.; Singh, Ranjit; Singh, Gurjeet; Puri, S.

doi:10.5772/intechopen.95491

Cited by 3 publications

(2 citation statements)

References 75 publications

(108 reference statements)

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“…Many scientific and therapeutic efforts are underway to identify and combat cancer effectively. For this purpose, some X-ray-based imaging techniques like particle-induced X-ray emission (PIXE), energy-dispersive X-ray spectroscopy (EDX), and X-ray fluorescence microscopy (XRF) were used [3][4][5]. Still, these techniques have low sensitivity and accuracy [6].…”

Section: Introductionmentioning

confidence: 99%

A Review on Laser-Induced Breakdown Spectroscopy in Different Cancers Diagnosis and Classification

et al. 2022

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Due to the new demonstrations of Laser-induced breakdown spectroscopy (LIBS) applicability in a surprisingly wide variety of applications, the use of LIBS as a medical diagnostic tool is steadily gaining momentum. Especially in different cancer diseases, LIBS has the potential to become a fast and valuable analytical tool. We addressed LIBS equipment and quantitative analytical procedures, and signal enhancement techniques for improving element detection. For detailed aspects of applications, we reviewed the recent progress of LIBS in different cancer diseases diagnoses by using different tissues and medical fluid as samples. To fulfill the high demands in the medical industry and overcome the severe tissue sample problem, it is proposed that the chemometric and signal amplification techniques for quantitative analysis should be employed, and robust and effective LIBS devices should be developed. This overview of the different cancers by LIBS is meant to summarize the research performed to date and suggest some suitable advanced chemometrics techniques and effective LIBS devices, if successfully implemented, would be significantly beneficial to the medical field in the future.

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Section: Introductionmentioning

confidence: 99%

A Review on Laser-Induced Breakdown Spectroscopy in Different Cancers Diagnosis and Classification

et al. 2022

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“…Trace elements are essential for the activity of numerous enzymes, and therefore, variations in the serum levels of these biochemical markers may be linked to the pathogenesis of various cancers, including oral cancer (17). Therefore, the role of trace elements has been extensively studied in recent years in various types of cancer, such as breast (18)(19)(20), gastric (21,22), lung (23)(24)(25), oral (17,(26)(27)(28)(29) and pancreatic cancers (30), as well as in liver cirrhosis (30). A number of studies have concluded that trace elements can be used for the early prediction or diagnosis of cancer (17,18,23,(26)(27)(28)(29).…”

Section: Comparative Analysis Of Trace Elements In the Saliva And Ser...mentioning

confidence: 99%

Comparative analysis of trace elements in the saliva and serum of patients with oral submucous fibrosis and squamous cell carcinoma

Kumar,

Kumari,

Ealla

et al. 2024

Mol Clin Oncol

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Of note, one third of oral cancer or oral tissue dysfunction cases are from India, primarily resulting from the consumption of Gutkha, a type of smokeless tobacco prevalent among several Indian populations. Gutkha is a mixture of tobacco, areca nut, slaked lime, catechu, spices, sweeteners and essences. Oral submucous fibrosis (OSMF), which is linked to the consumption of areca nut products and tobacco, is a chronic, precancerous condition of the submucosal tissues. OSMF transforms into oral squamous cell carcinoma (OSCC) at a rate of 7-13%. Gutkha also contains various trace elements, such as copper (Cu), zinc (Zn), selenium (Se) and molybdenum (Mo). Alterations in trace element levels in the body are associated with cancer progression. The present study aimed to determine the levels of serum and salivary trace elements in patients with OSMF and OSCC. A total of 80 patients were selected for the study and were divided into four groups of 20 patients in each (Group A, gutkha intake without OSMF; group B, gutkha intake with OSMF; group C, OSCC; and group D, control). The level of Cu was found to be increased and the levels of Zn, Se and Mo were decreased in the serum of patients with OSMF and OSCC compared with the controls. The salivary levels of these elements were lower compared with those in the serum. Age and sex had no significant effect on the levels of these trace elements. The results of the present study affirm the fact that serum and salivary trace elements are altered in pre-malignant and malignant lesions as the disease progresses. As the composition of saliva often varies, monitoring serum trace element levels as diagnostic and prognostic markers may aid in the early detection of the disease and in the management of the treatment efficacy.

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Quantitative analysis of minor and trace elements in blood serum of dairy cattle (Bos taurus) by WDXRF

et al. 2022

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Assessment of heavy metal content in biological fluids is essential to determine human and animal health as a result of exposure to contaminated environments, food, and water. WDXRF is a non-destructive method that involves no chemical treatments. It is possible to perform fast chemical analysis without producing hazardous waste and uses a small sample volume (± 50 mL), which is useful to veterinary usage. Therefore, the aim of this work was to implement an alternative method for minor and trace elements in blood serum samples of dairy cattle (Bos taurus) using WDXRF. It was implemented for the determination of Al, Cr, Co, Fe, Cu, As, and Hg, and the method was evaluated by comparing WDXRF and ICP-OES results of a set of 14 blood serum samples of dairy cattle using principal component analysis (PCA). Results of WDXRF and ICP-OES were statistically equivalent to all analyzed elements, except for Fe and Al, which were still comparable. WDXRF proved to be a suitable alternative methodology for heavy metal detection in animal blood serum samples due to the low sample volume. The results of this study enable a new and fast method for veterinary internal medicine, which requires a technique that quickly detects animals with a high concentration of toxic elements to assure the correct protocols to prevent the animal's death.

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Role of Trace Elements in Breast Cancer and Their Characterization Using X-Ray Fluorescence Techniques

Cited by 3 publications

References 75 publications

A Review on Laser-Induced Breakdown Spectroscopy in Different Cancers Diagnosis and Classification

A Review on Laser-Induced Breakdown Spectroscopy in Different Cancers Diagnosis and Classification

Comparative analysis of trace elements in the saliva and serum of patients with oral submucous fibrosis and squamous cell carcinoma

Quantitative analysis of minor and trace elements in blood serum of dairy cattle (Bos taurus) by WDXRF

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