Rooibos (Aspalathus linearis) offers cardiac protection against ischaemia/reperfusion in the isolated perfused rat heart

Pantsi, W.G.; Marnewick, Jeanine L.; Esterhuyse, Adriaan J; Rautenbach, Fanie; Rooyen, Jacques Van

doi:10.1016/j.phymed.2011.09.069

Cited by 57 publications

(36 citation statements)

References 50 publications

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“…A study reported the protective effect of rooibos extract against myocardial I/R injury. They showed that the aortic output recovery after reperfusion was improved in hearts isolated from male Wistar rats supplemented with aqueous rooibos extract for 7 weeks when compared to that supplemented with green tea ( Camellia sinensis ) extract [187]. …”

Section: In Vivo Effects Of Polyphenols Against Oxidative Stress-imentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

et al. 2017

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Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the potential anti-oxidative effects of polyphenols to control the cardiotoxicity induced by ROS and RNS stress.

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Section: In Vivo Effects Of Polyphenols Against Oxidative Stress-imentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

et al. 2017

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“…At present, according to the World Health Organization, approximately 80% of the world's population depends on indigenous or traditional medicines for their primary health needs (Pantsi et al, 2011). Red palm oil (RPO) which originated from the tropical area of Africa is natural oil obtained from the fleshy orange-red mesocarp of the fruit of palm tree (Elaeis guineensis).…”

Section: Introductionmentioning

confidence: 99%

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Ayeleso¹,

Oguntibeju²,

Aboua³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Diabetes mellitus characterized by hyperglycaemia could affect sperm quality as a result of increased oxidative stress. This study was performed to investigate the effects of red palm oil (RPO), aqueous rooibos tea extracts (RTE) as well as their combination (RPO + RTE) on sperm motility parameters in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated with red palm oil (2 ml/day) and / or aqueous rooibos tea extract (2%) for 7 weeks. Sperm motility parameters were measured using Computer Assisted Sperm Analyzer (CASA). Results: Hyperglycaemia negatively affected the sperm progressive motility significantly at p<0.05. There was a significant decrease (p<0.05) in sperm linearity (LIN) in the diabetic group when compared with the normal control group. RPO supplemented diabetic rats exhibited increased progressive sperm motility, sperm linearity (LIN) and wobble (WOB). Significant decreases (p<0.05) in straight line velocity (VSL) and average path velocity (VAP) of the sperms were observed in all the diabetic groups when compared to the control group. Significant (p<0.05) elevated levels of WOB and LIN were observed following RTE treatment and co-administration with RPO respectively. Conclusion:The present study suggests that red palm oil and / or rooibos administration exhibited no adverse effects on sperm motility parameters but rather showed some beneficial effects.

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“…Supplementation with rooibos, RPO and/or their combination reversed the reduction in GSH levels and GSH : GSSG ratio, observed in t-BHP-treated rats both in the erythrocytes and liver. Recently, Pantsi et al [36] reported that a fermented rooibos supplementation restored the decrease in GSH levels and GSH : GSSG ratio in the hearts of rats subjected to ischaemia/reperfusion injury. Similarly, Marnewick et al [28] also showed that drinking six cups of rooibos per day for six weeks increased the GSH levels and GSH : GSSG ratio in adults at risk for developing cardiovascular disease, while Awoniyi et al [37] reported that rooibos supplementation in t-BHP-treated rats enhance the epididymal sperm GSH levels.…”

Section: Discussionmentioning

confidence: 99%

“…The antioxidant properties of rooibos have been confirmed both in vitro and in vivo [25][26][27][28]. Rooibos has been shown to be antimutagenic [29,30], cancer modulating [31][32][33], antiinflammatory [34], antidiabetic [35], cardioprotective [36], and modulating oxidative stress [27,28,37].…”

Section: Introductionmentioning

confidence: 91%

Protective Effects of Rooibos (Aspalathus Linearis) and/or Red Palm Oil (Elaeis Guineensis) Supplementation on Tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

Ajuwon

Katengua-Thamahane

Rooyen

et al. 2012

Free Radical Biology and Medicine

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The possible protective effects of an aqueous rooibos extract (Aspalathus linearis), red palm oil (RPO) (Elaeis guineensis), or their combination on tert-butyl-hydroperoxide-(t-BHP-)induced oxidative hepatotoxicity in Wistar rats were investigated. tert-butyl hydroperoxide caused a significant ( < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly ( < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver. This apparent oxidative injury was associated with histopathological changes in liver architecture and elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH). Supplementation with rooibos, RPO, or their combination significantly ( < 0.05) decreased CD and MDA levels in the liver and reduced serum level of ALT, AST, and LDH. Likewise, changes observed in the activities of antioxidant enzymes and impairment in redox status in the erythrocytes and liver were reversed. The observed protective effects when rooibos and RPO were supplemented concomitantly were neither additive nor synergistic. Our results suggested that rooibos and RPO, either supplemented alone or combined, are capable of alleviating t-BHP-induced oxidative hepatotoxicity, and the mechanism of this protection may involve inhibition of lipid peroxidation and modulation of antioxidants enzymes and glutathione status.

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Rooibos (Aspalathus linearis) offers cardiac protection against ischaemia/reperfusion in the isolated perfused rat heart

Cited by 57 publications

References 50 publications

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Effects of red palm oil and rooibos on sperm motility parameters in streptozotocininduced diabetic rats

Protective Effects of Rooibos (Aspalathus Linearis) and/or Red Palm Oil (Elaeis Guineensis) Supplementation on Tert-Butyl Hydroperoxide-Induced Oxidative Hepatotoxicity in Wistar Rats

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