Root Bark Extract of Oroxylum indicum Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation

Menon, Seema; Albaqami, Jawaher; Hamdi, Hamida; Lawrence, Lincy; Divya, Menon Kunnathully; Antony, Liya; Padikkala, José; Mathew, S.; Narayanankutty, Arunaksharan

doi:10.3390/molecules27238459

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…In addition, 6-gingerol can decrease fasting plasma glucose, LDH cholesterol, TG, aspartate aminotransferase, and alanine aminotransferase in a rat model of non-alcoholic fatty liver disease [133]. diseases [136,137,138,139].…”

Section: Naringeninmentioning

confidence: 99%

Antiviral activity of natural substances against main arboviruses DENV, ZIKV and CHIKV: literature review

Silva¹,

Santiago²,

Lopes³

et al. 2023

Cuad. Ed. Desar.

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Arboviruses have caused several epidemics worldwide, resulting in significant global health problems. Dengue virus (DENV), Zika virus (ZIKV), and Chikungunya virus (CHIKV) are endemic arboviruses throughout Brazil and have a significant impact on public health. Major gaps in protection against the most significant emerging arboviruses remain, as no antivirals are currently available, and vaccines are only available in a few countries. A potential source of antiviral compounds can be found in natural products, of which several compounds have been documented to have antiviral activities and are expected to have good efficacy and low side effects. Polyphenols and plant extracts have been studied for their antiviral properties against arboviruses and have shown promising results. Natural products continue to play an essential role in drug production and development. This study evaluated the antiviral potential of natural substances and extracts against DENV, ZIKV, and CHIKV. Original articles published between 2018 and 2022 in Portuguese and English on the antiviral activity of natural substances against arboviruses were reviewed. A total of 70 natural substances were evaluated against DENV, ZIKV, and CHIKV, and the potential antiviral activity against these viruses was analyzed. Some of these substances have shown promise in developing new antiviral compounds. With abundant natural products to screen for new antiviral compounds, they play an important role in developing new antiviral drugs and reducing arbovirus cases.

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Section: Naringeninmentioning

confidence: 99%

Antiviral activity of natural substances against main arboviruses DENV, ZIKV and CHIKV: literature review

Silva¹,

Santiago²,

Lopes³

et al. 2023

Cuad. Ed. Desar.

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Un-avoided polycyclic aromatic hydrocarbons exposure on human and animals: current detoxication strategies and future prospects

Yang,

Niu,

Guo

2024

International Journal of Environmental Health Research

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Oroxylum indicum Vent Root Bark Extract Inhibits the Proliferation of Cancer Cells and Induce Apoptotic Cell Death

et al. 2023

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Oroxylum indicum Vent is a medium-sized deciduous tree that belongs to the family Bignoniaceae. The roots of this tree are used as one of the ten ingredients to prepare the Dasamula formulation in the Ayurvedic system of medicine in India. Although traditional uses are attributed to the medicinal plant, there are limited scientific data on its potential. The present study thus analyzed the cytotoxic and apoptotic potential of the plant against different cancer cells. MTT assay was used to determine cytotoxicity using HeLa, HCT 15, and MDA-MB-231 cells, with the IC50 values, revealed at concentrations of 92.43, 133.0, and 112.84 µg/mL respectively. However, the extract was less toxic to non-cancer cells. HeLa cells further treated with OIM were subjected to flow cytometric analysis for studying the cell cycle stages. When untreated cells at G1 phase were found at a relative percentage of 71.9%, it increased to 79.3 and 86% with OIM treatment at concentrations of 50 and 100 µg/mL; cells in the S phase decreased from 10.3 to 8.2 and 7.5%, concluding the arrest of the cell cycle at G1 phase. With further study of apoptotic morphology with dual acridine orange–ethidium bromide staining and Annexin–Hoechst staining, cells at early and late apoptotic stages were observed with OIM treatment at 100 µg/mL concentration. Although such effects were noticed with OIM treatment, it could not be concluded that the extract had remarkable anti-proliferative effects, since the small changes noticed in cell cycle arrest and apoptotic induction were attained at a high concentration of OIM 100 µg/mL. The biological activities of plants and their extracts are attributed to the presence of multifarious compounds present in them. LC-MS Q-TOF analysis confirmed the presence of biochanin A and baicalein in OIM. HPLC-based quantification of baicalein and chrysin was shown to be 3.36 and 1.11 mg/gram dry weight. To conclude, the above results suggest that the root bark of O. indicum has a broad spectrum of biological activities, including anticancer and apoptotic properties.

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Root Bark Extract of Oroxylum indicum Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation

Cited by 3 publications

References 61 publications

Antiviral activity of natural substances against main arboviruses DENV, ZIKV and CHIKV: literature review

Antiviral activity of natural substances against main arboviruses DENV, ZIKV and CHIKV: literature review

Un-avoided polycyclic aromatic hydrocarbons exposure on human and animals: current detoxication strategies and future prospects

Oroxylum indicum Vent Root Bark Extract Inhibits the Proliferation of Cancer Cells and Induce Apoptotic Cell Death

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