Root Canal Treatment and Apical Periodontitis in a Brazilian Population with Type 1 Diabetes Mellitus: A Cross-sectional Paired Study

Limeira, Francisco Ivison Rodrigues; Arantes, Diandra Costa; Oliveira, Carla de Souza; Melo, Daniela Pita de; Magalhães, Cláudia Silami de; Bento, Patrícia Meira

doi:10.1016/j.joen.2020.02.010

Cited by 16 publications

(33 citation statements)

References 27 publications

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“…The latter can be divided into ulcerative colitis and Crohn′s disease. There are two articles (28.5% of the total articles) on rheumatoid arthritis [ 26 , 27 ] and type I diabetes mellitus [ 28 , 29 ]. Inflammatory bowel disease, on the other hand, is the most studied autoimmune disease with regard to its relationship with pulpal-periapical pathology.…”

Section: Resultsmentioning

confidence: 99%

“…All the articles selected in the qualitative synthesis were divided into two types of studies: five were case-control studies [ 27 , 29 , 30 , 31 , 32 ], and two were cross-sectional studies [ 26 , 28 ]. Therefore, we can affirm that 71.5% of the studies belonged to case-control studies and 28.5% belong to cross-sectional studies ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…From the selected studies, 100% were performed in humans, and a total of 1000 patients were analyzed. The sample size among the studies was highly heterogenous: 231 patients [ 29 ], 220 patients [ 32 ], 162 patients [ 27 ], 150 patients [ 28 ], 108 patients [ 30 ], 96 patients [ 26 ], and 33 patients [ 31 ]. Therefore, the arithmetic mean of patients in the studies is 142.85 patients.…”

Section: Resultsmentioning

confidence: 99%

“…In four of them [ 26 , 27 , 30 , 32 ], half of the patients were in the study group, and the other half were in the control group. In two of the remaining studies, the proportion of patients was 2:1 in favor of the control group in one study, [ 28 ] and 2:1 in favor of the study group in the other [ 29 ]. Finally, in one study [ 31 ], 19 patients with autoimmune disease and 14 without it were assessed ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…All seven studies used radiographic images for the diagnosis of apical periodontitis: five used periapical radiographs [ 26 , 27 , 29 , 31 , 32 ]; four of them used orthopantomography [ 27 , 28 , 30 , 32 ], and one used bitewings [ 29 ]. Only three studies [ 26 , 31 , 32 ] claimed to perform a clinical examination.…”

Section: Resultsmentioning

confidence: 99%

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Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review

Guerrero‐Gironés

Ros-Valverde

Pecci-Lloret

et al. 2021

JCM

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Several studies have linked apical periodontitis and systemic diseases. The aim of this study is to present a systematic review of the available literature investigating whether there is an association between pulpal-periapical pathology and autoimmune disease. The review was conducted following the PRISMA statement. A literature search was performed in five databases. Studies involving patients with pulpal-periapical pathology and autoimmune diseases were included in the review. Based on the PICO model, the research question aimed to assess whether there is an increased risk of developing pulpal-periapical pathology in patients with autoimmune disease. Article selection, data extraction, and quality assessment were performed using an adapted version of the STROBE guidelines. A total of seven studies were included in our review. The types of articles were five case-control and two cross-sectional studies. Periapical pathologies were associated to three autoimmune diseases (diabetes mellitus I, rheumatoid arthritis, and inflammatory bowel disease). Among the included studies, four show a low risk of bias, while three present a moderate risk. There could be an association between apical periodontitis and autoimmune diseases, although most studies report statistically non-significant associations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review

Guerrero‐Gironés

Ros-Valverde

Pecci-Lloret

et al. 2021

JCM

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Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

et al. 2021

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Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to evaluate the interrelationship between systemic and periapical tissues pathological conditions. These studies have shown that systemic changes can boost the pathogenesis of endodontic infection, favoring its development and progression. A contrary relationship is reported in numerous studies that affirm the potential of endodontic infection to trigger systemic damage and may lead to the worsening of pre-existing pathologies. Recently, the potential of filling materials to develop systemic changes such as neurological alterations had been evaluated, also showing that systemic diseases can negatively influence tissue responses to filling materials after endodontic treatment. Despite advances in endodontic medicine studies, there are still gaps in knowledge on the mechanisms of interactions between apical periodontitis (AP) and systemic diseases and much research to be done. In this sense, this critical narrative literature review aimed to show the evolution of studies in endodontic medicine to help the endodontist to know the role of systemic diseases in the pathogenesis of AP and the possible interference in the repair of periapical tissues after endodontic treatment, as well as to evidence the systemic complications that can be triggered or aggravated in the presence of endodontic infection.

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Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases

Chung,

Lee,

Chien

et al. 2024

Journal of Dental Sciences

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Root Canal Treatment and Apical Periodontitis in a Brazilian Population with Type 1 Diabetes Mellitus: A Cross-sectional Paired Study

Cited by 16 publications

References 27 publications

Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review

Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review

Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases

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