Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway

Tuohongerbieke, Amanguli; Liu, Liu; Li, Jun; Xin, Xuelei; Aisa, Haji Akber

doi:10.1016/j.bioorg.2023.106348

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…SIRT1 overexpression also fosters insulin signaling by impairing PTP1B, a major inhibitor of insulin receptor (Sun et al 2007 ; Lu et al 2023a ; Wu et al 2023 ). In response to PTP1B inhibition, IGF1 binds to its corresponding receptor and triggers downstream neuroprotective signaling pathways of PI3K/AKT (Yang et al 2018 ; Li et al 2023a ; Tuohongerbieke et al 2023 ). α-Syn aggregation in PD could be suppressed via augmenting SIRT1 and IGF1 activities (Kakoty et al 2023 ).…”

Section: Discussionmentioning

confidence: 99%

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

et al. 2023

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Parkinson’s disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT signaling activation in the treatment of neurodegenerative disorders. PI3K/AKT signaling can be activated via cAMP-dependent pathways achieved by phosphodiesterase 4 (PDE4) inhibition. Roflumilast is a well-known PDE4 inhibitor that is currently used in the treatment of chronic obstructive pulmonary disease. Furthermore, roflumilast has been proposed as a favorable candidate for the treatment of neurological disorders. The current study aimed to unravel the neuroprotective role of roflumilast in the rotenone model of PD in rats. Ninety male rats were allocated into six groups as follows: control, rotenone (1.5 mg/kg/48 h, s.c.), L-dopa (22.5 mg/kg, p.o), and roflumilast (0.2, 0.4 or 0.8 mg/kg, p.o). All treatments were administrated for 21 days 1 h after rotenone injection. Rats treated with roflumilast showed an improvement in motor activity and coordination as well as preservation of dopaminergic neurons in the striatum. Moreover, roflumilast increased cAMP level and activated the PI3K/AKT axis via stimulation of CREB/BDNF/TrkB and SIRT1/PTP1B/IGF1 signaling cascades. Roflumilast also caused an upsurge in mTOR and Nrf2, halted GSK-3β and NF-ĸB, and suppressed FoxO1 and caspase-3. Our study revealed that roflumilast exerted neuroprotective effects in rotenone-induced neurotoxicity in rats. These neuroprotective effects were mediated via the crosstalk between CREB/BDNF/TrkB and SIRT1/PTP1B/IGF1 signaling pathways which activates PI3K/AKT trajectory. Therefore, PDE4 inhibition is likely to offer a reliable persuasive avenue in curing PD via PI3K/AKT signaling activation. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

et al. 2023

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Isolation of Novel Compounds from Lepidium sativum Seeds and Evaluation of Their Potential Anti‐Tumor Activity

Shybyray,

Kaiyrkulova,

Zhao

et al. 2024

Chemistry & Biodiversity

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Four undescribed compounds including a pair of enantiomers of a dihydroarylnaphthalene lignan [(±)‐1], an arylnaphthalene lignan (2), and an indoleacetic acid ester (3), together with four known compounds (4－7), were isolated from the seeds of Lepidium sativum. Their structures were identified by HRMS and NMR spectroscopic data, and the absolute configuration of these compounds were assigned by ECD data in combination with quantum chemical calculations. Compound (‐)‐1 had weak inhibitory activity against HeLa cell line with an IC50 value of 60.23 ± 3.51 μM, and compound (+)‐1 presented moderate inhibitory effect against HeLa cell line with an IC50 value of 19.99 ± 1.00 μM (IC50 value of the positive control was 0.40 ±0.02 μM).

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Lignanamides: A comprehensive review of chemical constituents, biological activities, extraction methods and synthetic pathway

Sun,

Tong,

et al. 2024

Food Chemistry

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Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway

Cited by 4 publications

References 33 publications

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

Isolation of Novel Compounds from Lepidium sativum Seeds and Evaluation of Their Potential Anti‐Tumor Activity

Lignanamides: A comprehensive review of chemical constituents, biological activities, extraction methods and synthetic pathway

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