ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

You, Dong Gil; Deepagan, V. G.; Um, Wooram; Jeon, Sangmin; Son, Sejin; Chang, Hyeyoun; Yoon, Hwa In; Cho, Yong Woo; Swierczewska, Maggie; Lee, Seulki; Pomper, Martin G.; Kwon, Ick Chan; Kim, Kwangmeyung; Park, Jae Hyung

doi:10.1038/srep23200

Cited by 276 publications

(157 citation statements)

References 36 publications

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“…14A-C ). 206 The HTiO 2 NPs effectively suppressed the growth of superficial tumours after US treatment with elevated levels of proinflammatory cytokines and intense vascular damages ( Fig. 14D-F ).…”

Section: Diverse Stimulationsmentioning

confidence: 91%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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Section: Diverse Stimulationsmentioning

confidence: 91%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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“…Strikingly, th tumors treated by a combination of TiO 2 NPs and ultrasound irradiation resulted in a significant inhibition of tumor growth compared with the untreated mice. Recently, long-circulating hydrophilized TiO 2 NPs (HTiO 2 NPs) were designed by You et al the authors, The authors demonstrated that, when systemically administered to mice, HTiO 2 NPs can suppress the progression of a deep side located tumor [199]. Moosavi Nejda et al [200] reported that, the increased intensity of US (20, 32, proposed water-dispersed TiO 2 NPs and SDT as a novel cure for malignant gliomas.…”

Section: Clinical Applications Of Nps Assisted Ultrasound In Cancer Tmentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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“…In addition, these nanoparticles can cause membrane damage and lipid peroxidation. MSN accumulates in the cell nucleus, leads to DNA damage, and disturbs replication and transcription processes (29). All of these results show that MSN loaded with HpD causes cancer cells death.…”

Section: Discussionmentioning

confidence: 69%

Inhibitory Effects of Silica Nanoparticles Loaded with Hematoporphyrin on Breast Cancer Cell Line

Khaleghian

Hasanzadeh

Moshtaghian

et al. 2018

Middle East J Rehabil Health Stud

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Background: Cancer is one of the main causes of death in the world. In recent years, many studies have been conducted on the usage of nanomaterials in cancer treatment. In previous studies, the anti-tumor effects of mesoporous silica nanoparticles (MSN) on cancer cells have been shown. The aim of this study was to evaluate the effect of MSN loaded with Hematoporphyrin (HpD) on the cell proliferation and invasion of MCF7 (Michigan Cancer Foundation-7) breast cancer cell line. The antioxidant effects of MSN loaded with HpD were also investigated. Methods: In this study, using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, the proliferation and viability of cancer cells were studied after exposure to MSN loaded with HpD. The wound healing assay technique (migration test) was used for the assessment of cancer cells' invasion. The antioxidant effects of MSN loaded with HpD were studied by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and FRAP (ferric reducing/antioxidant power) assay techniques. Results: Our results showed that the viability and proliferation of breast cancer cell line MCF7 in the presence of silica nanoparticles loaded with hematoporphyrin (HpD) significantly declined (P = 0.02). After exposure to mesoporous silica nanoparticles (MSN) loaded with hematoporphyrin (HpD), the cancer cell invasion decreased (P = 0.025). Silica nanoparticles alone and loaded with

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ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

Cited by 276 publications

References 36 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Inhibitory Effects of Silica Nanoparticles Loaded with Hematoporphyrin on Breast Cancer Cell Line

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