ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation

Dang-li, Ren; HeKong, Wang; Liu, Jiqin; Zhang, Minghua; Zhang, Wencheng

doi:10.1007/s11010-011-1013-0

Cited by 40 publications

(20 citation statements)

References 26 publications

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“…[ [135][136][137][138][139][140][141][142][143][144][145][146] VESICULAR TRAFFICKING AND CELL MIGRATION RHOD and RRAS2 are two of most important hub genes of GTPase family. The downexpression of RHOD could impair migration and proliferation of RPE cells.…”

Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning

confidence: 99%

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

et al. 2018

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Retinitis pigmentosa (RP) is a very heterogeneous inherited ocular disorder group characterized by progressive retinal disruption. Retinal pigment epithelium (RPE) degeneration, due to oxidative stress which arrests the metabolic support to photoreceptors, represents one of the principal causes of RP. Here, the role of oxidative stress in RP onset and progression was analyzed by a comparative whole transcriptome analysis of human RPE cells, treated with 100 µg/ml of oxLDL and untreated, at different time points. Experiment was thrice repeated and performed on Ion Proton TM sequencing system. Data analysis, including low quality reads trimming and gene expression quantification, was realized by CLC Genomics Workbench software. The whole analysis highlighted 14 clustered "macro-pathways" and many sub-pathways, classified by selection of 5271 genes showing the highest alteration of expression. Among them, 23 genes were already known to be RP causative ones (15 over-expressed and 8 down-expressed), and their enrichment and intersection analyses highlighted new 77 candidate related genes (49 over-expressed and 28 down-expressed). A final filtering analysis then highlighted 29 proposed candidate genes. This data suggests that many new genes, not yet associated with RP, could influence its etiopathogenesis.

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Section: Retinoic Acid Cycle (Rdh5 Mkv)mentioning

confidence: 99%

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

et al. 2018

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“…LXR/RXR is involved in the regulation of lipid metabolism, inflammation, cholesterol and bile acid catabolism [15]. Acute phase response is a rapid inflammatory response triggered by tissue injury, infection, or immunological disorders [16]. In the process of inflammation, the production of NO pro-inflammatory mediators in macrophages is attributed to the inducible form of nitric oxide synthase (iNOS).…”

Section: Discussionmentioning

confidence: 99%

Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

Zhang²,

et al. 2017

Clin Proteom

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BackgroundThe systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the pathological mechanism and identify novel biomarker and therapeutic target candidates by plasma proteome.MethodsPatients with AICH (n = 8) who demographically matched healthy controls (n = 4) were prospectively enrolled, and their plasma samples were obtained. The TMT-LC–MS/MS-based proteomics approach was used to quantify the differential proteome across plasma samples, and the results were analyzed by Ingenuity Pathway Analysis to explore canonical pathways and the relationship involved in the uploaded data.ResultsCompared with healthy controls, there were 31 differentially expressed proteins in the ICH group (P < 0.05), of which 21 proteins increased while 10 proteins decreased in abundance. These proteins are involved in 21 canonical pathways. One network with high confidence level was selected by the function network analysis, in which 23 proteins, P38MAPK and NFκB signaling pathways participated. Upstream regulator analysis found two regulators, IL6 and TNF, with an activation z-score. Seven biomarker candidates: APCS, FGB, LBP, MGMT, IGFBP2, LYZ, and APOA4 were found. Six candidate proteins were selected to assess the validity of the results by subsequent Western blotting analysis.ConclusionOur analysis provided several intriguing pathways involved in ICH, like LXR/RXR activation, acute phase response signaling, and production of NO and ROS in macrophages pathways. The three upstream regulators: IL-6, TNF, LPS, and seven biomarker candidates: APCS, APOA4, FGB, IGFBP2, LBP, LYZ, and MGMT were uncovered. LPS, APOA4, IGFBP2, LBP, LYZ, and MGMT are novel potential biomarkers in ICH development. The identified proteins and pathways provide new perspectives to the potential pathological mechanism and therapeutic targets underlying ICH.Electronic supplementary materialThe online version of this article (doi:10.1186/s12014-017-9149-x) contains supplementary material, which is available to authorized users.

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“…The chemokine CXCL-8 stimulates the production of eT-1 and plasminogen activation inhibitor 1 (PaI-1) in endothelial cells, disrupting endothelial homeostasis and intensifying pro-coagulant and vasoconstrictive activity, which leads to endothelial dysfunction [48]. Oxidative stress induces the expression of a new transcription factor (ZNf580) and by the Nf-κb signaling pathway stimulates the release of CXCL-8 in the endothelium cells [49]. Nicotinamide adenine dinucleotide phosphate (NadPH) oxidase blockade, one of the main sources of ROS in endothelial cells, inhibits the expression of CXCL-8 through a calcium channel blocker, azelnidipine, and has an antiinflammatory and anti-atherogenic effect [50].…”

Section: Chemokines and Endothelial Dysfunctionmentioning

confidence: 99%

The Role of Chemokines in Hypertension

Martynowicz¹,

Janus²,

Nowacki³

et al. 2014

Adv Clin Exp Med

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Hypertension is a major risk factor for cardiovascular disease, which is a serious health problem in the highly industrialized countries. In more than 95% of the cases, the etiology of hypertension remains unknown. a key role in the etiology of hypertension is played by endothelial dysfunction and the inflammatory reaction in the vascular wall, in which the low molecular weight proteins -so-called chemokines -are involved. The chemokines involved in the pathogenesis of hypertension include monocyte chemoattractant protein-1, MCP-1, CCL2, interferon--inducible protein (IP-10; CXCL10), interleukin-8 (IL-8; CXCL8), RaNTeS (CCL5), fractalkine (CX3CL1) and their receptors CCR2, CCR5, CXCR1, CXCR2, CXCR3 and CX3CR1. The mechanisms involving chemokines and their receptors in the pathogenesis of hypertension are complex and not fully understood. They include the impact of the migration of macrophages and monocytes to the vascular wall, endothelial dysfunction, effects on nitric oxide and endothelin-1 and smooth muscle cell proliferation. Chemokines are also involved in the pathogenesis of complications of hypertension, such as atherosclerosis, myocardial and renal fibrosis. Hypertension is one of the most important risk factors for cardiovascular diseases. In Poland, cardiovascular diseases pose a major medical, economic and social problem. The prevalence of hypertension in Poland reaches 32% of the adult population, but only one in three Poles suffering from hypertension is aware of the disease [1]. In more than 95% of the cases, the etiology of essential hypertension remains unknown. a significant role in the pathogenesis of hypertension is played by genetic factors regulating the transport of ions and water, renal hemodynamics and the function of numerous hormones such as aldosterone, catecholamines, renin, vasopressin and endothelin-1 (eT-1). The level of blood pressure depends on the interplay of numerous systems and factors such as the renin-angiotensin-aldosterone system (RaaS), the sympathetic nervous system, natriuretic peptides and the vascular endothelium. blood pressure level is also affected by factors such as sodium intake, low physical activity, stress and obesity. In recent years, attention has been paid to the participation of inflammatory factors in the etiology of hypertension leading to endothelial dysfunction, which in turn plays a key role in the pathogenesis of hypertension. Low molecular weight proteins of the cytokine family which have the ability to stimulate and control leukocyte migration -so-called chemokines -participate in the inflammatory reaction involving the vascular wall. These proteins have the ability to bind to receptors associated with 7-transdomain G proteins; however, most chemokines bind to more than one receptor, and the receptors are capable of binding more than one * dorian Nowacki's doctoral scholarship is co-financed by the european Union as part of the european Social fund.

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ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation

Cited by 40 publications

References 26 publications

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

RETRACTED ARTICLE: Role of oxidative stress in Retinitis pigmentosa: new involved pathways by an RNA-Seq analysis

Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

The Role of Chemokines in Hypertension

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