ROS-responsive capsules engineered from green tea polyphenol–metal networks for anticancer drug delivery

Wang, Xiaoli; Li, Xuanling; Liang, Xiaoyu; Liang, Jiayi; Zhang, Chao; Yang, Jing; Wang, Chun; Kong, Deling; Sun, Hongfan

doi:10.1039/c7tb02688a

Cited by 67 publications

(48 citation statements)

References 43 publications

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“…ZIF-8 acts as a sacricial template for the formation of the inner cavity of the nanocapsules during the preparation process, and EGCG enables the drug-loaded nanocapsules have a reactive oxygen species (ROS) stimulation response drug release performance. 101 Fang et al coated the Au/polydopamine (Au/ PDA) on the ZIF-8 by in situ polymerization of HAuCl 4 and dopamine, while the template was etched to obtain cubicshaped Au/PDA hybrid microcapsules with adjustable nanostructure. Two different cubic microcapsules, hollow and yolk microcapsules, can be obtained by changing the synthesis kinetics.…”

Section: Synthesis Of Tumor Drug-loaded Nanocapsules By the Zif-8 Sacmentioning

confidence: 99%

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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Section: Synthesis Of Tumor Drug-loaded Nanocapsules By the Zif-8 Sacmentioning

confidence: 99%

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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“…Tea is a pleasant, common, communally accepted, and safe drink that was originally used as a medicine and is now recognized as a significant industrial and pharmaceutical raw material [ 12 ]. Green tea polyphenols (GrTPs), especially epigallocatechin gallate (EGCG), have several beneficial properties, including anti-cancer [ 13 , 14 , 15 ], antioxidant, anti-diabetic, anti-hypertensive, anti-microbial, and anti-metabolic syndrome effects [ 16 ] as well as improving fertility in humans and animals [ 17 ]. Regular consumption of green tea is associated with a decreased risk of ovarian cancer in women [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review

et al. 2018

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Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. In this regard, green tea polyphenols (GrTPs) have been reported to possess properties that may increase the quality of male and female gametes, mostly via the capability of catechins to reduce ROS production. GrTPs have antioxidant properties that improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality. These unique properties of green tea catechins could improve reproductive health and represent an important study area. This exploratory review discusses the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals.

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“…Sun and co‐workers reported polyphenol–metal networks to construct ROS‐responsive capsules that demonstrated the ability to deliver doxorubicin to B16 and BEL‐7402 cells. Jon and co‐workers also reported a drug delivery system responsive to ROS in tumor microenvironments based on biotinylated bilirubin nanoparticles.…”

Section: Ros‐activated Drug Delivery and Small‐molecular Prodrug Systemsmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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ROS-responsive capsules engineered from green tea polyphenol–metal networks for anticancer drug delivery

Abstract: Reactive oxygen species (ROS)-responsive nanocapsules for cancer drug delivery were engineered from green tea polyphenol–metal networks.

Cited by 67 publications

References 43 publications

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

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