Rosacea and Ulcerative Colitis

Walton, Shernaz; Sheth, Mehul K.; Wyatt, E.H.

doi:10.1097/00004836-199010000-00006

Cited by 15 publications

(8 citation statements)

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“…In recent years, an increasing number of studies have suggested a potential relationship between rosacea and gastrointestinal diseases . For example, a recent U.S. cohort study found an increased risk of incident CD, but not UC, in women with rosacea after adjustment for measured confounders, including smoking .…”

Section: Discussionmentioning

confidence: 99%

“…A recent genome‐wide association study (GWAS) identified shared genetic risk loci for rosacea and coeliac disease (CeD), suggesting a pathogenic overlap . Also, cases of fulminant rosacea have been described in patients with inflammatory bowel disease (IBD), including both Crohn disease (CD) and ulcerative colitis (UC) . Moreover, a recent epidemiological study showed a significant association with CD, but not UC, in women with rosacea .…”

mentioning

confidence: 99%

“…6 While a co-occurrence of rosacea and gastrointestinal disorders has previously been evaluated, the topic remains controversial. [7][8][9][10][11][12][13][14] For example, rosacea was significantly associated with small intestinal bacterial overgrowth (SIBO) in 113 patients with rosacea when compared with controls, and another prospective study showed a prevalence of SIBO in 51% of 63 patients with rosacea based on a positive lactulose breath test (LBT). 13,15 However, in a later study of 90 patients with rosacea there was no association with SIBO.…”

mentioning

confidence: 99%

“…17 Also, cases of fulminant rosacea have been described in patients with inflammatory bowel disease (IBD), including both Crohn disease (CD) and ulcerative colitis (UC). 8,9 Moreover, a recent epidemiological study showed a significant association with CD, but not UC, in women with rosacea. [8][9][10][11] To our knowledge, no study has evaluated a possible relationship with irritable bowel syndrome (IBS), but a recent case-control study showed a significant association with various gastrointestinal diseases in a composite end point, which included IBD and IBS.…”

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confidence: 99%

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Rosacea and gastrointestinal disorders: a population‐based cohort study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Rosacea and gastrointestinal disorders: a population‐based cohort study

et al. 2016

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“…Numerous associations have been reported between digestive tract disorders and rosacea. Such diseases include ulcerative colitis, 1 Crohn's disease, 2 gastritis, 3 coeliac disease, 4 hypochlorhydria, 5 abnormalities in jejunal mucosa 4 and Helicobacter pylori infection 6 …”

Section: Reportmentioning

confidence: 99%

Remission of rosacea induced by reduction of gut transit time

Kendall¹

2004

Clin Exp Dermatol

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Rosacea is a chronic disorder characterized by hypersensitivity of the facial vasculature, presenting with intense flushing eventually leading to chronic erythema and telangiectasia. Although the precise aetiology of rosacea is not known, numerous associations with inflammatory gastrointestinal tract disorders have been reported. Furthermore, substance P-immunoreactive neurones occur in considerably greater numbers in tissue surrounding affected blood vessels suggesting involvement of neurogenic inflammation and moreover plasma kallikrein-kinin activation is consistently found in patients. In this report, a patient without digestive tract disease is described, who experienced complete remission of rosacea symptoms following ingestion of a material intended to sweep through the digestive tract and reduce transit time below 30 h. It is possible that intestinal bacteria are capable of plasma kallikrein-kinin activation and that flushing symptoms and the development of other characteristic features of rosacea result from frequent episodes of neurogenic inflammation caused by bradykinin-induced hypersensitization of facial afferent neurones. The possible relevance of this hypothesis to other conditions featuring afferent hypersensitivity, such as fibromyalgia, is considered.

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