“…47 There are several limitations in the current study: (1) lack of dynamic study in the same individuals with different diseases under examination, (2) small number of healthy controls and patients treated with carvedilol, respectively, (3) lack of placebo control group in carvedilol treatment, (4) detection of circulating monocyte subsets and their expression of cell surface marker cannot truly reflect the situ facial conditions, (5) the current classification of clinical subtypes shows varying overlaps and dynamic changes, while PPR alone without ETR remains a debating entity, and PhR is usually accompanied by ETR. 48…”