Rose odor can innately counteract predator odor

Matsukawa, Masakazu; Imada, Masato; Murakami, Toyotaka; Aizawa, Shin; Sato, Takaaki

doi:10.1016/j.brainres.2011.01.053

Cited by 36 publications

(37 citation statements)

References 24 publications

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“…Pleasant olfactory stimuli, such as rose, orange, citrus, lemon and lavender odors, can be experienced as extremely relaxing and calming (Komori et al, 1995a(Komori et al, , 1995bUmezu et al, 2002;Zald, 2003;Almeida et al, 2004;Lehrner et al, 2005;Bradley et al, 2007;Matsukawa et al, 2011). In many countries, aromatherapy is increasingly becoming a beneficial supplement to mainstream treatments for postpartum depression, especially when considering safety of drug treatment (Weier and Beal, 2004;Cavanagh and Wilkinson, 2002).…”

Section: Discussionmentioning

confidence: 98%

Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain

Hui

Liu

et al. 2015

Psychiatry Research

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Olfaction plays an important role in emotions in our daily life. Pleasant odors are known to evoke positive emotions, inducing relaxation and calmness. The beneficial effects of vanillin on depressive model rats were investigated using a combination of behavioral assessments and neurotransmitter measurements. Before and after chronic stress condition (or olfactory bulbectomy), and at the end of vanillin or fluoxetine treatment, body weight, immobility time on the forced swimming test and sucrose consumption in the sucrose consumption test were measured. Changes in these assessments revealed the characteristic phenotypes of depression in rats. Neurotransmitters were measured using ultrahigh-performance liquid chromatography. Our results indicated that vanillin could alleviate depressive symptoms in the rat model of chronic depression via the olfactory pathway. Preliminary analysis of the monoamine neurotransmitters revealed that vanillin elevated both serotonin and dopamine levels in brain tissue. These results provide important mechanistic insights into the protective effect of vanillin against chronic depressive disorder via olfactory pathway. This suggests that vanillin may be a potential pharmacological agent for the treatment of major depressive disorder.

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Section: Discussionmentioning

confidence: 98%

Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain

Hui

Liu

et al. 2015

Psychiatry Research

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“…Future insight into the neural circuits that mediate odor attraction and avoidance may provide insight into the mechanisms and logic underlying these interactions. Interestingly, it has been reported that rose oil and the woody odorant, hinokitiol, can suppress the stress hormone response to TMT (41,42), raising additional questions about the relationship between the ability of odorants to block the behavioral versus stress hormone components of an instinctive fear response.…”

Section: Innate Odor Responses Can Be Modulated By Combinatorial Odorantmentioning

confidence: 99%

Combinatorial effects of odorants on mouse behavior

Saraiva

Kondoh

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The mechanisms by which odors induce instinctive behaviors are largely unknown. Odor detection in the mouse nose is mediated by >1, 000 different odorant receptors (ORs) and trace amine-associated receptors (TAARs). Odor perceptions are encoded combinatorially by ORs and can be altered by slight changes in the combination of activated receptors. However, the stereotyped nature of instinctive odor responses suggests the involvement of specific receptors and genetically programmed neural circuits relatively immune to extraneous odor stimuli and receptor inputs. Here, we report that, contrary to expectation, innate odor-induced behaviors can be context-dependent. First, different ligands for a given TAAR can vary in behavioral effect. Second, when combined, some attractive and aversive odorants neutralize one another's behavioral effects. Both a TAAR ligand and a common odorant block aversion to a predator odor, indicating that this ability is not unique to TAARs and can extend to an aversive response of potential importance to survival. In vitro testing of single receptors with binary odorant mixtures indicates that behavioral blocking can occur without receptor antagonism in the nose. Moreover, genetic ablation of a single receptor prevents its cognate ligand from blocking predator odor aversion, indicating that the blocking requires sensory input from the receptor. Together, these findings indicate that innate odor-induced behaviors can depend on context, that signals from a single receptor can block innate odor aversion, and that instinctive behavioral responses to odors can be modulated by interactions in the brain among signals derived from different receptors.olfaction | behavior | TAAR | odorants

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“…Notably, in insects, input synchronization via inhibition is also important for discrimination of similar odors [41]. Furthermore, mutual inhibition between different odors was previously examined in a mixture of rose and fox-unique TMT odors in mice [42]. A rose-odor-induced decrease was apparent in cells positive for the TMT odor in the aPC vr , and this was accompanied by a subsequent decrease in the TMT-induced stress response.…”

Section: The Second Residue Of Helix 8 Partially Governs the Hieramentioning

confidence: 99%

Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors

Sato

Kawasaki

Mine

et al. 2016

IJMS

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G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G protein activation during neurological, cardiovascular, sensory and reproductive signaling. Common and unique features of interactions between GPCRs and specific G proteins are important for structure-based design of drugs in order to treat GPCR-related diseases. Atomic resolution structures of GPCR complexes with G proteins have revealed shared and extensive interactions between the conserved DRY motif and other residues in transmembrane domains 3 (TM3), 5 and 6, and the target G protein C-terminal region. However, the initial interactions formed between GPCRs and their specific G proteins remain unclear. Alanine scanning mutagenesis of the murine olfactory receptor S6 (mOR-S6) indicated that the N-terminal acidic residue of helix 8 of mOR-S6 is responsible for initial transient and specific interactions with chimeric Gα15_olf, resulting in a response that is 2.2-fold more rapid and 1.7-fold more robust than the interaction with Gα15. Our mutagenesis analysis indicates that the hydrophobic core buried between helix 8 and TM1–2 of mOR-S6 is important for the activation of both Gα15_olf and Gα15. This review focuses on the functional role of the C-terminal amphipathic helix 8 based on several recent GPCR studies.

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Rose odor can innately counteract predator odor

Cited by 36 publications

References 24 publications

Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain

Vanillin-induced amelioration of depression-like behaviors in rats by modulating monoamine neurotransmitters in the brain

Combinatorial effects of odorants on mouse behavior

Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors

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