Rotenone Use in Fish Management and Parkinson's Disease: Another Look

Finlayson, Brian; Schnick, Rosalie A.; Skaar, Don; Anderson, Jonathan D.; DeMong, Leo; Duffield, Dan; Horton, William D.; Steinkjer, Jarle; VanMaaren, Chris

doi:10.1080/03632415.2012.723963

Cited by 10 publications

(15 citation statements)

References 17 publications

(17 reference statements)

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“…156 In humans the greatest risks of exposure to rotenone, 157 considering its commercial applications, include oral, dermal 158 and inhalation routes (Finlayson et al, 2012). Rotenone is 159 hypothesized to have greater toxicity when inhaled rather than 160 ingested due to its small particle size and because the irritation 161 following ingestion often causes prompt vomiting (Hien et Abbreviations: TH, tyrosine hydroxylase; SN, substantia nigra; DA, dopamine; PD, Parkinson's disease.…”

Section: Q3mentioning

confidence: 99%

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

2015

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Section: Q3mentioning

confidence: 99%

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

2015

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“…Rotenone, a naturally-occurring substance derived from the roots of tropical plants, has been used in fisheries for centuries (Finlayson et al, 2012). It has also been used as a broad spectrum of insecticide, piscicide, and pesticide (Dhaouadi et al, 2010, Patel, 2011).…”

Section: Introductionmentioning

confidence: 99%

Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells

Wang

Petucci

et al. 2013

The International Journal of Biochemistry & Cell Biology

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Environmental rotenone is associated with Parkinson’s disease due to its inhibitory property to the complex I of mitochondrial respiration chain. Although environmental pollution has been postulated as a causal factor for the increasing prevalence of obesity, the role of rotenone in the pathogenesis of obesity has not been studied. We employed muscle-derived cell C2C12 as a model and shotgun lipidomics as a tool for lipid analysis and found that treatment of rotenone led to the profound deposition of intracellular triacylglycerol (TAG) in a time- and dose-dependent fashion. The TAG deposition was resulted from complex I inhibition. Further studies revealed that rotenone induced mitochondrial stress including decreased mitochondrial oxygen consumption rate, increased NADH/NAD+ ratio (i.e., reductive stress) and mitochondrial metabolites. We demonstrated that rotenone activated fatty acid de novo synthesis and TAG synthesis and ultimately resulted in intracellular TAG deposition. These studies suggested that increased mitochondrial stresses might be an underlying mechanism responsible for TAG accumulation manifest in obesity.

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“…rainbow trout Oncorhynchus mykiss ) and more tolerant fish species such as carp ( Cyprinus carpio ) and bullheads ( Ameiurus spp.) by Finlayson et al, [ 29 ]. For each taxon, individuals were placed in a glass container filled with 500 ml of each rotenone concentration, receiving no supplementary aeration during the experiment [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

“…For this reason, we assessed the short-term responses of rotenone exposure on selected aquatic invertebrates, using concentrations and exposure durations typically used in river treatments [ 29 , 30 ]. To the best of our knowledge, the effect of rotenone concentration on invertebrate taxa has only been assessed to a small extent (see [ 15 ]) using field application protocol treatments and exposure times in the laboratory.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, the effect of rotenone concentration on invertebrate taxa has only been assessed to a small extent (see [ 15 ]) using field application protocol treatments and exposure times in the laboratory. Our experimental design followed standard piscicide application protocols [ 12 , 15 , 29 , 30 ] and this resulted in a unique opportunity to compare the results from short-term exposure experiments to field observations i.e. the Rondegat River.…”

Section: Introductionmentioning

confidence: 99%

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An Assessment of the Effect of Rotenone on Selected Non-Target Aquatic Fauna

et al. 2015

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Rotenone, a naturally occurring ketone, is widely employed for the management of invasive fish species. The use of rotenone poses serious challenges to conservation practitioners due to its impacts on non-target organisms including amphibians and macroinvertebrates. Using laboratory studies, we investigated the effects of different rotenone concentrations (0, 12.5, 25, 37.5, 50, 100 μg L-1) on selected invertebrate groups; Aeshnidae, Belostomatids, Decapods, Ephemeroptera, Pulmonata and zooplankton over a period of 18 hours. Based on field observations and body size, we hypothesized that Ephemeropterans and zooplankton would be more susceptible to rotenone than Decapods, Belostomatids and snails. Experimental results supported this hypothesis and mortality and behaviour effects varied considerably between taxa, ranging from no effect (crab Potamonuates sidneyi) to 100% mortality (Daphnia pulex and Paradiaptomus lamellatus). Planktonic invertebrates were particularly sensitive to rotenone even at very low concentrations. Future research should investigate the recovery time of invertebrate communities after the application of rotenone and conduct field assessments assessing the longer term effects of rotenone exposure on the population dynamics of those less sensitive organisms.

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Rotenone Use in Fish Management and Parkinson's Disease: Another Look

Cited by 10 publications

References 17 publications

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells

An Assessment of the Effect of Rotenone on Selected Non-Target Aquatic Fauna

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