Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

Chhiber, Nirlep; Kaur, Tarundeep; Singla, Sumit

doi:10.1016/j.phymed.2016.06.005

Cited by 17 publications

(11 citation statements)

References 28 publications

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“…Progressive tissue inflammation together with supersaturation of calcium phosphate then induces Randall's plaque formation and finally kidney stone development (Williams et al, 2016;Patel et al, 2018;Dominguez-Gutierrez et al, 2020). To cope with the impaired immune response and tissue inflammation as well as the interstitial plaque development, various antioxidants or free radical scavengers (Muthukumar and Selvam, 1998;Kohri et al, 2012;Zhai et al, 2013;Aggarwal et al, 2016;Chhiber et al, 2016) and polysaccharide compounds (Veena et al, 2007;Sun et al, 2016;Guo et al, 2018;Sun et al, 2019) have been shown to serve as the therapeutic/preventive strategies to rescue/prevent kidney stone formation.…”

Section: Previous Investigations Of Mitochondria In Kidney Stone Diseasementioning

confidence: 99%

Mitochondrial Dysfunction and Kidney Stone Disease

Chaiyarit

Thongboonkerd

2020

Front. Physiol.

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Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be associated with oxidative stress and tissue inflammation/ injury. Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randall's plaque formation, all of which are the essential mechanisms for kidney stone formation. This review highlights the important roles of mitochondria in renal cell functions and provides the data obtained from previous investigations of mitochondria related to kidney stone disease. In addition, mechanisms for the involvement of mitochondrial dysfunction in the pathophysiology of kidney stone disease are summarized. Finally, future perspectives on the novel approach to prevent kidney stone formation by mitochondrial preservation are discussed.

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Section: Previous Investigations Of Mitochondria In Kidney Stone Diseasementioning

confidence: 99%

Mitochondrial Dysfunction and Kidney Stone Disease

Chaiyarit

Thongboonkerd

2020

Front. Physiol.

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“…The levels of reactive oxygen species (ROS) were not only significantly lowered by 20 μM rottlerin but also inhibited further ROS generation in HCF-7 cell lines (59). The maintenance of anti-oxidant environment by rottlerin may involve the (60). Furthermore, the anti-oxidant activity may also result from increased levels of enzymes such as superoxide dismutase (SOD) and catalase.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…This can be achieved by rottlerin, an active constituent of the plant, which has the ability to quench free radicals. A study conducted on male Wistar rats has shown that rottlerin can potentially prevent stone formation in kidneys probably involving the above mechanism (60).…”

Section: Analgesic Activitymentioning

confidence: 99%

Mallotus philippensis (Lam.) Müll. Arg.: A review on its pharmacology and phytochemistry

Kumar

Patil

Kumar

et al. 2020

J Herbmed Pharmacol

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Kamala tree (Mallotus philippensis) is traditionally used by different ethnic groups to treat a variety of diseases and health ailments. However, these traditional uses need to be scientifically investigated and validated in order to develop drugs from this tree. Therefore, the present article is aimed to review the scientifically validated knowledge on the pharmacology and phytochemistry of the tree. To accomplish this, we extensively surveyed the available databases like Scopus, Web of Science, Google Scholar, ScienceDirect, NCBI including PubMed and PubChem, etc. by using keywords ‘Mallotus philippensis’, ‘Mallotus phillippinensis’ and ‘Mallotus philippinensis’. Our results indicated that the tree possesses more than 50 different types of important phytochemicals of natural origin. The wide array of phytochemicals possesses fascinating biological activities like anthelmintic, antibacterial, anti-inflammatory, anti-oxidant, anti-cancerous, anti-tuberculosis, anti-parasitic, analgesic, anti-urolithiatic and anti-viral activities. Thus, pharmacological activities and isolation of active phytochemicals make the tree a promising candidate for drug discovery. However, pharmacological activities such as antibacterial and anti-oxidant activities are often tested with crude extracts and in vitro rudimentary methods that can be sometimes misleading and non-specific. Thus, more sophisticated techniques may be applied for the isolation of active chemicals and elucidating their mechanism of actions.

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“…Rottlerin [1-(6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl) −3-phenyl-2-propen-1-one] also known as mallotoxin is a natural polyphenol that can be isolated from Mallotus philippinensis [ 156 , 157 ]. Rottlerin might be a potential agent for cancer treatment, e.g., breast cancer [ 158 ].…”

Section: Natural Compounds That Act As Autophagy Inducersmentioning

confidence: 99%

Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing

et al. 2018

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Organismal ageing is associated with increased chance of morbidity or mortality and it is driven by diverse molecular pathways that are affected by both environmental and genetic factors. The progression of ageing correlates with the gradual accumulation of stressors and damaged biomolecules due to the time-dependent decline of stress resistance and functional capacity, which eventually compromise cellular homeodynamics. As protein machines carry out the majority of cellular functions, proteome quality control is critical for cellular functionality and is carried out through the curating activity of the proteostasis network (PN). Key components of the PN are the two main degradation machineries, namely the ubiquitin-proteasome and autophagy-lysosome pathways along with several stress-responsive pathways, such as that of nuclear factor erythroid 2-related factor 2 (Nrf2), which mobilises cytoprotective genomic responses against oxidative and/or xenobiotic damage. Reportedly, genetic or dietary interventions that activate components of the PN delay ageing in evolutionarily diverse organisms. Natural products (extracts or pure compounds) represent an extraordinary inventory of highly diverse structural scaffolds that offer promising activities towards meeting the challenge of increasing healthspan and/or delaying ageing (e.g., spermidine, quercetin or sulforaphane). Herein, we review those natural compounds that have been found to activate proteostatic and/or anti-stress cellular responses and hence have the potential to delay cellular senescence and/or in vivo ageing.

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Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

Cited by 17 publications

References 28 publications

Mitochondrial Dysfunction and Kidney Stone Disease

Mitochondrial Dysfunction and Kidney Stone Disease

Mallotus philippensis (Lam.) Müll. Arg.: A review on its pharmacology and phytochemistry

Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing

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