Routine antenatal molecular testing for α-thalassemia at a tertiary referral hospital in China: ten years of experience
Dongming Li,
Lifang Liang,
Dahua Meng
et al.
Abstract:ObjectiveThis study aimed to evaluate the efficacy of α-thalassemia gene testing as a part of an antenatal intervention program over a 10-year period.MethodsAll patients underwent α-thalassemia gene testing, which included the analysis of three types of deletions and mutations. Rare α-thalassemia gene testing was performed using Sanger sequencing, multiplex ligation-dependent probe amplification, and sequencing techniques. Prenatal diagnosis was performed in high-risk couples using chorionic villus sampling or… Show more
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