Routine screening for colonization by Gram-negative bacteria in neonates at intensive care units for the prediction of sepsis: systematic review and meta-analysis

Seidel, Juliane; Haller, Sebastian; Eckmanns, Tim; Harder, Thomas

doi:10.1016/j.jhin.2018.03.017

Cited by 32 publications

(25 citation statements)

References 22 publications

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“…Furthermore, surveillance and assessment of antibiotic consumption has been demonstrated to positively influence antibiotic stewardship strategy and reduce antibiotic use. [ 77 ] Screening for GNB on neonatal body sites may have a predictive value in neonatal LOS, [ 78 ] and decolonization has been investigated as an approach to prevent sepsis and the spread of multi-resistant GNB. [ 79 ] However, the prognostic value of routine screening of neonatal microbial colonization remains controversial, due to a lack of high-quality evidence, especially in VLBW infants.…”

Section: Empirical Treatment Of Neonatal Sepsismentioning

confidence: 99%

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Neonatal sepsis: within and beyond China

Dong

Basmaci

Titomanlio

et al. 2020

Chinese Medical Journal

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Section: Empirical Treatment Of Neonatal Sepsismentioning

confidence: 99%

“…[ 79 ] However, the prognostic value of routine screening of neonatal microbial colonization remains controversial, due to a lack of high-quality evidence, especially in VLBW infants. [ 31 , 78 ]…”

Section: Empirical Treatment Of Neonatal Sepsismentioning

confidence: 99%

Neonatal sepsis: within and beyond China

Dong

Basmaci

Titomanlio

et al. 2020

Chinese Medical Journal

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“…This potentially useful piece of clinical information is kept with previous findings. In a systematic review and meta-analysis, Seidel et al [21] addressed the prognostic value of routine body surface screening for Gram-negative bacteria in a population of infants up to 12 months admitted to the NICU. Although the study population was very heterogeneous and the global sensitivity was only 41%, the pooled figure for K. pneumoniae was over twofold higher (92%).…”

Section: Discussionmentioning

confidence: 99%

Do isolates from pharyngeal and rectal swabs match blood culture bacterial pathogens in septic VLBW infants? A pilot, cross-sectional study

et al. 2020

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Serial body site swabbing is used to monitor horizontal spread of aggressive bacterial species in the neonatal intensive care unit (NICU). Since colonization/carriage is thought to precede systemic infection, one might expect to retrieve colonizing pathogens from blood cultures. This hypothesis, however, has not been fully investigated in very low birth weight (VLBW) infants that are at high sepsis' risk. The primary outcome was, in a population of VLBW infants with late-onset sepsis, the matching between blood culture results and pathogens isolated from rectal and nose/pharyngeal surveillance swabs in the preceding 2 weeks. The secondary outcomes were the site of swabbing and time interval from colonization to blood culture positivity. Out of 333 VLBW neonates, 80 (24%) were diagnosed with bacterial sepsis. In 46 (57%) neonates, the blood culture showed the same pathogen species cultured from a swab. Of these, 30 were isolated from infants with both body sites colonized with an average time interval of 3.5 days; 2/16 were isolated from rectal swabs and 14 /16 from nose/pharyngeal samples. Conclusion: Our data show a fair correspondence between bacteria colonizing the nasopharynx and/or the rectum and pathogens later isolated from blood cultures. This association depends on the swabbing site, number of sites, and pathogen species. Although these data constitute valuable results, they are not sufficient for providing the sole base of a thoughtful clinical decision.

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“…Die KRINKO empfiehlt aber, im Zusammenhang mit der Känguru-Pflege einige hygienische Grundregeln zu beachten [5] [19,20]. Dennoch sind die Vorteile eines routinemäßigen mikrobiologischen Kolonisationsscreenings umstritten [21].…”

Section: Känguru-pflegeunclassified

Prävention nosokomialer Infektionen in der Neonatologie

Petersen¹,

Piening²

2019

Neonatologie Scan

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Routine screening for colonization by Gram-negative bacteria in neonates at intensive care units for the prediction of sepsis: systematic review and meta-analysis

Cited by 32 publications

References 22 publications

Neonatal sepsis: within and beyond China

Neonatal sepsis: within and beyond China

Do isolates from pharyngeal and rectal swabs match blood culture bacterial pathogens in septic VLBW infants? A pilot, cross-sectional study

Prävention nosokomialer Infektionen in der Neonatologie

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