RP-HPLC method for simultaneous determination of escitalopram oxalate and flupentixol HCl in tablet dosage form

Abstract

RP-HPLC method was developed for simultaneous determination of escitalopram oxalate (ESC) and flupentixol HCl (FLU) in tablet dosage form. Mobile phase consisting of mixture of acetonitrile and potassium phosphate buffer (pH 7.0 with 0.1% triethylamine) in the ratio 60: 40 at flow rate of 1ml/min using C18 Grace (250mmX 4.6mm) column at 231 nm. The retention time of ESC with FLU was found to be 2.96 min and 6.98 min, respectively. The linearity range for ESC with FLU observed was 5-25 µg/ml and 10-50 µg/ml, respectively. Method was validated as per ICH guidelines. Validation parameters studied were linearity and range, recovery study, precision, LOD, LOQ and robustness. Statistical data obtained was found to satisfactorily.

Allium sativum, a potential phytopharmacological source of natural medicine for better health

“…There are various analytical techniques by which active chemical compounds are determined. These methods can also be used for analysis of ACC in pharmaceutical formulations including ayurvedic products [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. In order to justify the writing of Galen from second century "Garlic as the rustic's theriac" means garlic possesses potential to cure all ailments, we searched high quality studies published in renowned journals, reviewed the therapeutic functions of garlic and the bioactive components responsible for it.…”