RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication

Guo, Hongyuan; Zhu, Jie; Miao, Qiuhong; Qi, Ruibin; Tang, Aoxing; Liu, Chuncao; Yang, Hongzao; Yuan, Ligang; Liu, Guangqing

doi:10.1016/j.vetmic.2020.108858

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…2 B–C). It has been demonstrated that RPS5 interacted with the Rabbit hemorrhagic disease virus (RHDV) and played a role in virus replication [ 34 ]. Together, these results suggest that the transcription and translations of several RBPs were perturbed in SARS-CoV-2 infection.…”

Section: Resultsmentioning

confidence: 99%

Multi-omics characterization of RNA binding proteins reveals disease comorbidities and potential drugs in COVID-19

Pan

Gao

Han

et al. 2023

Computers in Biology and Medicine

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Section: Resultsmentioning

confidence: 99%

Multi-omics characterization of RNA binding proteins reveals disease comorbidities and potential drugs in COVID-19

Pan

Gao

Han

et al. 2023

Computers in Biology and Medicine

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“…It was also verified that RPS5 promoted RHDV replication by constructing RPS5 stable overexpression cell lines and RPS5 knockdown cell lines. In summary, it has been identified the focus on the discovery and characterization of disease resistance protein RPS5, and the interaction of RPS5 and RHDV 3′ Ex RNA region, played a role in virus replication [ 67 ]. These data suggest that RPS5 may be a potential target for treating HCV and that the fragment P121-R146 warrants special attention ( Figure 6 ).…”

Section: Rps5 As a Potential Target For Liver Disease And Cancermentioning

confidence: 99%

Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function

Qiu¹,

Chen²,

Zhong³

et al. 2023

IJMS

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The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies on the relationship between the structure and function of prokaryotic RPS7, the structure and molecular details of the mechanism of eukaryotic RPS5 remain largely unexplored. This article focuses on the structure of RPS5 and its role in cells and diseases, especially the binding to 18S rRNA. The role of RPS5 in translation initiation and its potential use as targets for liver disease and cancer are discussed.

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“…By interacting with RPs, the LCMV nucleoprotein (N) can inhibit the antiviral immune response of the host ( Baird et al, 2012 ). Similarly, the 3′-extremity region of rabbit hemorrhagic disease virus (RHDV) interacts with RPS5 to promote replication of viral genes ( Guo et al, 2020 ). Infectious bursal disease virus (IBDV) VP3 protein interacts with RPs to form ribosomal protein assembly complexes to promote viral genome replication ( Ma et al, 2021 ).…”

Section: Ribosomal Proteins Exert Non-ribosomal Functions During Rna ...mentioning

confidence: 99%

Ribosomal control in RNA virus-infected cells

et al. 2022

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Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release. Ribosomes are protein synthesis factories in cells, and viruses need to manipulate ribosomes to complete their protein synthesis. Viruses use translation initiation factors through their own RNA structures or cap structures, thereby inducing ribosomes to synthesize viral proteins. Viruses also affect ribosome production and the assembly of mature ribosomes, and regulate the recognition of mRNA by ribosomes, thereby promoting viral protein synthesis and inhibiting the synthesis of host antiviral immune proteins. Here, we review the remarkable mechanisms used by RNA viruses to regulate ribosomes, in particular, the mechanisms by which RNA viruses induce the formation of specific heterogeneous ribosomes required for viral protein translation. This review provides valuable insights into the control of viral infection and diseases from the perspective of viral protein synthesis.

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RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication

Cited by 4 publications

References 37 publications

Multi-omics characterization of RNA binding proteins reveals disease comorbidities and potential drugs in COVID-19

Multi-omics characterization of RNA binding proteins reveals disease comorbidities and potential drugs in COVID-19

Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function

Ribosomal control in RNA virus-infected cells

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