rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

Xie, Yangli; Guan, Muzhen; Wang, Zhongheng; Ma, Zhengliang; Wang, Huaning; Peng, Fang; Yin, Hong

doi:10.3389/fnins.2021.722894

Cited by 17 publications

(22 citation statements)

References 92 publications

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“…The results regarding alterations in clinical symptoms were fully consistent with the previous report ( 32 ). The results also agree with the meta-analysis studies ( 19 , 20 , 46 ) and confirmed the effectiveness of low-frequency rTMS treatment on AVH in schizophrenia with our previous studies ( 33 , 35 – 37 ). Moreover, rTMS treatment induced beneficial connectivity changes of the seed in the active treatment group, including increased static FC (SFC) with prefrontal regions (e.g., right superior frontal gyrus and right supplementary motor cortex) and decreased SFC with the temporal lobe (e.g., right inferior temporal gyrus and middle temporal gyrus).…”

Section: Discussionsupporting

confidence: 92%

“…Unlike our previous studies using case-control paradigm ( 33 , 35 – 37 ), this study had a single-blind parallel design, only the rTMS administrator rather than researchers or raters knew the conditions to which patients were assigned. Stimulation was performed by a Magstim Rapid System (YIRUDE, Wuhan, China), using a 70 mm figure-of-eight coil.…”

Section: Methodsmentioning

confidence: 99%

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The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment

Xie

Guan²,

Wang³

et al. 2023

Front. Psychiatry

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BackgroundAuditory verbal hallucinations (AVH) are a core symptom of schizophrenia. Low-frequency (e.g., 1 Hz) repetitive transcranial magnetic stimulation (rTMS) targeting language processing regions (e.g., left TPJ) has been evident as a potential treatment for AVH. However, the underlying neural mechanisms of the rTMS treatment effect remain unclear. The present study aimed to investigate the effects of 1 Hz rTMS on functional connectivity (FC) of the temporoparietal junction area (TPJ) seed with the whole brain in schizophrenia patients with AVH.MethodsUsing a single-blind placebo-controlled randomized clinical trial, 55 patients with AVH were randomly divided into active treatment group (n = 30) or placebo group (n = 25). The active treatment group receive 15-day 1 Hz rTMS stimulation to the left TPJ, whereas the placebo group received sham rTMS stimulation to the same site. Resting-state fMRI scans and clinical measures were acquired for all patients before and after treatment. The seed-based (left TPJ) static and DFC was used to assess the connectivity characteristics during rTMS treatment in patients with AVH.ResultsOverall, symptom improvement following 1 Hz rTMS treatment was found in the active treatment group, whereas no change occurred in the placebo group. Moreover, decreased static FC (SFC) of the left TPJ with the right temporal lobes, as well as increased SFC with the prefrontal cortex and subcortical structure were observed in active rTMS group. Increased dynamic FC (DFC) of the left TPJ with frontoparietal areas was also found in the active rTMS group. However, seed-based SFC and DFC were reduced to a great extent in the placebo group. In addition, these changed FC (SFC) strengths in the active rTMS group were associated with reduced severity of clinical outcomes (e.g., positive symptoms).ConclusionThe application of 1 Hz rTMS over the left TPJ may affect connectivity characteristics of the targeted region and contribute to clinical improvement, which shed light on the therapeutic effect of rTMS on schizophrenia with AVH.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment

Xie

Guan²,

Wang³

et al. 2023

Front. Psychiatry

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“…The second peak (ALE value 0.014; p = 0.00001; z = 4.22) was found in the left IFG (MNI coordinates: X = −36, Y = 10, Z = −16, corresponding to BA 13). Notably, the GingerALE report revealed that none of the three studies showing greater grey matter volume in patients compared to controls ( O’Daly et al, 2007 , Shapleske et al, 2002 , Xie et al, 2021 ) contributed.…”

Section: Resultsmentioning

confidence: 97%

“…In particular, we extracted data for 504 patients with SZ and hallucinations, 524 healthy controls and 74 foci (see Table 2 ). Notably, all these studies reported decreased grey matter in patients compared to controls, and only three studies ( O’Daly et al, 2007 , Shapleske et al, 2002 , Xie et al, 2021 ) further showed greater grey matter volume in patients compared to controls. We carried out the main analysis including all these studies, regardless of the direction (decreased or increased) GMV in AVH-SZ patients with respect to healthy controls.…”

Section: Methodsmentioning

confidence: 99%

Hearing voices in the head: Two meta-analyses on structural correlates of auditory hallucinations in schizophrenia

Romeo

Spironelli

2022

NeuroImage: Clinical

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“…High-frequency rTMS can regulate the excitability of the cerebral cortex ( Xie et al, 2021 ). In this study, the left dorsolateral prefrontal cortex was targeted by high-frequency stimulation at 10 HZ, which directly enhanced the neural activity in the target-related brain region ( Du et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder

et al. 2022

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ObjectiveRepetitive transcranial magnetic stimulation (rTMS) can effectively improve depression symptoms in patients with major depressive disorder (MDD); however, its mechanism of action remains obscure. This study explored the neuralimaging mechanisms of rTMS in improving depression symptoms in patients with MDD.MethodsIn this study, MDD patients with first-episode, drug-naive (n = 29) and healthy controls (n = 33) were enrolled. Depression symptoms before and after rTMS treatment were assessed using the Hamilton Depression Rating Scale (HAMD-17). Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected both before and after the treatment. Changes in the brain function after the treatment were compared using the following two indices: the amplitude of the low-frequency fluctuation (ALFF) and regional homogeneity (ReHo), which are sensitive for evaluating spontaneous neuronal activity. The brain region with synchronous changes was selected as the seed point, and the differences in the causal connectivity between the seed point and whole brain before and after rTMS treatment were investigated via Granger causality analysis (GCA).ResultsBefore treatment, patients with MDD had significantly lower ALFF in the left superior frontal gyrus (p < 0.01), higher ALFF in the left middle frontal gyrus and left precuneus (p < 0.01), and lower ReHo in the left middle frontal and left middle occipital gyri (p < 0.01) than the values observed in healthy controls. After the rTMS treatment, the ALFF was significantly increased in the left superior frontal gyrus (p < 0.01) and decreased in the left middle frontal gyrus and left precuneus (p < 0.01). Furthermore, ReHo was significantly increased in the left middle frontal and left middle occipital gyri (p < 0.01) in patients with MDD. Before treatment, GCA using the left middle frontal gyrus (the brain region with synchronous changes) as the seed point revealed a weak bidirectional causal connectivity between the middle and superior frontal gyri as well as a weak causal connectivity from the inferior temporal to the middle frontal gyri. After treatment, these causal connectivities were strengthened. Moreover, the causal connectivity from the inferior temporal gyrus to the middle frontal gyri negatively correlated with the total HAMD-17 score (r = −0.443, p = 0.021).ConclusionrTMS treatment not only improves the local neural activity in the middle frontal gyrus, superior frontal gyrus, and precuneus but also strengthens the bidirectional causal connectivity between the middle and superior frontal gyri and the causal connectivity from the inferior temporal to the middle frontal gyri. Changes in these neuroimaging indices may represent the neural mechanisms underlying rTMS treatment in MDD.Clinical Trial RegistrationThis study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR1800019761).

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rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

Cited by 17 publications

References 92 publications

The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment

The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment

Hearing voices in the head: Two meta-analyses on structural correlates of auditory hallucinations in schizophrenia

Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder

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