Rubella and Deafness

Anomalies of the auditory organ in trisomy 18 syndrome: human temporal bone histopathological study

“…In the present case, many anomalies were found in the middle and inner ear, but no particular changes in the external ear. In one reported case, 3 anomalies were limited to the middle ear, while in another case, 8 anomalies were only found in the inner ear but not in the middle ear. These indicated that many of the ear anomalies in this syndrome might be derived from the component around the rst and second branchial arches.…”

“…Although anomalies of the auditory organ have been noticed in more than 50 per cent of cases, only a few reports have described in detail the histopathological changes in the temporal bone. [2][3][4][5][6][7][8][9] In this FP = footplate of stapes; F = facial nerve; CT = chorda tympani. report, the histopathological ndings of anomalies in the temporal bone of this syndrome are described.…”

“…To date, the histopathological ndings of the temporal bone have been reported in only a few patients with the trisomy 18 syndrome. [2][3][4][5][6][7][8][9] Here we report the temporal bone histopathological ndings in a stillborn fetus with trisomy 18 syndrome, including a three-dimensional reconstruction of the anomalous auditory ossicles.…”