Ruggedness testing and validation of a practical analytical method for &gt;100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography–tandem mass spectrometry

Geis-Asteggiante, Lucía; Lehotay, Steven J.; Dutko, Terry; Ng, Chilton; Bluhm, Louis H.

doi:10.1016/j.chroma.2012.08.020

Cited by 110 publications

(76 citation statements)

References 29 publications

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“…For example, Whelan et al observed that, although ionization could be improved when a lower concentration of additives was present in the mobile phase, ammonium formate increased the sensitivity for some anthelmintics [44]. This was also observed by other authors, who indicated that the use of end-capped C18 and post-column infusion of ammonium formate improved the analytical results for late-eluting anthelmintics [45]. However, for the separation of other types of compounds, such as non-steroidal anti-inflammatory drugs (NSAIDs), because the different pKa values (in the range 3-9.5), acetonitrile and an aqueous solution of formic acid (0.1%) and ammonium acetate (0.5 mM) provided suitable results [46].…”

Section: Veterinary Drugsmentioning

confidence: 62%

“…Although UHPLC can be coupled to QqQ analyzers [50], increasing the number of compounds (~100) [45] and improving the reliability of the confirmation process, in the past few years, UHPLC has also been coupled to HRMS analyzers, such as TOF or Orbitrap (see Table 1). Then, screening and quantification of more than 100 veterinary drugs belonging to several classes can be performed in less than 15 min in milk [23,33], meat [34], or honey, fish, and liver [51].…”

Section: Veterinary Drugsmentioning

confidence: 99%

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Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS

Frenich¹,

Aguilera-Luiz²

2014

TrAC Trends in Analytical Chemistry

117

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Section: Veterinary Drugsmentioning

confidence: 62%

Section: Veterinary Drugsmentioning

confidence: 99%

Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS

Frenich¹,

Aguilera-Luiz²

2014

TrAC Trends in Analytical Chemistry

117

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“…(Bohm et al 2009;Chico et al 2008;Dasenaki and Thomaidis 2015;Freitas et al 2014;Frenich et al 2010;Geis-Asteggiante et al 2012;Granelli and Branzell 2007;Han et al 2015;Hermo et al 2008;Kaufmann et al 2014;Martins-Júnior et al 2007;Mastovska and Lightfield 2008;Ortelli et al 2009;Stolker et al 2008;Turnipseed et al 2014;Wang et al 2015) but there is a lack in the method development for processed dairy products, since antibiotics are not fully degraded during pasteurization process (Pérez et al 2013).…”

Section: Additionally This Technique Fulfills the Requirements Demmentioning

confidence: 99%

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

2017

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In regard to the knowledge of provoking a worldwide resistance against antibiotics due to incorrect application and the resulting uptake of residues via the food chain, the European Union set maximum residue levels (MRLs) for these substances in animal derived products to protect the customers. In respect of these MRLs a multi-class UHPLC-MS/MS multiclass method has been developed for the simultaneous determination of 30 substances from different compound groups (quinolones, macrolides, lincosamides, β-lactams, sulphonamides, diamino-pyrimidine derivates and tetracyclines) in various kinds of dairy products. Since this method should be suitable for routine laboratory use, sample preparation requires an easy and fast approach to ensure high sample throughput. Therefore a sample preparation with C18EC dSPE bulk sorbent as a combination of the easy and quick sample preparation provided by QuEChERS and the clean-up principle of reversed phase SPE was applied. This method was validated for all compounds in all matrices in compliance with the requirements of Commission Decision 2002/657/EC.

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“…While all three sorbent combinations provided satisfactory recoveries, the purification with Z-Sep showed the best values (70-120%) with the maximum standard deviation (SD) of 13%, indicating good repeatability of the method [37]. Geis-Asteggiante et al conducted experiments for evaluation various clean-up sorbents and their combinations for extracts purification in multiresidue method for monitoring 127 veterinary drug residues in bovine meat using UHPLC-MS/MS [38]. Z-Sep and Z-Sep Plus allowed effective getting rid of co-extractives, but in the light of obtained veterinary drugs recoveries were inappropriate.…”

Section: Application Of Alternative Sorbents In the D-spementioning

confidence: 99%

A review of recent developments and trends in the QuEChERS sample preparation approach

2015

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Abstract:A comprehensive review is presented on the recent developments and trends in the QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation approach. This technique involves liquidliquid partitioning using acetonitrile and purifying the extract using dispersive solid-phase extraction (d-SPE). Originally, the QuEChERS was introduced for pesticides residues analysis in high moisture fruits and vegetables, but more recently it is gaining significant popularity in the analysis of broad spectrum of analytes in huge variety of samples. The wide range of the technique applications is possible due to introducing various modifications based on the use of different extraction solvent and salt formulation and buffer additions for salting-out partitioning step and the application of various d-SPE sorbents for clean-up step. Therefore, the QuEChERS approach is useful for analysis of, among others pesticides, veterinary drugs and other pharmaceuticals, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), dyes, acrylamide, synthetic musks and UV filters, bisphenols, polybrominated diphenyl ethers and other flame retardants, endocrine disruptors, and other chemical compounds. Thanks to the QuEChERS approach, high-throughput multiresidue methods operate in a routine contaminant control of food products, feedstuff, and environmental samples.

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Ruggedness testing and validation of a practical analytical method for >100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography–tandem mass spectrometry

Cited by 110 publications

References 29 publications

Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS

Comprehensive analysis of toxics (pesticides, veterinary drugs and mycotoxins) in food by UHPLC-MS

Development and Validation of a Multi-class UHPLC-MS/MS Method for Determination of Antibiotic Residues in Dairy Products

A review of recent developments and trends in the QuEChERS sample preparation approach

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