Rumex hastatus derived silver nanoparticles development and their potential applications as hepatic-protection agent along with antimicrobial activity

Gül, Hina; Khan, F.A.; Afzal, Umara; Batool, Salma; Saddick, Salina; Awais, Muhammad; Irum, Samra; Malik, M.Y.; Khan, Mohammad Iqbal; Alhazmi, Alaa; Khan, Sami Ullah

doi:10.1016/j.jksus.2021.101587

Cited by 13 publications

(5 citation statements)

References 32 publications

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“…Aspartate aminotransferase (AST), also known as serum glutamic‐oxaloacetic transaminase (SGOT), is an enzyme predominantly found in the liver, heart, skeletal muscles, and other organs. It plays a vital role in various physiological processes, and elevated AST levels can indicate liver cell damage, inflammation or liver cancer [42] . The findings of our study indicate that in the G1 group of mice, which were solely treated with the EAC cell line, there was a significant increase in AST levels, reaching 648±7.21 unit/L (Figure 7).…”

Section: Discussionmentioning

confidence: 62%

“…It plays a vital role in various physiological processes, and elevated AST levels can indicate liver cell damage, inflammation or liver cancer. [42] The findings of our study indicate that in the G1 group of mice, which were solely treated with the EAC cell line, there was a significant increase in AST levels, reaching 648 � 7.21 unit/L (Figure 7). This elevated AST level suggests the presence of metastasis, indicating that cancer has spread to other organs, particularly the liver, as AST is commonly associated with liver function.…”

Section: Anticancer Activitymentioning

confidence: 59%

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Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes

Hosen,

Rahman,

Rahman

et al. 2024

Chemistry & Biodiversity

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Both diabetes and cancer pose significant threats to public health. To overcome these challenges, nanobiotechnology offers innovative solutions for the treatment of these diseases. However, the synthesis of nanoparticles can be complex, costly and environmentally toxic. Therefore, in this study, we successfully synthesized Camellia sinensis silver nanoparticles (CS‐AgNPs) biologically from methanolic leaf extract of C. sinensis and as confirmed by the visual appearance which exhibited strong absorption at 456 nm in UV‐visible spectroscopy. The fourier transform infrared spectroscopy (FTIR) analysis revealed that phytochemicals of C. sinensis were coated with AgNPs. Scanning electron microscopy (SEM) analysis showed the spherical shape of CS‐AgNPs, with a size of 15.954 nm, while X‐ray diffraction spectrometry (XRD) analysis detected a size of 20.32 nm. Thermogravimetric analysis (TGA) indicated the thermal stability of CS‐AgNPs. The synthesized CS‐AgNPs significantly inhibited the ehrlich ascites carcinoma (EAC) cell growth with 53.42±1.101 %. The EAC cell line induced mice exhibited increased level of the serum aspartate aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), however this elevated serum parameter significantly reduced and controlled by the treatment with CS‐AgNPs. Moreover, in a streptozotocin‐induced diabetic mice model, CS‐AgNPs greatly reduced blood glucose, total cholesterol, triglyceride, low‐density lipoprotein (LDL) and creatinine levels. These findings highlight that the synthesized CS‐AgNPs have significant anticancer and antidiabetic activities that could be used as promising particles for the treatment of these major diseases. However, pre‐clinical and clinical trial should be addressed before use this particles as therapeutics agents.

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Section: Discussionmentioning

confidence: 62%

Section: Anticancer Activitymentioning

confidence: 59%

Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes

Hosen,

Rahman,

Rahman

et al. 2024

Chemistry & Biodiversity

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“…Low doses (25 mg/kg body weight) of AgNPs were found to be effective in the revival of all the liver parameters without causing toxic effects [ 66 ]. Similarly, AgNPs were effective against CCl 4 -induced toxicity in albino rats even at low concentrations and also showed a cytotoxic effect on the HepG2 cell line with great antioxidant and antimicrobial potential [ 67 ]. In addition, AgNPs also showed hepatoprotective effects by increasing total protein levels as compared to CCl 4 -treated rats.…”

Section: Nanoparticles and Their Interaction With Liver And Kidney Cellsmentioning

confidence: 99%

Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives

et al. 2022

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Liver and kidney diseases are the most frequently encountered problems around the globe. Damage to the liver and kidney may occur as a result of exposure to various drugs, chemicals, toxins, and pathogens, leading to severe disease conditions such as cirrhosis, fibrosis, hepatitis, acute kidney injury, and liver and renal failure. In this regard, the use of nanoparticles (NPs) such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc oxide nanoparticles (ZnONPs) has emerged as a rapidly developing field of study in terms of safe delivery of various medications to target organs with minimal side effects. Due to their physical characteristics, NPs have inherent pharmacological effects, and an accidental buildup can have a significant impact on the structure and function of the liver and kidney. By suppressing the expression of the proinflammatory cytokines iNOS and COX-2, NPs are known to possess anti-inflammatory effects. Additionally, NPs have demonstrated their ability to operate as an antioxidant, squelching the generation of ROS caused by substances that cause oxidative stress. Finally, because of their pro-oxidant properties, they are also known to increase the level of ROS, which causes malignant liver and kidney cells to undergo apoptosis. As a result, NPs can be regarded as a double-edged sword whose inherent therapeutic benefits can be refined as we work to comprehend them in terms of their toxicity.

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“…This plant is a member of the Polygonaceae family and is found in the hilly region of Pakistan. Earlier studies reported that the Rumex dentatus exhibits excellent antibacterial activity [27].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy of Rumex dentatus leaf extract-enriched zinc oxide and iron doped zinc nanoparticles: a comparative study

Shakeel,

Nur,

Sultana

et al. 2024

Nanotechnology

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In the current investigation, Zinc oxide (ZnO) nanoparticles and Fe-doped ZnO nanoparticles were sustainably synthesized utilizing an extract derived from the Rumex dentatus plant through a green synthesis approach. The Scanning electron microscope (SEM), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDX), Ultra-violet visible spectroscopy (UV-vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), and Thermogravimetric analysis( TGA) techniques were used to examine the compositional, morphological, optical, and thermal properties of both samples. The doping of iron into ZnO NPs has significantly influenced their properties. The analysis firmly established that both ZnO NPs and Fe-doped ZnO NPs have hexagonal wurtzite structures and spherical shapes by XRD and SEM. The EDX analysis suggests that iron atoms have been successfully integrated into the ZnO lattice. The change in color observed during the reaction indicated the formation of nanoparticles. The UV-vis peaks at 364 nm and 314 nm confirmed the presence of ZnO NPs and Fe-doped ZnO NPs, respectively. The band gap of ZnO NPs by Fe dopant displayed a narrowing effect. This indicates that adding iron ions to ZnO NPs offers a control band gap. The thermal study TGA revealed that Fe-doped ZnO NPs remain stable when heated up to 600 °C. The antibacterial efficacy of ZnO NPs and Fe-doped ZnO NPs was evaluated against several bacterial strains. The evaluation is based on the zone of inhibition (ZOI). Both samples exhibited excellent antibacterial properties as compared to conventional pharmaceutical agents. These results suggest that synthesizing nanoparticles through plant-based methods is a promising approach to creating versatile and environmentally friendly biomedical products.

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Rumex hastatus derived silver nanoparticles development and their potential applications as hepatic-protection agent along with antimicrobial activity

Cited by 13 publications

References 32 publications

Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes

Synthesis of Silver Nanoparticles Using Camellia sinensis Leaf Extract: Promising Particles for the Treatment of Cancer and Diabetes

Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives

Antibacterial efficacy of Rumex dentatus leaf extract-enriched zinc oxide and iron doped zinc nanoparticles: a comparative study

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