Rupestonic acids B–G, NO inhibitory sesquiterpenoids from Artemisia rupestris

Zhang, Chen; Wang, Shu; Zeng, Ke‐Wu; F, Cui; Jin, Hongwei; Guo, Xiaoyu; Jiang, Yong; Tu, Peng‐Fei

doi:10.1016/j.bmcl.2014.07.008

Cited by 18 publications

(2 citation statements)

References 24 publications

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“…Rupestonic acid, extracted from Artemisiae Rupestridis Herba, has been demonstrated to have antioxidant activities 19 . Recently, a derivative YZH-106 of rupestonic acid was found inhibit the replication of IAV by up-regulating HO-1 expression 20 .…”

Section: Resultsmentioning

confidence: 99%

Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

Yin

Wang

et al. 2017

Acta Pharmaceutica Sinica B

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As a leading cause of respiratory disease, influenza A virus (IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet (CYZH) is a famous traditional Chinese medicine (TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB), which subsequently upregulated heme oxygenase-1 (HO-1) expression. Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions, CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway.

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Section: Resultsmentioning

confidence: 99%

Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

Yin

Wang

et al. 2017

Acta Pharmaceutica Sinica B

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“…Guaianes are sesquiterpenoids bearing a bicyclo[5.3.0]-decane skeleton with enormously structural diversities, including nor-guaianes 1 , guaiane alkaloids 2 , 3 , guaiane dimers 4 , 5 , etc . They possessed a variety of intriguingly biological activities, such as antioxidant 2 , antimalarial 6 , 7 , antinociceptive 7 , anti-emetic 8 , antitumor 9 – 11 , anti-inflammatory 12 , 13 , and antibacteria 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421

Niu

Xie

Xia

et al. 2018

Sci Rep

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Nine new guaianes (graphostromanes A–I, 1–9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10–13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher’s method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC50 value of 14.2 μM, which was even stronger than that of aminoguanidine, a positive control with an IC50 value of 23.4 μM.

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Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities

et al. 2021

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Rupestonic acids B–G, NO inhibitory sesquiterpenoids from Artemisia rupestris

Cited by 18 publications

References 24 publications

Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1

New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421

Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities

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