Russian Experimental Fiction

Clowes, Edith W.

doi:10.1515/9781400863532

Cited by 11 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3] However, synthetic materials have shown disheartening failures in small-diameter applications such as coronary artery bypass grafting because of rapid occlusion caused by thrombosis and intimal hyperplasia. [3][4][5][6] Numerous strategies have been investigated to improve the performance of small-diamater vascular grafts, but to date, clinical success has not been achieved.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Producing Polyurethanes

2005

View full text Add to dashboard Cite

Thrombus formation and eventual intimal hyperplasia are the leading causes of small-diameter synthetic vascular graft failure. To combat these issues, we have incorporated a diazeniumdiolate-modified nitric oxide (NO)-producing peptide into a polyurethane to improve the thromboresistance of this biocompatible polymer. NO production by polyurethane films occurred for approximately 2 months under physiological conditions, and mechanical properties of the material were suitable for vascular graft applications. Platelet adhesion to NO-releasing polyurethane was dramatically decreased compared to control polyurethane. Furthermore, endothelial cell growth was stimulated in the presence of the NO-releasing polyurethane, while smooth muscle cell growth was greatly inhibited. The ability of this bioactive material to inhibit platelet adhesion and smooth muscle cell proliferation while encouraging endothelialization suggests that this NO-generating polyurethane may be suitable as a candidate material for small-diameter vascular grafts.

show abstract

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Producing Polyurethanes

2005

View full text Add to dashboard Cite

show abstract

“…ePTFE (expanded polytetra uoroethylene), Dacron (polyethylene teraphthalate) and microporous polyurethanes have been successfully used as large diameter (>6 mm) vascular substitutes [1,5,6]. However, when used in small diameter applications, they have not been satisfactory due to thrombosis and intimal hyperplasia [2,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Endothelialization of synthetic grafts is a possible strategy to improve graft patency [8,17]. However, since endothelial cells often detach on exposure physiological shear stress, the graft patency is dependent on the attachment and retention of endothelial cells on the surface.…”

Section: Introductionmentioning

confidence: 99%

Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization

Jun¹,

West²

2004

Journal of Biomaterials Science, Polymer Edition

View full text Add to dashboard Cite

Polyurethanes have been investigated for use as vascular grafts due to their excellent mechanical properties and relatively good biocompatibility. However, poor retention of endothelial cells and thrombogenicity in vivo remain problematic for vascular graft applications. The peptide YIGSR has been shown to increase endothelial cell adhesion but not attachment of platelets, suggesting its possible utility for vascular graft applications. In this study, a bioactive polyurethaneurea has been synthesized by incorporating GGGYIGSRGGGK peptide sequences into the polymer backbone. Successful incorporation of the peptides was confirmed by NMR, contact angle measurement and ESCA. Uniform distribution of peptides on the surface was observed using a fluorescent probe capable of reacting with tyrosine residues on the peptides. Hard segment domains were visualized using tapping mode AFM. Endothelial cell adhesion, spreading, proliferation, migration and extra-cellular matrix production were improved on bioactive polyurethaneurea compared to control polyurethaneurea. Competitive inhibition of endothelial cell attachment and spreading by soluble YIGSR peptides indicated that cell adhesion and spreading were specifically mediated by YIGSR-sensitive cell adhesion receptor, not just by changed surface properties. There was no significant difference in the number of adherent platelets. Therefore, this bioactive polyurethanurea may improve vascular graft endothelialization without increasing thrombogenicity.

show abstract

“…Synthetic materials such as microporous polyurethanes, expanded poly(tetrafluoroethylene) (ePTFE) and Dacron [poly(ethylene teraphthalate)] have been successfully used as large-diameter ([6 mm) vascular substitutes [2][3][4]. Currently, these materials for small-diameter applications such as coronary artery bypass grafting have been largely unsuccessful due to rapid occlusion caused by thrombosis and intimal hyperplasia [4][5][6][7]. To overcome those problems, numerous strategies have been investigated to improve the performance of small-diamater vascular grafts, including endothelization on these biomaterials surfaces [8], tissue engineering fabrication [9], and chemical modification [10,11].…”

Section: Introductionmentioning

confidence: 99%

A novel strategy to graft RGD peptide on biomaterials surfaces for endothelization of small-diamater vascular grafts and tissue engineering blood vessel

Ding

et al. 2008

J Mater Sci: Mater Med

View full text Add to dashboard Cite

To improve the performance of small-diamater vascular grafts, endothelization of biomaterials surfaces and tissue engineering are more promising strategies to fabricate small-diamater vascular grafts. In this study, a Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide was grafted on the surfaces of poly(carbonate urethane)s (PCUs), with photoactive 4-benzoylbenzoic acid (BBA) by UV irradiation. The photoactive peptides (BBM-GRGDSP) were synthesized with classical active ester of peptide synthesis. The modified surfaces of PCU with the photoactive RGD peptides were characterized by water contact angle measurement and X-ray Photoelectron Spectroscopy (XPS), which results suggested that the peptides were successfully grafted on the PCU surfaces. The effect of these modified surfaces on endothelial cells (ECs) adhesion and proliferation was examined over 72 h. PCU surfaces coupled with the synthetic photoactive RGD peptides, as characterized with phase contrast microscope and the metabolic activity (MTT) assay enhanced ECs proliferation and spreading with increasing concentration of RGD peptides grafted on their surfaces. Increased retention of ECs was also observed on the polymers surfaces under flow shear stress conditions. The results demonstrated that GRGDSP peptides grafted on the surfaces of polymers with photoactive 4-benzoylbenzoic acids could be an efficient method of fabrication for artificial small-diamater blood vessels. The modified polymer is expected to be used for small-diamater vascular grafts and functional tissue engineered blood vessels to improve ECs adhesion and retention on the polymer surfaces under flow shear stress conditions.

show abstract

Russian Experimental Fiction

Cited by 11 publications

References 0 publications

Nitric Oxide-Producing Polyurethanes

Nitric Oxide-Producing Polyurethanes

Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization

A novel strategy to graft RGD peptide on biomaterials surfaces for endothelization of small-diamater vascular grafts and tissue engineering blood vessel

Contact Info

Product

Resources

About