Rutin ameliorates oxidative stress and preserves hepatic and renal functions following exposure to cadmium and ethanol

Njoku, Rex-Clovis C; Lawrence, Chiamaka J.; Charles, Iniobong A.; Ikewuchi, Jude Chigozie

doi:10.1080/13880209.2017.1387575

Cited by 39 publications

(19 citation statements)

References 39 publications

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“…Another finding parallel to this damage is a decrease in the body weight of animals and a significant increase in liver weight and liver weight/body weight ratio. Comparing current studies with previous studies on cadmium exposure; oxidative stress parameters (Abarikwu, Njoku, Lawrence, Charles, & Ikewuchi, ; Dkhil et al, ; Eşrefoglu et al, ; Jurczuk et al, ; Karaca and Eraslan, ; Koyu et al, ; Layachi and Kechrid, ; Xu et al, ; Zhang et al, ), some biochemical parameters (Abarikwu et al, ; Layachi & Kechrid, ; Pari & Murugavel, ; Pari & Shagirtha, ; Zhang et al, ), liver histopathology (Andjelkovic et al, ; Koyu et al, ; Olisekodiaka, Igbeneghu, Onuegbu, Oduru, & Lawal, ; Xu et al, ) and, in terms of body weight and liver weight (Layachi & Kechrid, ) have similarities.…”

Section: Discussionsupporting

confidence: 62%

The effect of diosmin against liver damage caused by cadmium in rats

Ağır

Eraslan

2019

J Food Biochem

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A total of 40, male Wistar Albino, 2–3‐months‐old rats were used and divided into four groups. Control group received the vehicle alone, diosmin group received 100 mg/kg.bw diosmin, the cadmium group received 200 ppm cadmium, cadmium plus diosmin group received 200 ppm cadmium, and 100 mg/kg.bw diosmin for 30 days. Some biochemical parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase) and oxidative stress parameters (malondialdehyde [MDA], nitric oxide [NO], superoxide dismutase [SOD], catalase [CAT], gluthatione peroxidase [GSH‐Px], and glutathione [GSH]) were analyzed in the samples. Histo‐pathological findings were evaluated in the liver. The body weights and liver weights of the animals were measured. The MDA and NO levels and biochemical enzyme activities examined were increased, whereas SOD, CAT, and GSH‐Px activities and GSH levels decreased in cadmium‐exposed group. There were also negative changes in body weight, liver weight, and liver tissue histo‐phathology. Positive improvements were observed in all these parameters evaluated of the group co‐administered cadmium and diosmin. Practical applications Cadmium is one of the common environmental pollutants. Diosmin is a type of flavonoid found mainly in citrus fruits. It can also be produced from hesperidine. This compound is used for medical purposes and also has strong antioxidant properties. One of the toxic effects mechanisms of cadmium is oxidative stress and causes liver damage with different pathways. This compound can be used as a supporting agent in addition to the main treatment options against liver damage in case of exposure to possible cadmium. This flavonoid can also be taken with food for prophylactic purposes.

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Section: Discussionsupporting

confidence: 62%

The effect of diosmin against liver damage caused by cadmium in rats

Ağır

Eraslan

2019

J Food Biochem

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“…It should be emphasized that although at the low-level exposure to Cd oxidative stress was noted after 10 months, unfavorable changes of some parameters of the oxidative/antioxidative barrier were recorded already after 3 months of the intoxication. Taking into account the fact that morphological changes in hepatocytes, including oxidative damage to the cellular and intracellular membranes, result in disorders in the proper function of the liver [23,24,25,41,44,45,46]; based on the findings of the present study it can be concluded that low chronic exposure to Cd may also impair the function of this organ. The pathological changes in the morphological picture of the liver described by us are similar to these observed by other authors due to repeated intoxication with Cd [23,24,40,41,44,45].…”

Section: Discussionmentioning

confidence: 58%

Extract from Aronia melanocarpa L. Berries Prevents Cadmium-Induced Oxidative Stress in the Liver: A Study in A Rat Model of Low-Level and Moderate Lifetime Human Exposure to this Toxic Metal

et al. 2018

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The study investigated, in a rat model of low-level and moderate environmental exposure to cadmium (Cd; 1 or 5 mg Cd/kg diet, respectively, for 3 to 24 months), whether the co-administration of 0.1% extract from Aronia melanocarpa L. berries (AE) may protect against oxidative stress in the liver and in this way mediate this organ status. The intoxication with Cd, dose- and duration-dependently, weakened the enzymatic antioxidative barrier, decreased the concentrations of reduced glutathione and total thiol groups, and increased the concentrations of oxidized glutathione, hydrogen peroxide, xanthine oxidase, and myeloperoxidase in this organ. These resulted in a decrease in the total antioxidative status, increase in the total oxidative status and development of oxidative stress (increased oxidative stress index and malondialdehyde concentration) and histopathological changes in the liver. The administration of AE at both levels of Cd treatment significantly improved the enzymatic and nonenzymatic antioxidative barrier, decreased pro-oxidant concentration, and protected from the development of oxidative stress in the liver and changes in its morphology, as well as normalized the serum activities of liver enzymes markers. In conclusion, consumption of aronia products may prevent Cd-induced destroying the oxidative/antioxidative balance and development of oxidative stress in the liver protecting against this organ damage.

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“…Increased body weights of rats in all groups, during the 60 days exposure to TO diets, indicates the absence of general toxicity (Abarikwu, Olufemi, et al., ). The nonsignificant decrease in relative and absolute testes weights of rats consuming 10% and 15% TO‐supplemented diets could be due to mild aberrant morphology (Abarikwu, Njoku, Lawrence, Charles, & Ikewuchi, ) and also indicates that boiled seeds of TO are toxic to the interstitial tissue and seminiferous tubules (Adisa et al., ; Kassem et al., ). Increased abnormal sperm morphology and reduced epididymal sperm number were also observed in rats administered TO diets.…”

Section: Discussionmentioning

confidence: 99%

“…The elevation and/or reduction in antioxidant defence systems accompanied by a concomitant increase in MDA concentration highlights the induction of oxidative stress (Abarikwu, Njoku, et al., ; Imamoğlu, Bülbül, Kaklikkaya, & Sarihan, ). More so, the increase in the activities or levels of antioxidant defence in experimental models is seen as an adaptive response to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

2018

Self Cite

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The growing patronage on herbal remedies and formulations from natural products in most developing countries has warranted research into certain health challenges including their antifertility effects. This study assessed the effects of boiled Telfairia occidentalis (TO) seed-supplemented diets on the level of testosterone and semen quality in Wistar rats. Boiled TO seed diets at 10%, 15% and 30% were given to rats for 60 days. Our study showed that sperm quality was impaired as evidenced by the decreased number of motile spermatozoa, epididymal sperm numbers, percentage live/dead ratio and increased numbers of abnormal spermatozoa comparable to control values (p < .05). Feeding of rats with 10% and 15% TO seed-supplemented diets increased testosterone levels nonsignificantly, while in the 30% TO seed diet animals, the level of serum testosterone was found to decrease significantly compared to control values. Furthermore, TO diet caused a nonsignificant increase in the activity of superoxide dismutase and the concentrations of reduced glutathione and malondialdehyde except for the significant increase in malondialdehyde level in the testes of the 10% TO diet group. A nonsignificant decrease in myeloperoxidase activity was also observed in the 10% and 15% but not 30% TO diet group. Histological damages characterised by severe loss of germ cells were more pronounced in the 10% TO diet group. Fourier transform infrared spectroscopy analysis of boiled TO seeds revealed the presence of esters, alkenes, hydroxyl and alcohol functional groups. Thus, boiled TO seed-supplemented diet evoked antifertility effects in rats, and the effects on the toxicity end points investigated were not dose-dependent.

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Rutin ameliorates oxidative stress and preserves hepatic and renal functions following exposure to cadmium and ethanol

Cited by 39 publications

References 39 publications

The effect of diosmin against liver damage caused by cadmium in rats

The effect of diosmin against liver damage caused by cadmium in rats

Extract from Aronia melanocarpa L. Berries Prevents Cadmium-Induced Oxidative Stress in the Liver: A Study in A Rat Model of Low-Level and Moderate Lifetime Human Exposure to this Toxic Metal

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

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