Rutin as A Novel c-Met Inhibitory Lead for The Control of Triple Negative Breast Malignancies

Elsayed, Heba E.; Ebrahim, Hassan Y.; Mohyeldin, Mohamed M.; Siddique, Abu Bakar; Kamal, Ahmed A. M.; Haggag, Eman; Sayed, Khalid A. El

doi:10.1080/01635581.2017.1367936

Cited by 51 publications

(30 citation statements)

References 31 publications

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“…Another study has shown that grape stem extract rich in flavonols, particularly rutin, inhibited the growth of MCF-7 cancer cell line [43]. Elsayed et al reported that rutin inhibited c-Met kinase activity in the triple negative breast cancer cell line, significantly reducing the growth of MDA-MB-231/GFP orthotopic xenograft in nude mouse model [44]. Rutin is a common dietary flavonoid found in fruits, vegetables, and plant-derived beverages [45].…”

Section: Discussionmentioning

confidence: 99%

Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals

et al. 2019

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Estrogen receptor antagonists are effective in breast cancer treatment. However, the side effects of these treatments have led to a rise in searching for alternative therapies. The present study evaluated the estrogenic, antiestrogenic, and antiproliferative activities of Euphorbia bicolor (Euphorbiaceae), a plant native to south-central USA. Estrogenic and antiestrogenic activities of latex extract and its phytochemicals were evaluated with a steroid-regulated yeast system expressing the human estrogen receptor α and antiproliferative properties were assessed in the ER-positive MCF-7 and T47-D and triple-negative MDA-MB-231 and MDA-MB-469 breast carcinomas. Genistein and coumestrol identified in the latex extract induced higher estrogenic and antiestrogenic activities compared to diterpenes and flavonoids. The latex extract, resiniferatoxin (RTX) and rutin induced antiproliferative activities in all cell lines in a dose-dependent manner, but not in human normal primary dermal fibroblast cultures. A biphasic effect was observed with MDA-MB-468 breast carcinoma in which the latex extract at low concentrations increased and at high concentrations decreased cell proliferation. Treatments with latex extract in combination with RTX or rutin reduced even more the proliferation of MCF-7 breast carcinoma compared to the individual latex, RTX, and rutin treatments. E. bicolor latex phytochemicals could contribute to developing commercial therapeutic agents for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals

et al. 2019

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“…Rutin was also reported to stimulate apoptosis in human breast cancer cells, whereas reinstating the chemosensitivity of HER2 negative and triple-negative breast cancer cells (27). Elsayed et al reported that rutin prevents the activity c-Met kinase in TNBC cells thus considerably reducing the growth of TNBC MDA-MB-231/GFP orthotopic xenografts in murine models (28). Organometallic compounds centered around transition metals have developed as favorable scaffolds in the quest for antitumor leads (29).…”

Section: Vanadium-rutin Complex Sensitizes Breast Cancer Cellsmentioning

confidence: 99%

Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

Zhu¹,

Wang²,

Liu³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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In pursuit of a novel approach in breast cancer therapy, we explored the ability of vanadium-rutin complex to eradicate cancer by efficiently targeting various apoptotic pathways on human breast cancer cell lines. We provide direct proof of the chemotherapeutic potential of the vanadium-rutin complex by activating p-53 dependent intrinsic apoptosis and modulating the VEGF pathways. The complex was also capable of binding and cleaving CT-DNA at different concentrations. The complex was able to inhibit cell viability at 100 and 150 µM doses in both MCF7 and MDA-MB-231 cells. Furthermore, the complex successfully initiated apoptosis in both cell lines by activating the p53 dependent intrinsic apoptotic pathway. In vitro studies also established that the complex modulated p53, Bax, Bcl2 and VEGF expressions and induced DNA fragmentation in both the cell lines.

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“…Rutin ( Figure 2 F and Figure 3 ) (rutoside, quercetin-3-O-rutinoside and sophorin), a glycoside combining the flavanol, quercetin, and the disaccharide, rutinose, is widely present in citrus fruits [ 178 , 238 ]. Rutin has anti-carcinogenic, anti-inflammatory, and antioxidant properties [ 178 ].…”

Section: Phytochemicals As Anticancer Compounds Effective In the Tmentioning

confidence: 99%

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Varghese

Samuel

Abotaleb

et al. 2018

Cancers

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Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggressive, do not respond to conventional hormonal/human epidermal growth factor receptor 2 (HER2)-targeted interventions due to the lack of the respective receptor targets, have chances of early recurrence, metastasize, tend to be more invasive in nature, and develop drug resistance. The global burden of TNBCs is increasing regardless of the number of cytotoxic drugs being introduced into the market each year as they have only moderate efficacy and/or unforeseen side effects. Therefore, the demand for more efficient therapeutic interventions, with reduced side effects, for the treatment of TNBCs is rising. While some plant metabolites/derivatives actually induce the risk of cancers, many plant-derived active principles have gained attention as efficient anticancer agents against TNBCs, with fewer adverse side effects. Here we discuss the possible oncogenic molecular pathways in TNBCs and how the purified plant-derived natural compounds specifically target and modulate the genes and/or proteins involved in these aberrant pathways to exhibit their anticancer potential. We have linked the anticancer potential of plant-derived natural compounds (luteolin, chalcones, piperine, deguelin, quercetin, rutin, fisetin, curcumin, resveratrol, and others) to their ability to target multiple dysregulated signaling pathways (such as the Wnt/β-catenin, Notch, NF-κB, PI3K/Akt/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and Hedgehog) leading to suppression of cell growth, proliferation, migration, inflammation, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, and activation of apoptosis in TNBCs. Plant-derived compounds in combination with classical chemotherapeutic agents were more efficient in the treatment of TNBCs, possibly with lesser side effects.

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Rutin as A Novel c-Met Inhibitory Lead for The Control of Triple Negative Breast Malignancies

Cited by 51 publications

References 31 publications

Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals

Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals

Vanadium rutin complex sensitizes breast cancer cells via modulation of p53/Bax/Bcl2/VEGF correlated with apoptotic events

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

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