Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB

Kyung, Tae Wook; Lee, Ji Eun; Shin, Hyun Hee; Choi, Hye-Seon

doi:10.3858/emm.2008.40.1.52

Cited by 59 publications

(40 citation statements)

References 26 publications

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“…The mature osteoclasts have a capacity for bone resorption. 12 In the process of osteoclastogenesis, 12 This is in accordance with the opinion of Kyung et al, 13 that osteoclasts are cells responsible for bone resorption process, which is formed from haemopoetic stem cell. The regulation of osteoclastogenesis in inflammation, such as arthritis, proinflammatory cytokines (IL1, IL 6 and TNF-a), and RANKL, can stimulate osteoclasts and bone damage.…”

supporting

confidence: 62%

Stimulation of osteoblast activity by induction of Aloe vera and xenograft combination

Kresnoadi

Rahayu

2011

Dent. J. (Majalah Kedokteran Gigi)

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supporting

confidence: 62%

Stimulation of osteoblast activity by induction of Aloe vera and xenograft combination

Kresnoadi

Rahayu

2011

Dent. J. (Majalah Kedokteran Gigi)

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“…Many anti-inflammatory drugs are known to target to inhibit an activation of this transcription factor. (D'Acuisto et al, 2002;Kyung et al, 2008) However, the effects on activity of transcription factors by KBH-A42 are quite mixed-up in RAW 264.7 cells (Figure 4). The effect of KBH-A42 on transcription factors was determined by measuring the extent of DNA binding of transcription factors.…”

Section: Mechanism Studymentioning

confidence: 99%

Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

et al. 2008

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In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its anti-inflammatory activities. KBH-A42 showed noteworthy anti-inflammatory properties in vitro via suppression of the production of TNF-α, a proinflammatory cytokine, and nitric oxide (NO), a proinflammatory effector molecule, in LPS-stimulated RAW264.7 cells and peritoneal macrophages. It also inhibited TNF-α production in vivo as demonstrated in a LPS-induced mouse endotoxemia model. The levels of TNF-α, IL-1β, IL-6 and iNOS mRNAs determined by RT-PCR propose that the inhibition of these pro-inflammatory mediators by KBH-A42 resulted from inhibiting expression of these genes. However, the EMSA study to see the effect of KBH-A42 on the binding of NF-κB, a transcription factor, to a specific DNA sequence showed that the binding of NF-κB to DNA was not changed regardless of increasing the concentration of KBH-A42 in the presence and absence of LPS stimulation. Interestingly, DNA binding of another transcription factor AP-1 dose-dependently increased by KBH-A42. KBH-A42 differentially regulated the phosphorylation of MAP kinases. While the phosphprylation of ERK1/2 and SAPK/JNK was not affected by KBH-A42, the phosphorylation of p38 decreased by KBH-A42. These results showed that KBH-A42 inhibits production of proinflammatory cytokines in macrophages by decreasing their mRNA levels, and p38 kinase is involved in the KBH-A42-mediated inhibition.

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“…NF-κB plays a very important role in expression of pro-inflammatory mediators such as NO, interleukins and TNF-α. Many anti-inflammatory drugs exert their activities via inhibition of the activation of this transcription factor (D'Acquisto et al, 2002;Kyung et al, 2008). Here, our results demonstrate that Palmatine and columbamine, two major alkaloids constituents in Radix Tinosporae, showed significant inhibitory effects on LPS-stimulated production of NO and TNF-α-induced NF-κB activation in RAW 264.7 macrophages, while columbaminyl glucoside showed no inhibitory activity.…”

Section: Discussionmentioning

confidence: 54%

Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.

Liu

Shi

et al. 2010

Arch. Pharm. Res.

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Radix Tinosporae is a herb widely used in traditional Chinese medicine for the treatment of various inflammatory diseases. In the present study, its anti-inflammatory and antinociceptive activities were investigated. The ethanol extract of Radix Tinosporae exhibited significant inhibitory effects on xylene-induced ear edema and acetic acid-induced writhing in mice. Using bioassay-guided fractionation, the n-butanol fraction was determined as the active fraction. Further purification of the most active n-butanol fraction led to the isolation of three compounds, palmatine, columbamine and columbinyl glucoside. All three compounds showed inhibitory activities on xylene-induced ear edema, but only palmatine and columbamine exhibited significant inhibitory effects on acetic acid-induced writhing. In addition, palmatine and columbamine markedly inhibited in vitro production of nitric oxide and nuclear factor-kappaB activation in RAW264.7 macrophage cells in response to lipopolysaccharide or tumor necrosis factor alpha stimulation. These results provide justification for the utilization of Radix Tinosporae in Chinese folk medicine for the treatment of inflammatory diseases.

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Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB

Cited by 59 publications

References 26 publications

Stimulation of osteoblast activity by induction of Aloe vera and xenograft combination

Stimulation of osteoblast activity by induction of Aloe vera and xenograft combination

Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.

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